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Biomedical subjects

N M Hunkin

Publications and source records attributed to N M Hunkin.

At least 19 recordsLinked to original sources
PubMed2004

Visual paired comparison performance is impaired in a patient with selective hippocampal lesions and relatively intact item recognition.

In this study, we have examined visual recognition memory in a patient, YR, with discrete hippocampal damage who has shown normal or nearly normal item recognition over a large number of tests. We directly compared her performance as measured using a visual paired comparison task (VPC) with her performance on delayed matching to sample (DMS) tasks. We also investigated the effect of retention interval between familiarisation and test. YR shows good visual recognition with the DMS task up to 10 s after the familiarisation period, but only shows recognition with the VPC task for the shortest retention interval (0 s). Our results are consistent with the view that hippocampal damage disrupts recollection and recall, but not item familiarity memory.

Brain Damage, Chronic↗
PubMed2002

Relative sparing of item recognition memory in a patient with adult-onset damage limited to the hippocampus.

There is disagreement about whether selective hippocampal lesions in humans cause clear item recognition as well as recall deficits. Whereas Reed and Squire (Behav Neurosci 1997;111:667-775) found that patients with adult-onset relatively selective hippocampal lesions showed clear item recognition deficits, Vargha-Khadem et al. (Science 1997;277: 376-380, Soc Neurosci Abstr 1998;24:1523) found that 3 patients who suffered selective hippocampal damage in early childhood showed clear recall deficits, but had relatively normal item recognition. Manns and Squire (Hippocampus 1999;9:495-499) argued, however, that item recognition may have been spared in these patients because the early onset of their pathology allowed compensatory mechanisms to develop. Therefore, to determine whether early lesion onset is critical for the relative sparing of item recognition and to determine whether its occurrence is influenced by task factors, we extensively examined item recognition in patient Y.R., who has pathology of adult-onset restricted to the hippocampus. Like the developmental cases, she showed clear free recall deficits on 34 tests, but her item recognition on 43 tests was relatively spared, and markedly less disrupted than her recall. Her item recognition performance relative to that of her controls was not significantly influenced by whether tests tapped visual or verbal materials, had a yes/no or forced-choice format, contained few or many items, had one or several foils per target item, used short or very long delays, or were difficult or easy for normal subjects. Interestingly, YR's bilateral hippocampal destruction was greater than at least 2 of the 3 patients of Manns and Squire (Hippocampus 1999;9:495-499). The possible reasons why item recognition differs across patients with relatively selective hippocampal damage of adult-onset and how the reasons that are truly critical can be best identified are discussed.

Age of Onset↗
PubMed2002

Temporal order memory in patients with Korsakoff's syndrome and medial temporal amnesia.

Two groups of patients with global amnesia resulting either from Korsakoff's syndrome (KS) or from medial temporal lobe (MTL) damage were compared with groups of matched healthy control subjects on a list discrimination paradigm. Item recognition memory was matched across the amnesic and control groups in order to determine whether KS, but not MTL amnesics are disproportionately impaired on list discrimination as predicted by Parkin's [Functional significance of etiological factors in human amnesia. In: Squire LR, Butters N, editors. Neuropsychology of memory, 2nd ed. New York: The Guilford Press, 1992] hypothesis. However, both patient groups were impaired disproportionately on the temporal order memory task, which is inconsistent with Parkin's hypothesis. It remains possible that the KS patients are more disproportionately impaired than those with MTL damage because both patient groups performed at floor on the list discrimination task. The results are consistent with theories that postulate a critical role for the hippocampus in the kind of associative memory which underlies memory for temporal order, but not in recognition of single items or arbitrary associations between items of similar kinds.

Adolescent↗
PubMed2001

Predicting spontaneous recovery of memory.

Long after a new language has been learned and forgotten, relearning a few words seems to trigger the recall of other words. Neural-network models indicate that this form of spontaneous recovery may result from the storage of distributed representations, which are thought to mediate human memory. Here we use a psychomotor learning task to show that a corresponding effect of spontaneous memory recovery occurs in human subjects.

