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Biomedical subjects

N N Gupta

Publications and source records attributed to N N Gupta.

At least 19 recordsLinked to original sources
PubMed1978

3-Methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in urine of humans with hypertension.

3-Methoxy-4-hydroxyphenylglycol (MHPG) was measured in lumbar spinal fluid of 20 subjects with hypertension of varied etiology and severity. There was a significant correlation between the concentration of MHPG and the severity of hypertension. However, changes in the concentration of vanillylmandelic acid in the urine of these subjects were insignificant. In six subjects, administration of clonidine or alpha-methyldopa, two centrally acting antihypertensive drugs, was associated with a significant lowering of MHPG concentrations. These data support the hypothesis that central catecholamines are involved in clinical hypertension.

Blood Pressure↗
PubMed1978

T lymphocytes and anticardiac antibodies in patients with ischemic heart diseases.

85 patients with a variety of ischemic heart diseases were examined for the proportion of T cells and the presence of anticardiac antibodies. Patients with acute myocardial infarction during the 2nd and 3rd week of initial acute episode had a higher proportion of T lymphocytes and a higher proportion of patients developed anticardiac antibody. Similar was the case with patients with angina. The extent of infarction and accompanying complications did not change the immune parameters studied. The relationship of anticardiac antibodies and T lymphocytes in context of ischemic heart diseases is discussed.

Acute Disease↗
PubMed1976

A double-blind trial of penbutolol: a new beta-receptor blocking agent in the treatment of angina pectoris.

A double-blind placebo controlled study of angina pectoris with penbutolol was undertaken in parallel groups in fifty-two patients. The duration of the study was six weeks. The dosage range for penbutolol was 8 mg to 50 mg per day. Six patients were dropped from the analysis. Seventeen patients (81%) in the penbutolol series exhibited a 50% reduction in anginal attacks, NTG consumption and subjective improvement. Significant reduction in nitrite intake was observed. Effort tolerance was improved significantly in those receiving penbutolol. Penbutolol was well-tolerated.

Adrenergic beta-Antagonists↗