Biomedical subjects

N Madle-Samardzija

Publications and source records attributed to N Madle-Samardzija.

At least 19 recordsLinked to original sources

PubMed1995

[Bacterial meningitis with a low leukocyte count at the beginning of hospital treatment].

The clinical pictures and the course of bacterial meningitides in 7 patients with leukocytes in the peripheral blood below 6.0 x 10(9)/l was examined out of 7 patients 6 were female and 1 male, from 7 months to 56 years of age, the mean age X = 22.3 years. At the beginning of the hospital treatment, patients from this group were more frequently afebrile or subfebrile (5 patients) meningitic signs significant (4 patients). Parameters of nonspecific inflammatory response in blood, SE and fibrinogenaemia were less expressed, while the response in liquor to bacterial infection was normal. Gram-negative bacteria were more frequently isolated among etiologically established causes of meningitides. In patients with leukocytes below 6.0 x 10(9)/l, purulent meningitides were more often serious and very serious diseases (4). There were no complications in some patients and 5 patients were completely cured (71.42%), while in 2 patients (28.58%) there was a mild hyperproteinorrachia in the liquor at the time of leaving hospital.

Adolescent↗

PubMed1995

[Leptospirosis at the Clinic for Infectious Diseases in Novi Sad 1984-1993].

We examined the clinical picture and course of leptospiral infections in 50 patients treated at the Clinic during the period 1984-1993. Most patients were 11-20 years of age (9 years the youngest and 77 years the oldest, mean age being 25.16). The disease more often occurred in male patients, 44 (88%). There were 30 (60%) patients with gastrointestinal symptoms, while 21 (42%) had liver and kidney infections. Meningeal syndrome was established in 25 (50%) and serous meningitis in 13 (26%). Leptospiral infections represented average and serious infections with complications in 8 (16%) patients, successful treatment in 47 (94%) patients while 3 (6%) patients died due to hematorenal insufficiency.

Adolescent↗

PubMed1995

[Hemorrhagic fever with renal syndrome in Vojvodina].

This paper presents 4 serologically confirmed cases of hemorrhagic fever with kidney syndrome. The objective of this study was to point to occurrence of unexpected hemorrhagic fever with kidney syndrome, to different clinical pictures and differential-diagnostic difficulties as well as to therapeutic procedures of serious cases. The disease had a sudden onset with general signs of infection in all our patients. 3 out of 4 patients had had a dominant symptomatology in regard to gastrointestinal tract, whereas signs of acute renal insufficiency appeared later. In 3 patients there was a complete recovery without consequences, while one female patient died on the twelfth day of the disease.

Adult↗

PubMed1995

[The Epstein-Barr virus and chronic fatigue syndrome].

Lately discovered chronic fatigue syndrome is associated with Epstein-Barr virus infection. The objective of this paper was to detect this syndrome in our patients. 31 patients with cured acute infective mononucleosis were examined by questionnaire, physical check-up and laboratory analyses in order to detect disorders characteristic for chronic fatigue syndrome. Six months after they had been cured, out of 7 patients 5 patients complained of frequent sore throat, fatigue and exhaustion, and a year later, all 5 patients were sleepy and tired all the time. More than a year after the acute illness 19 patients were examined and in 5.6% frequent sore throat and enlarged neck lymph nodes occurred. The gathered results point to disorders characteristic for chronic fatigue syndrome in a high percentage. This pilot study should only be the beginning of examinations of this kind.

Acute Disease↗

PubMed1995

[Intrathecal synthesis of immunoglobulin G in patients of various ages with acute viral meningitis and meningoencephalitis].

