[Substantiation of the maximum permissible concentration of para-aminophenol in the air of industrial establishments].
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Biomedical subjects
Publications and source records attributed to N M Vasilenko.
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It is determined that ortho- and n-nitrophenol introduced into the stomach (0.80 and 0.11 g/kg, respectively) inhibit the activity of cytochrome oxydase (by 21% at an average), cause an increase in the content of NADH (by 35 and 27%) and a decrease in ATP (by 38 and 36%, respectively), split the oxidation and phosphorylation processes in the rat liver tissue. The content of NAD+, AMP and ADP, lactate, the activity of K+, Na+-ATPase and lactate dehydrogenase do not change.
It has been established in experiments on white rats that administration of acetylsalicylic acid (ASA) in a dose of 1/10 LD50 for 1 1/2 months is accompanied by a decrease in the functional activity of spermatozoids. Repeated inhalation of ASA dust at a concentration of 25 mg/m3 for 4 months produces morphological changes in the spermatogenic epithelium and abnormal antenatal development of the progeny of male animals under test.
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