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Biomedical subjects

N N Gritsman

Publications and source records attributed to N N Gritsman.

11 recordsLinked to original sources
PubMed1978

[Formation and destruction of the skin collagen structures in systemic scleroderma].

Histological, electron microscopic, and morphometric studies of skin biopsies from 70 patients with systemic sclerodermia showed an increase in biosynthetic processes both in the affected and nonaffected parts of the skin. Enhanced neofibrillogenesis was found only in areas of sclerodermic lesions. Abnormalities in newly formed collagen structures as well as splitting of newly formed collagen fibrillae into microfibrillae were observed. In unaffected skin areas two types of destruction of collagen fibrillae were observed: extracellular destruction and fibroplasia.

Adolescent↗
PubMed1977

[Study of an articular cartilage in rheumatoid arthritis by the immunofluorescence method].

The immunomorphological examinations of 20 biopsy specimens of articular cartilage in rheumatoid arthritis at various stages of the pathological process showed immunoglobulins of different classes and complement (C'3) to penetrate into the articular cartilage. In early stages mostly IgG was detected, and with increasing destructive processes in the matrix IgM was found. A certain tropism in the distribution of immunoglobulins in the cartilage matrix to the zones of chondrocytic capsules was observed which could be associated with the direction of immune reactions towards chondrocytes. The articular cartilage tissue may be the basis for the development of the autoimmune process and maintain permanent inflammatory process in the synovial membrane of the joint with local antibody synthesis. The process of phagocytosis of the antigenic substances of the articular cartilage or immune complexes deposed in it underlies the distribution of pannus.

Arthritis, Rheumatoid↗
PubMed1976

[Interstitial microfibrils in the myocardium in rheumatic and congenital heart defects].

Electron-microscopic and electron-histochemical studies of biopsies of the myocardium from the patients suffering from rheumatic and congenital affections of the heart showed that hyperplasia of aperiodic argyrophilic and ruteniophilic microfibrillae served as the ultrastructural equivalent of coarsening of the reticular frame of the hypertrophic myocardium. Relapse of the rheumatic process is accompanied by irregulation and possibly by an increase in the number of microfibrillae due to their accelerated neoformation and defibrillation of the collagen fibrils with a periodicity of 640 A. There was traced no direct relationship between the amount of microfibrillar material on the surface of the muscle cells and the extent of destruction of their organellae; this, however, did not exclude the possible interrelation between the myocardial insufficiency and hyperplasia of the myofibrillae as an integral component of fibrosis and sclerosis of the myocardium.

Basement Membrane↗
PubMed1975

[Acid polysaccharides (glycosaminoglycans) of the articular cartilage in rheumatoid arthritis].

As a result of histochemical investigation of the articular hyaline cartilage in 22 pateints with rheumatoid arthritis data were obtained on the decrease and redistribution of acid polysaccharides glycosamine glucane including keratosulphates, which led to an impartment of the cartilage supply and development therein of destructive processes. It was established that the most pronounced changer occurred in the main substance of the cartilage; changes in chondrocytes, according to the authors, were of secondary nature.

Adolescent↗
PubMed1975

[Morphologic changes in the chorio-allantoic membrane and organs of chick embryos inoculated with blood of patients with systemic lupus erythematosus (concerning the viral etiology of systemic lupus erythematosus)].

Morphological studies of 14 chorionallantoic membranes and organs of chick embryos which had been infected on the 7--8th day of incubation with leucocytic mass from patients with systemic lupus erythematosus were carried out. Corresponding virological and morphological control studies were performed. The changes observed were repeatedly reproduced in multiple inoculations (from the 2nd to the 16th passage). Apart from morphological changes, which may be listed among general pathological processes (impairment of the circulation, dystrophy, proliferation), changes testifying to a possible cytopathic effect disintegration of nuclei, formation of gigantic cells and multinuclear symplasts were also noted. The most pronounced changes, both in the chorionallantoic membrane and in internal organs, were observed on the 3rd--5th passage and on the 3rd--5th day of incubation following inoculation. They correlated with the clinical activity of the process in patients from whom the blood for inoculation had been taken. The data obtained justify the assumption concerning the existence in the blood of the patients with systemic lupus erythematosus a transplantable agent producing a cytopathic action, and may be considered as a new indirect corroborative evidence in favour of the concept of the viral nature of systemic lupus erythematosus.

Animals↗