Humans↗
PubMed2001

When is now? Perception of simultaneity.

We address the following question: Is there a difference (D) between the amount of time for auditory and visual stimuli to be perceived? On each of 1000 trials, observers were presented with a light-sound pair, separated by a stimulus onset asynchrony (SOA) between -250 ms (sound first) and +250 ms. Observers indicated if the light-sound pair came on simultaneously by pressing one of two (yes or no) keys. The SOA most likely to yield affirmative responses was defined as the point of subjective simultaneity (PSS). PSS values were between -21 ms (i.e. sound 21 ms before light) and +150 ms. Evidence is presented that each PSS is observer specific. In a second experiment, each observer was tested using two observer-stimulus distances. The resultant PSS values are highly correlated (r = 0.954, p = 0.003), suggesting that each observer's PSS is stable. PSS values were significantly affected by observer-stimulus distance, suggesting that observers do not take account of changes in distance on the resultant difference in arrival times of light and sound. The difference RTd in simple reaction time to single visual and auditory stimuli was also estimated; no evidence that RTd is observer specific or stable was found. The implications of these findings for the perception of multisensory stimuli are discussed.

Acoustic Stimulation↗
PubMed2001

British memory research: a journey through the 20th century.

A century of research in memory has generated a wealth of knowledge encompassing theoretical developments within a number of distinct domains of memory. The aim of this article is to explore the progress made in memory research during the 20th century, to indicate critical influences on the direction of research, and to illustrate the important contribution made by British researchers. This article is confined to human memory research, and reviews research findings from the various psychological disciplines studied over the past 100 years.

History, 20th Century↗
PubMed2000

Does frontal lobe activation during retrieval reflect complexity of retrieved information?

Neuroimaging studies of memory have consistently shown that episodic retrieval is associated with right frontal activation, whereas semantic retrieval is associated with left frontal activation. Various hypotheses have been proposed to account for this lateralization in terms of underlying psychological processes. Alternatively, this lateralization may reflect the complexity of information retrieved: retrieval of complex, contextual information accompanying episodic retrieval invokes right-lateralized processes preferentially. We tested this hypothesis by manipulating the type and complexity of information retrieved. Initial increase in complexity of both episodic and semantic information was associated with right inferior frontal activation; further increase in complexity was associated with left dorsolateral activation. We conclude that frontal activation during retrieval is a non-linear function of the complexity of retrieved information.

Adult↗
PubMed2000

Factor analysis of three standardized tests of memory in a clinical population.

OBJECTIVES: The aim of this study was to determine the factor structure of three standardized memory tests: Wechsler Memory Scale-Revised (WMS-R), Warrington Recognition Memory Test (WRMT), Doors and People Test (D&P). We investigated whether these different standardized tests of memory are consistent in their evaluation of memory function, and the extent to which these tests discriminate between different memory functions (e.g. recall/recognition and verbal/non-verbal memory). DESIGN: Fifty patients with selective memory impairment were tested on the WMS-R, WRMT and D&P. METHODS: Age-scaled scores from selective measures of these tests (WMS-R-verbal, WMS-R-visual, WMS-R-delay, WRMT-words, WRMT-faces, D&P-people, D&P-doors, D&P-shapes, D&P-names) were used as input to a factor analysis. RESULTS: Maximum likelihood factor analysis yielded a three-factor solution consistent with a theoretically motivated fractionation of memory function into recall and recognition components. Recognition performance, but not recall performance, showed dissociation into visual and verbal components. CONCLUSIONS: The WMS-R, WRMT and D&P are highly consistent in their assessment of memory function. The results of the factor analysis are consistent with a theoretically motivated fractionation of recall and recognition memory. They are also partially consistent with a dissociation between visual and verbal memory function.

Adolescent↗
PubMed1998

Are the benefits of errorless learning dependent on implicit memory?

