Biomedical subjects

N M Harnett

Publications and source records attributed to N M Harnett.

3 recordsLinked to original sources

PubMed1977

Inhibition of the biologic effects of endotoxin on neutrophils by polymyxin B sulfate.

Polymyxin B sulfate diminished the endotoxin-mediated release of human blood neutrophil lysosomal enzymes. Similarly, this antibiotic reduced the endotoxin-induced increase in the neutrophil hexose monophosphate pathway activity as measured by the release of 14CO2 from [l-14C]glucose. Although these effects were seen with therapeutically attainable levels of polymyxin B sulfate, they could not be demonstrated when the cell-endotoxin interaction preceded treatment with polymyxin B sulfate.

Endotoxins↗

PubMed1977

Protective effect of polymyxin B sulfate in experimental meningococcal infection in mice.

The mouse model of intraperitoneal meningococcal sepsis was used to evaluate the antiendotoxic activity of polymyxin B sulfate independent of its antibiotic effects. Administered either before or after the infective challenge therapeutic doses of polymyxin B sulfate produced small but significant increases in survival over unprotected animals. These results also suggest that endotoxin contributes to the outcome in this variety of Gram-negative infection.

Animals↗

PubMed1976

Metronidazole and acne.

The strong activity of metroindazole against obligate anaerobes suggested that the organism Proprionobacterium acnes and the disease acne vulgaris might respond to treatment with this drug. Thirty-three clinical isolated of P. acnes were tested and found to be highly resistant to metronidazole. Prospects for its successful use in acne are remote.

Drug Resistance, Microbial↗