Biomedical subjects
Publications and source records attributed to N N Bogdanov.
We studied the effect of hypobaric hypoxia on mice with various brain weights. Mice with low brain weight were more resistant to hypoxia than animals with high brain weight.
An attempt was made to approach to the causes of the development of epileptic disorders from general biologic positions and to determine the signs of a normal organism, that might help to predict a risk of the disease manifestation. A pattern of electric activity of the brain of the animals, both sensitive and resistant to convulsive agents' action in terms of the influence of convulsive and anticonvulsive preparations on EEG are presented. A role of the brain's mass and of the peculiarities of dermatoglyphics as the predictors of the development of epileptic disorders are also discussed.
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This study is an attempt to analyze the relationships between EEG and dermatoglyphic patterns (DP) in 6-8 years girls. EEG-mapping was carried out in 80 healthy girls with different types of DP in 6 frequency band: delta, theta, alpha-1, alpha-2, alpha-3 and beta. Certain connection of the palmar and finger patterns with the EEG characteristics was revealed. The most pronounced differences were observed between subgroups with prevalence (8 and more) or absence of whorls on their hands fingertips, and between groups with presence or absence of certain pattern (whorl, loop or vestige) on thenar/interdigital 1 area (Th/1). Significant (p<0.05) increase of spectral density in alpha-2 and alpha-3 bands in children with whorls on hand fingertips were revealed in the first case. EEG of children with Th/1 pattern differed from the group without such pattern by increased spectral density in alpha-2, alpha-3 and beta bands. The new data obtained support the genetic determination of the EEG.
The seizure sensitivities to pentylenetetrazol (Ptz, 25-100 mg/kg) and strychnine (S, 2 mg/kg) were tested in two mice lines selected for large (LB) and small (SB) brain weight (brain weight difference being approximately 75 mg). The selection was based on a regression line connecting body and brain weight. SB mice were more sensitive to both drugs-their seizure latencies were shorter and lethality higher than in LBs. The seizures generated by Ptz and S are known to affect different neurotransmitter systems. The interstrain differences in seizure susceptibility are probably determined by SB mice nervous system traits rather than by differences in the particular neurochemical trait. The data on neocortical cytoarchitectonics obtained during our previous brain selection experiment could serve as the indirect evidence favouring such a suggestion.
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Dermatoglyphic studies showed that children with the Williams syndrome had certain peculiarities of morphological as well as behavioral character. The findings suggest that the syndrome can be regarded as a genetical model of the right brain dominance.
The effects of buspirone (5 and 10 mg/kg i.p.), 8-OH-DPAT (0.25 mg/kg) and raclopride (2.5 mg/kg) on the EEG power spectra of the sensorimotor cortex were studied in freely moving rats. Buspirone (5 mg/kg) and 8-OH-DPAT produced selective slowing of the theta-activity. Buspirone (10 mg/kg) produced slowing of the theta-activity and increased the power of the alpha-band (9-11 Hz). Raclopride alone did not influence EEG power spectra. Simultaneous injection of 8-OH-DPAT and raclopride produced marked slowing of the theta-activity and increased the power of the alpha-band. The role of 5 HT1A and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats was discussed.
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The influence of diazepam (1 and 5 mg/kg, i. p.) and buspirone (5 and 10 mg/kg) on the Fourier's spectral EEG power of sensomotor cortex and a conflict behavior in freely moving rats were studied. Diazepam (1 mg/kg) and buspirone (5 mg/kg) produced slowing of EEG theta-activity. Large doses of diazepam and buspirone produced different and multiple EEG effects. To 15-1788 (10 mg/kg) completely antagonized all the effects of diazepam (5 mg/kg). The authors discuss possible mutual relations between the influence on EEG and anxiolytic effect of these tranquilizers.
The influence of diazepam (1; 5; 10 mg/kg, i. p.), chlorpromazine (1 mg/kg) and amphetamine (1; 5 mg/kg) on the Fourier's spectral EEG power of sensomotor cortex and dorsal hippocampus and conflict behavior freely moving albino and cotton (Sigmondon hispidus) rats was studied. Effects of diazepam (5 mg/kg) in cotton rats were similar, but influence on the theta-activity was more expressed. Correlation between slowing of theta-activity and extent of anxiolytic effect in conflict situation was showed. On the basis of the results obtained the authors discuss possible mutual relations between the influence of diazepam on EEG and anxiolytic effect of benzodiazepines.
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The influence of some drugs (piracetam and 3-oxypyridine derivative) having a nootropic effect on ethanol-induced changes of bioelectrical activity was studied in experiments on freely moving rats. Discontinuation of ethanol administration (1, 2 g/kg, i.p. for 40 days) has been found to provoke destructuring of Fourier's spectral power of sensorimotor cortex and dorsal hippocamp on the EEG. Long-term administration of piracetam or 3-oxypyridine derivative (300 and 50 mg/kg, respectively, i.p. for 40 days) with ethanol has a protective effect and normalizes EEG at the cortical level. The authors discuss possible neurophysiological mechanisms of nootropic drug action in ethanol-induced pathology.
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The influence of brain acid extract products, isolated by high-performance liquid chromatography on H3-diazepam binding was investigated in synaptosomal membranes of C57BL/6 and BALB/c mice. Fractions with stimulatory and inhibitory activity were isolated. Quantitative and qualitative differences in the effects and structure of ACTH-immunoreactive peptide fractions under study were established.