The effectiveness of errorless and errorful learning methods was compared in two experiments in which a group of memory-impaired individuals learned lists of single words. In both experiments, error prevention during learning resulted in higher levels of cued recall performance than trial-and-error learning. Experiment 1 showed that the beneficial effects of the errorless learning method extended over a delay of up to 48 hr and were also observed in free recall. The hypothesis that the benefits of errorless learning rely upon implicit memory was tested in Experiment 2. No evidence was found to support the hypothesis. Implicit memory was observed following both errorless and errorful learning, but there was no indication that enhanced performance in the errorless condition could be accounted for by implicit memory. There was no correlation between performance on a direct test (cued recall) and performance on an indirect test (fragment completion) for the same materials. Furthermore, the extent of priming was no greater for recalled items than non-recalled items in the cued recall test. It is proposed that the benefits of errorless learning in this paradigm stem from the effects of error prevention on residual explicit memory.

Adult↗
PubMed1997

Errorless learning of novel associations in amnesia.

In two experiments involving verbal association learning by people with memory impairments, the effectiveness of errorless learning (EL) was compared with errorful learning (EF). Experiment 1 examined the effectiveness of both methods in learning remotely linked word pairs. There was an advantage for items learned by EL at immediate test which was not sustained over a delay of 1 hr. Learning appeared to be stable over this delay in the EF condition. Analysis of responses at delayed cued recall showed more evidence of spontaneous recovery in EF than in EL. Elimination of these items from analysis resulted in a similar pattern of forgetting in both methods. Experiment 2 examined the effectiveness of EL and EF in teaching novel associations, and showed an advantage for EL at immediate and delayed test. Forgetting was apparently observed following EL, but not EF. As in Experiment 1, this discrepancy was attributed to recovered responses at delayed test in EF. Eliminating these responses showed a similar pattern of forgetting in both methods for items correctly recalled at immediate test. The study shows an advantage for EL techniques in learning novel associations. The two methods also differ in that learning via EF is associated with more spontaneous recovery.

Adult↗
PubMed1995

Focal retrograde amnesia following closed head injury: a case study and theoretical account.

In this paper we present data from a closed head injury patient who presents a striking example of what Kapur (Cortex 29, 217-234, 1993) has termed " focal retrograde amnesia". The patient, D.H., is unable to recollect any autobiographical incidents from the pre-morbid period, although he is able to provide personal and public information from this period. The data are discussed in relation to other reported instances of focal retrograde amnesia and a preliminary theoretical account is offered.

Adult↗
PubMed1995

The method of vanishing cues: an evaluation of its effectiveness in teaching memory-impaired individuals.

The method of vanishing cues and a standard rote learning method were used to teach a group of memory-impaired individuals a small computer vocabulary. Learning was observed using both teaching methods but no advantage was found for either one. A second experiment was carried out where modifications were made to the vanishing cues procedure in order to facilitate the use of implicit memory. Retention was significantly better following study with rote learning than with the modified vanishing cues procedure. A theoretical interpretation of these results and the reason for the failure to replicate previous findings is given.

Adult↗
PubMed1994

Aetiological variation in the amnesic syndrome: comparisons using the list discrimination task.

In this study, the performance of amnesic patients with presumed temporal lobe damage was compared with that of patients with presumed diencephalic damage using the temporal list discrimination task. The two patient groups performed similarly on a measure of recognition, but the diencephalic group was impaired relative to the temporal lobe group on a measure of temporal discrimination. Discrimination performance in the temporal lobe group was significantly correlated with recognition memory. The data are interpreted as showing a qualitative difference in the form of amnesia arising from damage centred on the medial temporal lobes compared with that centred on the midline diencephalon.

Adult↗
PubMed1994

Bilateral temporal lobe pathology with sparing of medial temporal lobe structures: lesion profile and pattern of memory disorder.

