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Biomedical subjects

N N Konstantinova

Publications and source records attributed to N N Konstantinova.

At least 19 recordsLinked to original sources
PubMed2005

Fluorescent microscopic study of epithalon binding in maternal and fetal rabbit tissues in health and under conditions of placental insufficiency.

Epithalon (regulatory tetrapeptide) labeled with dansil (fluorescent stain) easily penetrates into all tissues and organs of pregnant rabbit females and through the placenta into fetal organs. Incorporation of labeled epithalon in placental tissues is more often observed in fetuses developing under conditions of placental insufficiency than in normal fetuses.

Animals↗
PubMed2002

[Adaptive thermoregulatory reactions of the rabbit fetus at the end of the intrauterine development].

The data of permanent simultaneous registration of electrocardiogram, rectal & brown adipose tissue temperatures of the rabbit foetus have been obtained in chronic experiments. The haemodynamic shift in intensity of maternal-placental and foeto-placental blood flow (by female trental injection) led to a decrease in the foetus rectal temperature (0.33 +/- 0.09 degree C in intact foetus and 0.58 +/- 0.27 degree C in retarded foetus, p < 0.05). Both foetuses reacted by rectal temperature decrease (0.65 +/- 0.28 & 0.68 +/- 0.31 degree C, respectively) during immobilisation (by foetus arduan injection). Thus in both series of experimental cooling of foetus, brown fat activation was similar in intact foetus (approximately 53%), but did not change in growth retardation foetus--as a result of its tissue functional immaturity, probably.

Adaptation, Physiological↗
PubMed1999

Functional and biochemical criteria for investigation of brain development disorders.

Functional state and creatine kinase (CK) activity in the amniotic fluid and blood of anencephalic fetuses was studied in the second trimester of pregnancy with the following pathomorphological investigation of the state of their CNS to reveal possible markers of development disorders. The extent of neurological disorders in newborn infants was retrospectively compared with data from functional studies of components of a biophysical profile (motor-cardiac reflex, heart rhythm oscillations, respiratory movements) and with CK activity in the amniotic fluid and blood of fetuses with hemolytic disease and fetuses of diabetic mothers and normal mothers in the third trimester of pregnancy. The results revealed informative indices of fetal CNS developmental disorders in the prenatal period that are of importance for predicting a prognosis of the extent of neurological disorders in newborn infants. These results will allow the establishment of criteria for evaluation of fetuses to reveal possible disorders in the formation of the CNS.

Amniocentesis↗
PubMed1996

[Morphophysiological analysis of the formation of mechanisms of the activity-rest cycle in human ontogenesis].

The natural behavior of normal and anencephalic fetuses at 20 to 41 weeks of the development was studied by ultrasound monitoring and continuous recording of heart rate (HR) and motor activity (MA), followed by processing and presentation on [symbol: see text]CM computer. The statistical characteristics of HR and MA changes in the anencephalic fetuses were corrected by the degree of CNS deficiency. The comparative study of 20 normal and 34 anencephalic fetuses showed: 1) when the spinal cord was present, stable HR (about 150 bpm) seems to be due to cardiac automatism and sharp decelerations unaccompanied by MA were recorded; 2) in fetuses with the medulla oblongata present showed a decrease in baseline HR up to 140 bpm, repeated pronounced decelerations and spontaneous single motor acts dissociated with the latter; 3) when a rudiment of the midbrain was present, some reductions in the amplitude of decelerations and manifestation of weak accelerations, cluster motor acts, brief episodes of the active state were revealed; 4) the quiet state was observed in fetuses with the cerebral cortex; 5) the rest-activity cycle formed with further differentiation of the cerebral cortex.

Anencephaly↗
PubMed1990

[Intrauterine blood transfusion as a method of treatment of the edematous form of hemolytic disease of newborn].

Results are reported with intrauterine donor blood transfusions in 7 fetuses with hydropic hemolytic disease. Eight intraabdominal and 8 intravascular sonographically guided fetal transfusions were given at 25-30 weeks' gestation with fetal heart rate monitoring. The criteria for efficacy were disappearance of ascites, reduction in fetal hepatic and splenic sizes, thinning of the placenta. Three fetuses died in utero from symptomatic hydropic hemolytic disease despite the therapy. Four other fetuses were delivered at 30-34 gestational weeks by cesarean section and showed no abdominal ascites. One of the fetuses died from birth trauma on the second postnatal day while the other three were discharged in a satisfactory condition.

Blood Transfusion, Intrauterine↗
PubMed1989

[Pathogenesis of fetal growth retardation and behavioral disorders in the progeny caused by smoking during pregnancy].

A review of data reported in the literature and those obtained by the authors on disorders of fetal development in smoking pregnant women, the significance of disturbed maternal adaptation to pregnancy, and maternal, fetal and placental effects of nicotine, carbon dioxide and other constituents of tobacco smoke is presented. The genesis and damaging effect of hypoxia on fetal brain, eventually resulting in mental retardation, are discussed.

Child Behavior Disorders↗
PubMed1985

[Status and reaction to anoxia of rat fetuses developing in conditions of placental insufficiency].

Significant adverse correlation of the fetus mass and the degree of its hydration was noted at term in rats with placental insufficiency induced by ligation of about 40% of preplacental vessels on the 16th day of gestation. Disorders revealed in transplacental water-salt metabolism are apparently of some importance for the pathogenesis of fetal growth retardation. Even moderate retardation alters fetal respiratory activity in anoxia, which is associated with the changes in the function of respiratory centres and neuromuscular abnormalities.

Animals↗
PubMed1980

[Protein synthesis in different rabbit embryo tissues in the presence of utero-placental ischemia].

Resistance of different elements of the hemodynamic functional "mother--placenta--fetus" system to the damaging effect (ligation of a half of preplacental vessels, performed on the 8th day of pregnancy) was studied and compared in experiments on female rabbits on the 12th day of pregnancy. It appeared that under these conditions the extent of growth retardation in different embryonic and placental structures is dissimilar. The processes of cytoplasmic protein synthesis in heart tissues are more resistant to the damaging effect than in bodily tissues. The delayed hemoglobin accumulation in the embryonic organism was not so pronounced as retardation of protein synthesis in the body.

Animals↗