Biomedical subjects

N N Dodge

Publications and source records attributed to N N Dodge.

6 recordsLinked to original sources

PubMed1995

Agenesis of the corpus callosum and Dandy-Walker malformation associated with hemimegalencephaly in the sebaceous nevus syndrome.

The sebaceous nevus syndrome is sometimes associated with hemimegalencephaly and a group of related abnormalities including ipsilateral gyral malformation, mental retardation, seizures, especially infantile spasms, and facial hemihypertrophy. This combination has been described as the "neurological variant of epidermal nevus syndrome." Other brain malformations have been reported only rarely. We report on a child with a subtle sebaceous nevus associated with hemimegalencephaly who also had agenesis of the corpus callosum and Dandy-Walker malformation.

Abnormalities, Multiple↗

PubMed1995

Managing patients who have seizure disorders: dental and medical issues.

Some dental professionals may have concerns about treating patients who have seizure disorders. The authors contend that increased knowledge about seizures and how to manage them may make dental professionals more comfortable. This article reviews the various seizure types, discusses commonly used anticonvulsants and their side effects and outlines some special concerns dentists may have in providing care to these patients.

Anticonvulsants↗

PubMedDate not supplied

Office management of the young child with cerebral palsy and difficulty in growing.

All infants and young children need adequate caloric intake for optimal growth and development. This is true for children with cerebral palsy, who are at increased risk for nutritional problems. When appropriate weight gain is difficult to attain, professionals must carefully evaluate the child's diet, feeding skills, and neurodevelopmental function; assess parenting behaviors; and look for complications of the child's cerebral palsy that could further impede intake and retention of calories. A number of therapeutic recommendations can be given to families to improve potential weight gain. The opportunity to influence the overall growth of young children with cerebral palsy begins when early and timely interventions are provided to the family.

Cerebral Palsy↗

PubMedDate not supplied

Persistent failure-to-thrive: a case study.

The inability to successfully feed a young infant or child is as worrisome to parents as it is to the health care provider. Early growth failures are likely to reflect difficulty with infant homeostasis and often respond to medical management of the physical problem that is temporarily interfering with the infant's ability to feed by mouth. In addition to medical management, however, treatment also necessitates investigation and management of behavioral problems that so universally accompany growth failure. This article presents a case study of a child who presented with poor growth and respiratory symptoms associated with nonregurgitant gastroesophageal reflux, a clinical entity that can be difficult to recognize. Although surgical management of this condition was successful, persistent failure-to-thrive continued and was seemingly recalcitrant to treatment. The use of cyproheptadine as an appetite stimulant to promote weight gain in this child is discussed with a review of the current literature regarding this pharmacologic approach to poor weight gain. A behavioral-based treatment plan is described as an alternate management method, avoiding the use of pharmacologic agents in general.

Cyproheptadine↗

PubMedDate not supplied

Neurodevelopmental outcome and respiratory morbidity for extracorporeal membrane oxygenation survivors at 1 year of age.

Outcome at 1 year was evaluated in 37 neonates treated with extracorporeal membrane oxygenation (ECMO) between June 1987 and March 1989. Thirty of 37 survived, and 7 of 30 showed major abnormalities in respiratory status, neurologic examination, or developmental status. Abnormal respiratory status was defined as need for supplemental oxygen, tracheostomy, or mechanical ventilation, and developmental delay was defined as developmental quotient < 70 on either the Mental or Psychomotor scale of the Bayley Scales of Infant Development. Five of seven children with major abnormalities were affected in more than one system. Adverse outcome was associated with the presence of congenital anomalies. Perinatal factors including Apgar scores, last pH before starting extracorporeal membrane oxygenation, and number of hours on ECMO did not show a significant correlation with Bayley scores. Computed tomography and electroencephalography of neonates showed no relationship to Bayley scores or neurologic examination. In conclusion, a small subgroup of patients accounts for the majority of abnormal findings at 1 year, and the presence of congenital anomalies appears to increase the risk for abnormal outcome.

Cohort Studies↗

PubMedDate not supplied

Outcome of extracorporeal membrane oxygenation survivors at age two years: relationship to status at one year.

The objective of this study was to assess the respiratory, neurologic, and developmental status at age 2 years of children treated with extracorporeal membrane oxygenation (ECMO) as neonates. The study population comprised patients treated at a tertiary care neonatal unit and included in a high-risk follow-up program. Eighty-five consecutive patients were treated with ECMO between June 1987 and October 1990, of which 64 (75%) survived. Forty-eight (73%) of the survivors underwent evaluation of growth and respiratory status, neurologic examination, and psychometric testing at ages 1 and 2 years. At age 2 years, 21% of study patients had at least one abnormal growth parameter (weight or length < 5%, head circumference < 2%). Twenty-one percent required respiratory medications and two children had tracheostomies. Six percent had significant abnormalities on neurologic examination. Twenty-five percent scored between 70 and 85 on the mental or psychomotor scales (or both) of the Bayley Scales of Infant Development or the Stanford-Binet, and 12% scored less than 70. Seventy-three percent of children who scored 70 to 85 on one or both subscales of the Bayley Scales of Infant Development or the Stanford-Binet at 2 years had normal scores at 1 year, as did 50% with scores less than 70. Spearman rank analysis suggested a relationship between congenital diaphragmatic hernia, neonatal electroencephalogram, and computed tomography of the head and developmental status at age 2 years (p < 0.05). We conclude that children treated with ECMO are at significant risk for abnormalities in growth and neurodevelopmental and respiratory status at age 2 years, which may not be evident at earlier assessments. This highlights the need for continued follow-up.

Central Nervous System↗