Intrathecal antibody synthesis is a common local immunologic reaction in acute meningoencephalitis and encephalitis caused by Herpes group viruses, myxo and paramyxoviroses. The purpose of this study was to determine the quantity of de novo synthesized IgG during 24 hours in the liquor of patients of different ages suffering from acute viral meningitis and meningoencephalitis and to establish correlations between the dysfunction of blood-brain barrier and de novo IgG synthesis. We examined 73 patients of different ages divided into 5 groups according to their age. The state of blood-brain barrier was the most stable with high Qalb values of 225,596 for the youngest (from 2 to 6) and 193,190 for the somewhat older children (from 7 to 15). The most common damage of the blood-brain barrier was established in the oldest group of patients--over 40 years of age. The lowest intrathecal IgG production was established in the youngest group from 2 to 6 (6.631 mg/24 hours), and the highest (64.61 mg/24 hours) at the beginning of the disease in the group from 16 to 25 years of age. We established a correlation between damages of blood-brain barrier and de novo synthesis of IgG, especially in the youngest patients in the first days of the disease as well as 14 and more days later, when a low immunoglobulin production was established but a well preserved blood-brain barrier too. In the group of patients older than 40 years of age such a correlation was not found which points to a tissue synthesis of antibodies in the central nervous system.

Acute Disease↗

PubMed1994

[Therapy of salmonella gastroenterocolitis].

At the Clinic for infectious and dermatovenerologic diseases in Novi Sad a prospective randomized, simple, blind investigation of differently organized treatments of salmonellal gastroenterocolitis (symptomatic therapies, ampicillin, co-trimoxazole and ciprofloxacine) was carried out. It was established that there is no statistically significant difference in the length of febrile states in any of the compared therapeutic groups. However, ciprofloxacine significantly shortens diarrhea and excretion of germs comparing with other therapeutic treatments.

Adolescent↗

PubMed1993

[Etiologic structure and clinical characteristics of acute viral infections of the central nervous system with hyperproteinorachia].

Clinical syndrome of acute viral meningitis and meningoencephalitis may be induced by different viruses. Etiologic diagnosis may be set by the isolation of the virus from the liquor and by the detection of specific antibodies in the blood and liquor. Our aim was to determine viral etiology of AVI with special reference to hyperproteinorachia. The study was conducted in 55 patients treated at the Clinic of Infectious Diseases in Novi Sad, with clinical picture of acute meningitis or meningoencephalitis, with pleocytosis above 50 ml in the cerebrospinal fluid. Depending on the levels of proteinorachia the patients were divided into the group with proteinorachia levels below 1g/l (34 patients) and above 1 g/l (21 patients). In the first group the most common was herpes simplex- and adenoviral etiology while in the second group most frequently found were choriolymphocytic meningitis virus (LCM) and herpes simplex virus. The protein level was in correlation with the severity of the clinical features and the duration of the treatment.

Acute Disease↗

PubMed1993

[Meningococcal sepsis and difficulties in differential diagnosis--case report].

We report a case of meningococcal sepsis in a healthy immunocompetent sixteen year old boy who had developed upper respiratory tract acute infection 10 days before the admittance. Clinical manifestations were similar to those found in allergic hemorrhagic purpura (Schonlein's form of the disease). The clinical course of these two diseases is usually different but sometimes they cannot be easily differentiated. The acute onset of polyarthritis, temperature and skin manifestations in the form of erythematous maculopapular exanthema which within several hours evolved into hemorrhagic purpura is typical for the sepsis caused by Neisseria meningitides but these characteristics might be found in allergic Henoch-Schonlein' purpura as well. In our case the accurate diagnosis was set by the identification of the group C Neisseriae meningitides from the patient's blood. The first choice was penicillin therapy.

Adolescent↗

PubMed1993

[Sensorineural impairment in the inner ear in epidemic parotitis].

During morbilli and mumps, classical forms of acquired deafness develop in childhood. The aim of the study was to investigate effects of mumps virus on cochlear function. Of 237 examined patients 71 had parotitis and 166 meningitis-meningoencephalitis. Audiometric analyses were carried out at the beginning of the treatment and after 6 months. Hearing loss above 30 dB was found in 109 patients (45.99%). Mild hearing impairment of sensorineural type was registered in the majority of patients, while total one-sided hearing loss was found in 2.53% of subjects. No correlation between clinical manifestations of parotitis or meningoencephalitis and hearing loss was found. Cytochemical liquor levels did not influence the development of hearing loss. 6 months later a recovery followed mainly in patients with mild impairments.

Hearing Loss, Sensorineural↗

PubMed1992

[The role of Epstein-Barr viruses as etiologic agents in the mononucleosis syndrome].

