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Biomedical subjects

N Muto

Publications and source records attributed to N Muto.

At least 109 records · Page 6Linked to original sources
PubMed1980

Role of adrenergic agonists on gastric secretion in the rat.

Following previous demonstration that isoproterenol stimulated and norepinephrine inhibited gastric acid secretion induced by secretagogues, role of adrenergic agonists was studied by measuring acidity the peptic activity of the effluent of the perfused rat stomach. Response of gastric secretion to isoproterenol was increased by theophylline treatment but was not affected by metiamide treatment. N6, O2'-Dibutyryladenosine 3', 5'-cyclic monophosphoric acid sodium salt monohydride (dibutyryl-c-AMP) stimulated gastric secretion in a dose-dependent manner. These results suggest the possibility that the action of isoproterenol in gastric acid secretion is mediated by c-AMP. However, gastric secretion induced by pentagastrin, histamine, or carbamylcholine was not affected by theophylline treatment. N2, O2'-Dibutyrylguanosine 3', 5'-cyclic monophosphoric acid sodium salt (dibutyryl-c-GMP) did not exert any effect on gastric secretion. Depression of pentagastrin-induced gastric secretion by norepinephrine was reversed by EGTA infusion. Moreover, Ca2+, depressed pentagastrin-induced gastric secretion. These results suggest that the action of norepinephrine is closely related to the concentration of Ca2+.

Adrenergic alpha-Agonists↗
PubMed1980

Mycinamicins, new macrolide antibiotics. I. Taxonomy, production, isolation, characterization and properties.

Mycinamicins, novel macrolide antibiotics were obtained from the culture broth of Micromonospora grisseorubida sp. nov. Isolation of five components, mycinamicins I, II, III, IV and V, was accomplished by silica gel adsorption or partition chromatography. Mycinsmicin I and II exhibit a strong UV absorption peak at 218 nm and have a shoulder at 240 nm. Mycinamicin III, IV and V show strong UV absorption peaks at 215 nm and around 280 nm. From their physicochemical and biological properties, the mycinamicins are classified as new macrolide antibiotics.

Anti-Bacterial Agents↗
PubMed1979

Purification and characterization of rat pepsinogens whose contents increase with developmental progress.

Two pepsinogens, the contents of which increase with developmental progress, were purified from the gastric mucosa of the adult rat by ammonium sulfate fractionation and chromatography on DEAE-cellulose and DEAE-Sepharose CL-6B columns. The purified zymogens, designated as pepsinogens I and II, were each shown to be homogeneous by polyacrylamide gel disc electrophoresis. Pepsinogen II had a greater electrophoretic mobility toward the anode at pH 8.0 than pepsinogen I. The molecular weights of both zymogens were estimated to be 38,000 by SDS-polyacrylamide gel electrophoresis. The activated enzymes, pepsins I and II, each had the same molecular weight of 32,000. The pH optima for both enzymes were found to be 2.0. The enzymes showed high stabilities at pH 8.0, while they lost their activities within 60 min at pH 10.0. The enzymes were inhibited by pepstatin and diazoacetyl-DL-norleucine methyl ester (DAN). The activities of the enzymes in hydrolyzing N-acetyl-L-phenylalanyl-3,5-diiodo-L-tyrosine (APDT) were about 1/8 of that of porcine pepsin. These results suggest that pepsins I and II are very similar.

Animals↗
PubMed1979

[General pharmacology of cefadroxil (author's transl)].

The general pharmacological properties of cefadroxil which is a new semisynthetized cephalosporin were examined and following results were obtained. 1) Cefadroxil had no appreciable influences on the central nervous system in mice and the EEG in cats. 2) Cefadroxil had no effects on the isolated smooth muscle organs. 3) Cefadroxil had no effects on the passage of charcoal meal in mice and the motility of the stomach in situ in rabbits. 4) Cefadroxil inhibited the gastric secretion in pylorus-ligated rats. 5) Cefadroxil induced no marked changes in the respiration, blood pressure, heart rate, electrocardiogram and femoral blood flow in anesthetized dogs. Cefadroxil had no effects on the isolated hearts and ear vessles of rabbits. 6) Cefadroxil decreased the urine volume and the excretion of electrolytes (Na+, K+ and Cl-) in first three hours in rats. 7) Cefadroxil increased the biliary secretion in rats. No significant effects of cefadroxil were found in the other pharmacological experiments.

Animals↗
PubMed1975

The effect of dipyridamole on the coronary hemodynamics in man.

The effects of dipyridamole (Persantin) on the coronary blood flow (the great cardiac vein flow and coronary sinus ostial flow), the femoral arterial pressure, the coronary vascular resistance and the heart rate were measured continuously in man. The newly devised method of the continuous local thermodilution method enabled us to perform the exact measurement of the above mentioned variables in man. The increase of the coronary blood flow was seen definitely in the non-ischemic group and, therefore, the decrease in the coronary vascular resistance occurred in 30 sec and continued for more than 20 min. In the myocardial ischemic group, some patients showed the similar response to the non-ischemic group. However, some patients showed no increase of the flow, even though the coronary vascular resistance decreased in all cases in this group. The heart rate increased slightly in all cases.

Acute Disease↗
PubMed1975

Inhibition of serum alkaline phosphatase activity by phenylalanine and cholic acid.

Serum alkaline phosphatase activity was found to increase more markedly in patients with liver cirrhosis than in patients with peptic ulcer and this increase was found to be influenced by blood types. After testing several amino acids and bile acids, phenylalanine and cholic acid were chosen and their inhibitory effects upon serum alkaline phosphatase activity were studied in 66 patients with various liver diseases. It was found that the combination of both agents demonstrates different patterns of inhibition between the patients with liver cirrhosis and obstructive jaundice. This inhibitory effects were also variable among cases of different blood types. Basing upon the present observation, the possible source of the elevated alkaline phosphatase activity in liver cirrhosis was discussed.

Alkaline Phosphatase↗