PubMed Health⌕ Search

Biomedical subjects

N M Tkachenko

Publications and source records attributed to N M Tkachenko.

At least 19 recordsLinked to original sources
PubMed1995

[Effects of sex hormones on systemic reactions of the brain in women of different age].

Comparative analysis of electroencephalograms (EEG) and brain reactions to single and rhythmic photostimulation in 40 girls aged 9 to 17 with ovarian aplasia or hypofunction, 39 women of a reproductive age with ovarian exhaustion, and in 305 experimental animals aged 2 to 60 days with changed levels of estrogenic hormones showed that such changes influenced the formation of cerebral response starting from the age of 14-15 in humans and from days 15-20 in animals. The general trend of the electrical activity of the brain in hormonal deficiency manifested in all the groups by changed function of the activating brain structures. An increase of estrogen level at the age of 14-15 (in girls) and 20-30 days (in animals) caused the appearance of convulsive activity on the background EEG and an increase of rhythmic discharges of afteraction in the evoked potential. A definitive pattern of systemic reactions of the brain to changes in estrogen level was observed in girls aged 16-17 and in experimental animals aged 46-60 days.

Adolescent↗
PubMed1995

[The pathological mechanisms of the intermenstrual pain syndrome].

Comprehensive clinicophysiological examinations of 80 patients suffering from the intermenstrual pain syndrome revealed organic changes in the pelvic organs of 92.5% of women and disturbances in the central structures participating in the conduction and control of pain sensitivity and vasomotor regulation in all the examinees, these changes correlating with specific vegetovascular and psychoemotional disorders. Three pathogenetic variants of development of this syndrome were defined.

Adult↗
PubMed1994

[Autonomic nervous system activity during the normal menstrual cycle].

Body adaptation reactions to changes of the internal conditions (neurohumoral shifts related to ovulation and corpus luteum development) were studied in 15 women of a reproductive age with normal biphasic cycle in the early follicular and medium lutein phases on the basis of mathematical analysis of heart rhythm, a number of cardiovascular and respiratory system parameters, and brain electric activity. Moderate tension of the regulatory mechanisms in the lutein phase of the cycle was protective and adaptive and probably related to body preparation to a would-be pregnancy. These adaptive effects are different in different women: in some internal environment parameters vary within a wide spectrum, in others these parameters show a trend to retain their functioning regimen.

Adaptation, Physiological↗
PubMed1993

[The pathogenetic mechanisms of hyperthermia in patients with the premenstrual syndrome].

Functional status of the central and autonomic nervous system was analyzed in 28 patients with the premenstrual syndrome one of whose manifestations was disordered thermoregulation. The examinations were carried out during both cycle phases. Analysis of the EEG data and clinical findings has shown different patterns of autonomic thermoregulation disturbances in three groups of patients and permitted the authors to suggest that changed activity of certain neurotransmitter systems connected with hormonal secretion over the course of the cycle was responsible for these disturbances.

Adolescent↗
PubMed1992

[Cerebrovascular circulation in patients with oligomenorrhea].

Brain hemodynamics was studied in 76 patients with oligomenorrhea aged 18 to 35 from the data of rheoencephalography. Disorders of the regional tone of brain vessels were different and related to the time of the menstrual cycle disorder; this may be explained by the degree of changes in various neuromediator mechanisms of brain circulation and reproductive system function regulation.

Adolescent↗
PubMed1992

[General principles of the pathogenesis of vegetovascular and psychoemotional disorders during menstrual cycle and methodological approaches to their study].

Analysis of charts filled in by 79 women (mean age 31.5 +/- 4.0 years) over the course of 2-3 menstrual cycles has demonstrated the regular manifestation of various psychosomatovegetative symptoms over the entire course of the cycle (in the follicular, lutein phases, and during ovulation). Study of the brain electric activity and of the function of various sections of the autonomic nervous system, as well as examination of the emotional and mental sphere of the patients has revealed the contribution of the brain suprasegmental sections to the pathogenetic mechanisms of these disorders.

Adult↗
PubMed1991

[Characteristics of the functional state of the central nervous system in women during the menstrual cycle and in premenstrual syndrome].

Electroencephalographic examination of the function of the central nervous system in 30 healthy women and in 15 ones suffering from the premenstrual syndrome, carried out over both phases of the menstrual cycle, has revealed clear-cut differences between the two groups. 46% of the patients developed pathologic shifts at the level of the brain stem, 37% of the hypothalamic level, and 17% combined involvement of these portions of the brain. Triggering of the compensatory defense mechanisms already during the follicular phase of the cycle indicates failure of the adaptation mechanisms in the patients with the premenstrual syndrome.

Adult↗
PubMed1991

[Characteristics of the functional state of different sections of the autonomic nervous system and their role in the pathogenesis of oligomenorrhea].

Analysis of the clinical picture of oligomenorrhea and of the results of studies of the function of various sections of the autonomic nervous system (ANS) in 58 patients of a reproductive age has revealed differences in these functions, related to the time of menstrual disorders onset. Oligomenorrhea patients with menarche complained of cardiovascular, respiratory, and emotional-motivational disorders, examinations have revealed in them dysfunctional disorders and reduced reserve potentials of both ANS sections. In oligomenorrhea patients in whom the condition developed at the age of 18-25 after a period of regular menstruations the effects of various stress factors resulted in reduction of the functional activity of the ergotropic (sympathoadrenal) section of the ANS. Differences in the pathogenetic mechanisms of oligomenorrhea development in the two groups of patients are discussed.

Adolescent↗
PubMed1990

[The hypothalamo-hypophyseal system in resistant ovary syndrome].

The study has been done in 30 women with the resistant ovary syndrome diagnosed by laparoscopy, laparotomy and histologic examination of ovarian biopsy samples. Genetic study identified the feminine phenotype and genotype (46,XX). Estradiol levels corresponded to those seen in the follicular menstrual phase, prolactin levels were normal, and gonadotropin levels were above basal values and were several fold above the ovulatory peak, when tested with luteinizing hormone-releasing factor in 7 patients and after estrogen challenge in 5 patients. The tests indicated an adequate adenohypophyseal response and intact feedback mechanisms between the hypothalamic pituitary system and gonadal steroids, as confirmed by electroencephalography.

Adult↗