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Biomedical subjects

N N Mertsalova

Publications and source records attributed to N N Mertsalova.

4 recordsLinked to original sources
PubMed1981

[Functional activity of thrombocytes soon after implantation of an artificial heart].

Experiments on calves undergoing implantation of artificial hearts (Soviet models) under extracorporeal circulation were made to examine platelet adhesion and aggregation. It was demonstrated that the increase in platelet adhesion and aggregation set in from the 2nd hour of the artificial heart work and lasted till the end of the experiments. It was discovered that platelet aggregation correlated well with fibrinogen concentration.

Animals↗
PubMed1978

[Interrelationship between contact coagulation, surface charge and roughness].

The negative surface charge and the mechanically even surface were found in vitro to hinder the blood hypercoagulation, fibrin absorption, and thrombocytes hyperadhesion. The surface negative electrical charge of 6--10(-9)Cl/cm2 and the surface of the 9--14th class of mechanical evenness seem to be optimal for prophylaxis of thrombosis at the blood-surface border. The surface negative electrical charge reduces the possibility of thrombosis on mechanically rough surface.

Biophysical Phenomena↗
PubMedDate not supplied

[Effect of surface roughness of polymers on thrombus formation].

Thromboresistant properties of fluoroplast-4, lavsan, polymethylmetacrylate, carbon glass, employed in various devices contacting the blood and presenting different degrees of the surface roughness, were studied. The thromboresistant properties of polymers were judged on the ground of modified methods for determining the blood coagulating time, thromboelastograms, with reference to the prothrombin complex factors concentration, the amount of fibrinogen, heparin blood tolerance, the thrombocytes adhesion index, their splitting and flattening. A higher class of the polymer surface roughness was found to raise the thromboresistant properties of the surface. In case of polymers with high mechanical and strength properties the surface roughness is of greater importance in the genesis of thrombosis than in polymers possessing elastic properties.

Biocompatible Materials↗