Mononucleosis syndrome represents a number of symptoms with different etiology and pathogenicity with similar clinical features. The aim of the study was to investigate etiologic structure of mononucleosis syndrome, effects of etiologic factors and age on the severity of clinical features, clinical forms of the disease, complications and the outcome. The investigation was conducted in 46 patients treated at the Clinic who had been diagnosed as having mononucleosis syndrome. EBV-IM was confirmed in 43%, adenoviral IM in 13%, while in 44% of the patients etiology of the disease was not established. In both groups more severe forms were present in patients over 16 years of age, but more frequently in EBV-IM than in other patients with mononucleosis syndrome (40% vs 19.23%). Complications in the form of acute hepatitis were found only in patients with EBV-IM in 20% of the cases, mean age 17 years. We are of the opinion that EBV is a significant etiologic agent in mononucleosis syndrome, that the disease is more severe in older patients who also develop complications. The outcome for all the patients was favorable.

Adolescent↗

PubMed1992

[Abdominal typhus today].

Abdominal typhus is all the rearer disease among acute infectious diseases in Vojvodina. In the last ten years (1981-1990) 16 patients with abdominal typhus were treated at the Department of Infectious Diseases in Novi Sad, mostly young individuals from 6 to 30 years of age (13 patients). Positive epidemiologic features were found in 13 patients. In 80% of the cases the source of infection was outside Vojvodina. They usually were admitted at the Department on the first and second week of the disease (11 patients), and 3 patients were admitted on the third week. None of the patients was suspected of having abdominal typhus at the time of admittance. Delayed hospitalization and unrecognized abdominal typhus were most likely due to the atypical onset and course of the disease. Atypical features in the clinical picture occurred in all the patients with a sudden onset of the disease. The abrupt temperature elevation in 50% of the patients was followed by shivering, fever and shaking. Hepatosplenomegaly was found in 12 patients, abdominal meteorism in 10, typical typhus tongue in none. Typhus state was not found in any of the patients. Normal leucocyte count was found in 7 patients, positive Widal's agglutination reaction in 13, coproculture in 8 and hemoculture in 15 patients. The atypical clinical picture was the result of early administration of broad-spectrum antibiotics before the established etiology of the febrile state.

Adolescent↗

PubMed1992

[Pneumococcal meningitis from 1974 to 1984].

We examined a group of 22 patients presented with the acute infective meningeal syndrome. Lumbar punction confirmed diagnosed purulent meningitis--meningoencephalitis, and bacteriologic liquor culture identified Streptococcus pneumoniae as a cause of the disease. Patients were mostly aged over 30. Clinical picture revealed signs of general infection and the meningeal syndrome. The severity of the disease was assessed on the basis of apparent signs of general infection, state of consciousness and endotoxic shock symptoms. Severe consciousness disorders were present in 16 (72.72%) patients. In our patients possible pneumococcus infection foci were: sinusitis, otitis media, pneumonia, mastoiditis and adnexitis. Lethal outcome occurred in 5 (22.72%) patients. In the therapy we used penicillin, chloramphenicol and ampicillin along with corticosteroid administration.

Adult↗

PubMed1991

[Mumps infection and disorders of glucose tolerance].

In the last few years there is a more frequent appearance of papers which suggest the viral etiology of juvenile diabetes mellitus, where the mumps virus is primarily pointed to as the etiological factor. Since there is a high incidence of diabetes in our Province as well as the presence of an epidemic appearance of mumps infections, we were of the opinion that there was good reason for us to study the influence of mumps infection on glucose tolerance. With our research we have proved that mumps leads to the disturbances of carbohydrate metabolism and this is the case not only in the acute stage of infection but also in the course of a two-year follow-up, and they develop as a consequence of the direct influence of the virus on the beta cells of the pancreas. Glucose tolerance disturbances were not in correlation with the changes on the exocrine part of the pancreas neither in the acute stage nor in reconvalescence. Hereditary factors also didn't influence the more frequent appearance of these disturbances in persons with a hereditary disease, which was confirmed statistically also (X2 = 0.67). By research we have proved that disturbances which take the course of the "slow virus infection" type also occur and that they are statistically more significant (X2 = 22.31) in relation to the glucose tolerance disturbances which develop due to a direct activity of the mumps virus.

Acute Disease↗

PubMed1986