Biomedical subjects
Publications and source records attributed to N N Grigor'eva.
The authors substantiate morphologically the protector effect of K(2)9 enterosorbent during its parallel use with the antitumour anthracyclin antibiotic carminomycin. The agent was administered intraperitoneally in animals at the maximum tolerable dose. Use of the K(2)9 enterosorbent reduces the cardiotoxic effect of carminomycin.
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Morphological methods helped to establish optimal conditions of storing venous autotransplants and their preparation to transplantation before the operation of aortocoronary shunting.
Regularities of structural changes and pathogenesis of pathological processes in the myocardium in intermediate form of ischemic heart disease indicates the necessity instituting adequate pathogenetic treatment and prophylaxis of hypertensive conditions, normalization of the coronary blood circulation, increase of the resistance of the myocardium to hypoxia, strengthening of reparative processes in the myocardium, activation of oxidation-reduction processes.
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It was established by histochemical and immunomorphological investigations that acute myocardial infarction results in an activation of the immune system of the body, immunomorphological changes in the lungs that plays a certain role in the pathogenesis of pneumonias in ischemic heart disease.
Mutagenic effect of direct electric current on sprouts of Vicia faba L. was detected. The effect manifested itself in increase in percentage of cells with chromosome aberrations in root meristem. The most considerable injuries are observed when root meristem contacts with the positive electrode during current passing. Typical peculiarity of mutagenic effect of current is appearance of dicentrics which exceed the control value 4 times. By the end of the first mitotic cycle, gradual reduction of percentage of injured cells, reaching the control value, is observed.
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Effects of high sub-lethal temperature and UV-irradiation on surviving of inbred lines of Drosophila melanogaster and its F1 hybrids derived from reciprocal crosses between these lines are investigated. High resistance of F1 hybrids to these factors was observed as compared with that of parental inbred lines. D. melanogaster females in inbred lines and F1 hybrids were more resistant than males. Differences in the resistance between females and males were more pronounced in hybrids.
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