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N MacLeod

Publications and source records attributed to N MacLeod.

5 recordsLinked to original sources
PubMed1989

The influence of the estrous cycle on the activity of striatal neurons recorded from freely moving rats.

Recordings from striatal neurons in conscious rats at various stages of the estrous cycle revealed differences in the activity of the neurons. Average firing rate was higher in diestrus than in animals in estrus or proestrus. The increase did not seem to depend on the motor activity of the animals nor was it present in ovariectomized rats. Since application of estrogen to ovariectomized rats did not change the firing rate of the neurons, we conclude that differences during the cycle in conscious rats are not mediated by an action of estrogen unlike those seen in anesthetized rats. Differing electrode sampling bias in the two situations, or an action of anesthetic in revealing the estrogen effect may explain the differences.

Action Potentials↗
PubMed1989

Triazolam.

Explore the source record for details and available documents.

Humans↗
PubMed1985

Electrophysiological properties of single units in dopamine-rich mesencephalic transplants in rat brain.

Electrophysiological recordings were made from grafts of embryonic ventral mesencephalon transplanted into the neocortex, overlying the host neostriatum of rats in which the intrinsic striatal dopamine (DA) innervation had been removed by a unilateral 6-hydroxydopamine (6-OHDA) lesion. Whereas all rats had surviving grafts, half of the rats showed recovery from amphetamine-induced rotational asymmetry induced by the 6-OHDA lesions ('compensation'), indicating a functional dopaminergic reinnervation of the host striatum by the graft. The electrophysiological recordings revealed: neurons within all grafts which could be antidromically activated from host striatum, and which had faster conduction velocities and narrower action potentials than is characteristic of DA neurons in the intact substantia nigra, neurons only within the grafts of compensated rats which had properties characteristic of normal nigral DA neurons, and neurons within the grafts which responded to stimulation of the frontal cortex and lower brainstem of the host. The data support the view that the grafts can establish physiologically functional afferent and efferent connections with the host brain.

Animals↗