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Biomedical subjects

N Maleki

Publications and source records attributed to N Maleki.

4 recordsLinked to original sources

A system for stereotactic radiosurgery with a linear accelerator.

A small field irradiation technique to deliver high doses of single fraction photon radiation to small, precisely located volumes (0.5 to 8 cm3) within the brain has been developed. Our method uses a modified Brown-Roberts-Wells (BRS), CT-guided, stereotactic system and a 6 MV linear accelerator equipped with a special collimator (diameters of 12.5 mm to 30.0 mm projected to isocenter) located 23 cm from isocenter. Target localization via planar angiography has been added. Treatment consists of a series of arcing beams using both gantry and couch rotations. During treatment, the patient's head is immobilized independently of the radiotherapy couch and is precisely positioned without reference to room lasers or light field. A precise verification of alignment precedes each treatment. Extensive performance tests have shown that a target, localized by CT, can be irradiated with a positional accuracy of 2.4 mm in any direction with 95% confidence. If angiography is used for localization, the results are better. The dose 1.0 cm outside the target volume is less than 20% of the prescribed dose for a medium sized collimator.

Brain Neoplasms

Transmission block to simplify combined pelvic and inguinal radiation therapy.

A homogeneous dose distribution of radiation to inguinal lymph nodes and deep pelvic structures can be achieved with use of a transmission block over the central portion of a large anterior pelvic-inguinal portal, together with a smaller posterior field. This relatively simple technique permits individualization of isodose distributions and eliminates the problems of matching abutting portals. Reproducibility of daily setup and optimization of machine utilization are both improved.

Dose-Response Relationship, Radiation

Microdensitometry using a slide projector.

We have evaluated a simple microdensitometer concept by Stanton et al. for measurements of dose distributions with high spatial resolution. A magnified image of the film is created by a slide projector and its light intensity measured with a photomultiplier with a small aperture. The projector is placed on a movable stage to allow scanning of the film. A resolution of 17 micron (full width at half maximum of the line spread function) was achieved in the film plane.

Absorptiometry, Photon

Evaluation of a beam-spot camera for megavoltage x rays.

A beam-spot camera for measurements of x-ray focal spots of accelerators has been evaluated. The device consists of closely packed 0.25-mm-thick lead and 0.25-mm-thick cardboard strips. It is placed on radiographic film with the lamellae parallel to the beam axis and an exposure made. The images were scanned with a microdensitometer. The results indicate that the broadening of the source intensity profile at half maximum is of the order 1 mm, which permits the use of the beam-spot camera for acceptance testing and quality control. Longer tails in the density profile limit the quantitative information that can be extracted from the images.

Cobalt Radioisotopes