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N M McGuire

Publications and source records attributed to N M McGuire.

7 recordsLinked to original sources

Monitoring in the field.

This review looks at the challenges faced when monitoring patients in the field environment. It is considered from the perspective of the UK Defence Medical Services and their experiences over the past 20 yr. The lessons learned are applicable to many other circumstances where a high standard of care, for a large spectrum of patients, is to be delivered in the most inhospitable conditions. The environmental influences on monitoring equipment such as extremes of heat, cold and altitude must be considered and dealt with. Minimal monitoring standards required by professional bodies have to be undertaken, but there is a need to exceed them to compensate for the untoward effects of hostile environments. Patient and machine variables monitored and their relative importance in the field are also explored. Varying field locations are illustrated and the types of monitoring required to care for patients in different areas of field units are discussed. Patient transfers and the particular difficulties encountered in the military context are also reviewed. Undertaking aeromedical evacuation is one of the most challenging environments in the field and the solutions required to undertake it are explored. These considerations are used to propose design requirements necessary to provide appropriate monitoring in all other field conditions. The standards set for carriage of equipment in the air and the testing required allowing compliance with the regulations in force in the UK, are outlined. Finally the importance of practitioner training to undertake these roles in the field is discussed.

Air Ambulances↗

Laboratory assessment of the Bird T-Bird VS ventilator performance using a model lung.

We assessed the Bird T-Bird VS ventilator using a model lung constructed to standard 10651-1 of the International Standards Organization. We used different combinations of lung compliance and airway resistance to simulate normal and diseased adult and paediatric lungs. Different preset tidal volumes at various respiratory rates were delivered to the model lung and compared with the actual measured tidal volumes. The results showed that the delivered tidal volumes were within the manufacturer's specification of +/- 10% of the preset tidal volumes in normal adult and paediatric combinations of lung compliance and airway resistance. The ventilator can be powered by mains electricity supply or battery and requires only optional compressed oxygen. The ventilator is suitable for the provision of advanced ventilatory support during prolonged patient transfer.

Adult↗

Rapid prenatal diagnosis of chromosomal aneuploidies by fluorescence in situ hybridization: clinical experience with 4,500 specimens.

Detection of chromosome aneuploidies in uncultured amniocytes is possible using fluorescence in situ hybridization (FISH). We herein describe the results of the first clinical program which utilized FISH for the rapid detection of chromosome aneuploidies in uncultured amniocytes. FISH was performed on physician request, as an adjunct to cytogenetics in 4,500 patients. Region-specific DNA probes to chromosomes 13, 18, 21, X, and Y were used to determine ploidy by analysis of signal number in hybridized nuclei. A sample was considered to be euploid when all autosomal probes generated two hybridization signals and when a normal sex chromosome pattern was observed in greater than or equal to 80% of hybridized nuclei. A sample was considered to be aneuploid when greater than or equal to 70% of hybridized nuclei displayed the same abnormal hybridization pattern for a specific probe. Of the attempted analyses, 90.2% met these criteria and were reported as informative to referring physicians within 2 d of receipt. Based on these reporting parameters, the overall detection rate for aneuploidies was 73.3% (107/146), with an accuracy of informative results for aneuploidies of 93.9% (107/114). Compared to cytogenetics, the accuracy of all informative FISH results, euploid and aneuploid, was 99.8%, and the specificity was 99.9%. In those pregnancies where fetal abnormalities had been observed by ultrasound, referring physicians requested FISH plus cytogenetics at a significantly higher rate than they requested cytogenetics alone. The current prenatal FISH protocol is not designed to detect all chromosome abnormalities and should only be utilized as an adjunctive test to cytogenetics. This experience demonstrates that FISH can provide a rapid and accurate clinical method for prenatal identification of chromosome aneuploidies.

Adult↗

Septic arthritis in the elderly.

The clinical and microbiologic features of septic arthritis in 23 elderly patients are reviewed. Fifteen patients had pre-existing joint diseases, predominantly osteoarthritis and rheumatoid arthritis. Eight patients had underlying systemic illnesses, and eight patients were receiving systemic corticosteroid therapy prior to the development of septic arthritis. The knee was the joint most commonly infected. Although Staphylococcus aureus was the major pathogen (52.2 per cent of patients), enteric gram-negative bacilli were found in seven of 23 patients (30.4 per cent). Five patients died (21.7 per cent mortality), two as a result of their infection and three of nosocomial Pseudomonas sepsis. Eight of the 18 survivors (44.4 per cent) developed osteomyelitis in the contiguous bone. Return of joint function was slow in all patients. Septic arthritis in the elderly is difficult to treat and has a poor outcome, possibly because pre-existing joint disease is very common and enteric gram-negative bacilli are often the causative organisms.

Aged↗

Evaluation of the BACTEC antimicrobial removal system for detection of bacteremia.

The BACTEC 16B resin medium was developed to detect bacteremia in patients receiving antimicrobial therapy. Over a 9-month period, we compared the efficacy of the BACTEC 16B bottle to the conventional aerobic BACTEC 6B bottle. Of a total of 1,524 sets of blood cultures, 79 yielded presumed pathogens. Of these 79 sets, 42 (53.2%) were positive in both the 16B and 6B bottles, 23 (29.1%) were positive only in the 16B bottle, and 14 (17.7%) were positive only in the 6B bottle. For patients receiving antimicrobial drugs, 33 of 34 (97.1%) sets were positive for pathogens in the 16B bottle, but only 15 of 34 (44.1%) were positive in the 6B bottle. In 19 (55.9%) of the 34 sets, only the 16B bottle yielded growth. The resin bottle was more useful for patients with gram-positive bacteremia than for those with gram-negative bacteremia. The BACTEC 16B resin medium increases the recovery of organisms from bacteremic patients receiving antimicrobial agents and should be used in addition to the standard BACTEC aerobic bottle for such patients.

Culture Media↗