The lesion sustained by the amnesic patient H.M. consisted of bilateral ablation of medial temporal lobe structures with relative sparing of more lateral white matter and neocortical structures. We present the first detailed report of a case where the reverse pattern of lesions predominated, namely bilateral pathology of white matter and neocortical temporal lobe structures, with spared medial temporal lobe structures. This damage, which was particularly severe in anterior loci in the temporal lobes, was sustained as a result of radionecrosis. High-resolution magnetic resonance imaging was carried out to document the distinctive anatomical profile of our patient, and this profile was compared to that reported for the patient H.M. At the anatomical level, there was an almost "mirror image" profile, with contrasting involvement of lateral and medial temporal lobe structures. At the neuropsychological level, our patient was not amnesic but showed patchy impairment on traditional tests of anterograde memory functioning, in the context of notable "semantic" memory loss for knowledge acquired before and after the onset of his illness. Our findings demonstrate that bilateral temporal lobe pathology by itself does not lead to a classical amnesic syndrome, but may result in a significant but more subtle "semantic" memory loss. Our data highlight the distinctive and dissociable contribution of lateral and medial temporal lobe structures to human memory processing, and suggest a major role for anterior-inferior neocortical temporal lobe mechanisms in aspects of knowledge acquisition, storage and retrieval.

Amnesia↗
PubMed1994

Impairment of memory following discrete thalamic infarction.

This paper presents a case of discrete thalamic infarction which damaged various structures in the region of the left thalamus. Localisation of the lesion was confirmed by MRI scanning. From the localisation of the lesion it was concluded that damage has been inflicted on the hippocampal pathway, the amygdalar pathway, and the pathway from perirhinal cortex to the dorso-medial thalamic nucleus. Neuropsychological evaluation revealed a severe verbal memory deficit on anterograde tests comparable with that shown by alcoholic Wernicke-Korsakoff patients. In contrast performance on non-verbal memory measures was normal. Performance on retrograde amnesia tests indicated near-normal performance. A final finding was that memory for temporal information was impaired for both verbal and non-verbal information but only on anterograde tests. The data provide support for the view that a lesion in the anterior thalamus can produce amnesia if it compromises the hippocampal pathway and either the amygdalar pathway or that arising from the perirhinal cortex and terminating in the dorso-medial nucleus of the thalamus. On the basis of evidence from other studies it is concluded that the most likely interpretation is that the lesion must compromise the hippocampal and perirhinal cortex pathways. The pattern of memory impairment is described in some detail and these provide a basis for discussing the role of diencephalic structures in memory performance.

Amnesia↗
PubMed1993

Use of temporal context information in Alzheimer's disease.

Current theories of memory and memory dysfunction emphasize the importance of the use of contextual information in the storage and retrieval of specific episodes. Patients with lesions primarily in the diencephalon perform poorly on a measure of temporal recency, while those with temporal lobe amnesia are significantly better. The present study evaluated the ability of Probable AD patients to utilize information about temporal recency in the context of a recognition memory task. The performance of the AD patients was significantly impaired and resembled that of patients with Korsakoff's syndrome. The pattern of performance suggested that they were able to recognize which stimuli had been previously presented, but were unable to recall the correct temporal context. Further, there were no significant correlations between measures of temporal recency and those of frontal lobe function. These data suggest that AD patients, like other groups of patients with severe memory defects, are impaired at the use of context information in their attempts to remember recent events.

Aged↗
PubMed1993

Impaired temporal context memory on anterograde but not retrograde tests in the absence of frontal pathology.

This study examined the memory performance of patient RK who developed substantial memory impairments due to a hypothalamic glioma but in the absence of any evidence of frontal disturbance. RK was evaluated on both tests of anterograde and retrograde memory for temporal context. In the first experiment he exhibited marked deficits on a list discrimination task even when recognition performance was well within control range. Experiment 2 confirmed this disproportionate impairment of temporal order memory and showed that RK's list discrimination deficit was as severe as that found in alcoholic Wernicke-Korsakoff Syndrome patients. Experiment 3 showed that RK's temporal discrimination deficit was not a general deficit in discrimination because he performed normally on a spatial discrimination test of comparable difficulty to the temporal task. Experiment 4 examined RK's memory for deceased famous people and his ability to indicate the half decade in which they died. RK's performance was indistinguishable from controls whereas WKS patients were extremely impaired. This study adds to the view that frontal damage is not a necessary condition for impairment on anterograde measures of temporal context memory. However, further evidence from this study indicates that temporal judgments about pre-existing memories may depend on intact frontal lobe functioning.

Adult↗