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N N Mamaev

Publications and source records attributed to N N Mamaev.

42 records · Page 3Linked to original sources
PubMedDate not supplied

[Results of the study of the activity of bone marrow nucleolar organizers in patients with multiple myeloma].

Data obtained from karyotyping and estimation of nucleolar organizer (NO) activity in bone marrow cells from 9 patients with multiple myeloma (MM) and from 8 donors are presented. Chromosomes of the 14th and 1st pairs in patients with MM are confirmed to be more frequently involved in rearrangements. It is proved that activity of NO in myeloma cells is rather high as compared to that of erythroid and granulocyte cells, that is associated with their participation in paraprotein synthesis.

Aged↗
PubMedDate not supplied

[An evaluation of the plastic function of the cardiomyocytes by silver staining of the nucleoli in patients operated on for ischemic heart disease].

Examinations of plastic function changes in myocardial cells (MC) from 36 patients with chronic ischemic heart disease were carried out before, during and soon after cardioplegic ischemia. The initial mean number of silver grains in nucleoli varied greatly showing some difference between groups of the patients with (9.5 +/- 0.48) or without (11.0 +/- 0.5) myocardial infarction. During the myocardial arrest this index of MC plastic activity was decreased in all but 7 patients. In contrast to this, it was elevated in most patients tested during subsequent reperfusion. On the basis of these data and parallel histochemical photometric assessment of DNA, RNA and succinate dehydrogenase activity, a hypothesis was suggested which explains the non-standard elevation of ribosomal cistron activity during both myocardial arrest and reperfusion by their compensatory reaction to myocardial injury.

Angina Pectoris↗
PubMedDate not supplied

[Functional activity of human thyrocytes in diffuse toxic goiter, autoimmune thyroiditis and thyroid nodules using nucleolar silver staining].

A comparative study of the thyrocyte nucleolar organizer region (NOR) activity was performed on silver - stained thyroid gland aspiration biopsies from controls, 39 patients with Graves' disease (GD), 15 other patients with Hashimoto thyroiditis (HT), and 71 patients with nodules which underwent surgery. Thyrocyte nucleoli from unchanged thyroid gland were round and small-sized. Their number ranged from 1.34 up to 1.96 per nucleus (mean 1.61 +/- 0.07). The average number of silver (Ag) grains ranged from 3.0 to 6.9 per nucleus (mean - 5.36 +/- 0.36). Compared to the controls the patients with GD revealed thyrocyte nucleoli with increased mean number of AG - grains per nucleus (9.84 +/- 0.24). There was a close correlation between thyrocyte NOR activity, on the one hand, and the level of T3 or T4 hormones and thyroid gland size, on the other. In patients with AT the argentophilla of thyrocyte nucleoli was intermediate between that of controls and patients with GD. This group of patients revealed an increased NOR activity of thyroid gland lymphocytes. Nucleoli of malignant thyroid cells were larger and more irregular than those of benign cells. The mean number of malignant cell nucleoli (2.55 +/- 0.22) was greater than that of the control group (1.61 +/- 0.07; p < 0.05) being identical with those of follicular adenomas (2.47 +/- 0.11) and nodular goiter (2.46 +/- 0.11). The mean number of Ag-grains in the malignant cells (14.9 +/- 0.79) was higher than that in FA (7.95 +/- 0.2; p < 0.0001) and NG (8.0 +/- 0.12; p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Prognostic significance of the activity of nucleolar organizer regions in megakaryocytes from patients with acute lymphoblastic leukemia].

Bone marrow films from 20 patients with acute lymphoblastic leukemia (ALL) and 40 patients with acute nonlymphoblastic leukemia (ANLL) were investigated using Ag-NOR staining. The control group comprised 12 donors. The activity of nucleolar organizer regions (NOR) in the whole population of megakaryocytes (MK) and in groups of MK with 1-3, 4-6, 7 and more lobules per nucleus was assessed. The division into groups made it possible to judge about NOR activity in MK with different ploidy. The MK with both high ploidy and high NOR activity in residual megakaryocytopoiesis in patients with ALL are associated with good response to chemotherapy and complete remission, whereas these with low ploidy and low NOR activity suggest poor prognosis. In patients with ANLL no stable correlation between NOR activity and prognosis was found.

Case-Control Studies↗