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Biomedical subjects

N N Prozorovskaia

Publications and source records attributed to N N Prozorovskaia.

At least 19 recordsLinked to original sources
PubMed2003

[Antioxidant activity of flaxseed oil].

Effective concentration of antioxidants and its reactivity toward peroxil radicals (constant k7) have been measured by the chemiluminescence technique for flaxseed oil. Effective concentration of antioxidants is shown to depend on the technology of producing flaxseed oil; period of seed storage before use; and storing duration of flaxseed oil also. Minor component content of flaxseed oil, which may be the members of antioxidant pool, has been quantitatively estimated.

Antioxidants↗
PubMed1991

[Age changes in the level of pyridinoline cross-linking and ratio of soluble and insoluble collagen in human rib collagen].

The changes in the content of mature crosslinks with pyridinoline structure and soluble/insoluble collagen ratio in the costal cartilage tissue of human beings aged from 1 month to 57 years were found to be age-dependent. The effect of the pyridinoline crosslink content on the soluble/insoluble collagen ratio in human costal cartilage tissue may constitute no less than 67% of the total influence of the sum of all factors. The pronounced nonlinearity of the studied dependencies points to a possible involvement of a factor(s) other than the pyridinoline crosslink content.

Adult↗
PubMed1990

[Early diagnosis of progression of funnel chest in children].

104 patients with progressive forms of funnel chest deformity of the II-III degree with Ehlers-Danlos-Marfan syndrome, Marfan-like phenotype, isolated funnel chest deformity and unclassified funnel chest deformity of the first degree were subjected to synromologic examination. There were detected 10 dysplastic signs, indicating funnel chest deformity progression: anti-Mongol shape of the eyes, arachnodactyly, high palate, Ehlers-Danlos syndrome, floor of the auricle's dysplasia, dolichostenomely, posture disturbance, mitral valve prolapse, umbilical hernia, wide filter. The results of biochemical examination of collagen metabolite--hydroxyproline++ (the first and the second hydroxyproline++ fraction ratio disturbance, decrease of the first hydroxyproline++ fraction percentage, disturbance of direct correlation between total hydroxyproline++ and percentage of the first hydroxyproline++ fraction)--corroborated the clinical data.

Adolescent↗
PubMed1980

[Tissue enzymatic study in the perfusate of cadaveric kidneys for assessing their functional state].

A correlation was found between the level of the tissue enzyme activity in cadaveric kidneys perfusates and the degree of their functional adequacy in the early posttransplantation period. According to the data obtained the level of the activity of leucin aminopeptidase and gamma-glutamyltranspeptidase in the perfusates may be of importance for prognostication of a delayed function of the kidneys after transplantation. An elevated level of activity, in addition to leucin adminopeptidase and gamma-glutamyltranspeptidase, lactatedehydrogenase, aspartataminotransferase, muramidase, acid and alkali phosphatases suggests the transplanted kidney to be not functioning.

Adult↗
PubMed1975

[DNA and antibodies to DNA in Aleutian mink disease].

Free DNA and various types of antibodies to DNA were determined in the blood serum and plasma of minks which contracted Aleutian disease (AD) spontaneously and of minks experimentally infected with this disease. Healthy minks and other animals served as controls. It was found that a higher incidence of antibodies to DNA of the 2nd and 3rd types in high titres (1: 80-1: 2560) was characteristic of the experimental group of animals. Besides, a free polymeric DNA was more frequently revealed in the experimental group of animals.

Aleutian Mink Disease↗
PubMed1975

[Homogenate factor of minks with Aleutian disease].

Antibodies to the factor present in the homogenate of the organs of minks experimentally infected with aleutian disease (AD) were revealed in the sera of minks with AD and also in the sera of humans suffering from systemic lupus erythematosus, hepatitis and cirrhosis, scleroderma and dermatomyositis. Sera of sick minks and humans failed to interact with control homogenates of the organs of healthy minks. In turn, sera of practically healthy minks and humans did not react with the AD-homogenate.

Aleutian Mink Disease↗
PubMedDate not supplied

[Antioxidant properties of a leaf extract from Aronia (Aronia melanocarba) containing proanthocyanidins].

Antioxidant capacity of a procyanidin-containing extract from Aronia melanocarpa leaves has been studied in vitro and in vivo. Using the chemiluminescence technique, the effective content of antioxidants and its reactivity towards peroxyl radicals have been measured in a model reaction of initiated oxidation of hydrocarbon for the whole extract and two of its chromatographic fractions separated by HPLC. The results indicate that the extract contains a combination of antioxidants with different radical scavenging activities. The value of the rate constant of the reaction with peroxyl radicals (constant k7) for the extract strong inhibitors is of the same order of that for alpha-tocopherol and its synthetic analog chroman C. A decrease in antiradical activity directly related to the high concentrations of this extract in reactive mixture has been observed. This extract significantly reduced in dose-dependent fashion the CCl4-induced hepatic lipid peroxidation. The extract also inhibited flaxseed oil peroxidation. The present study indicates significant antioxidant capacity of the extract from Aronia melanocarpa leaves.

Antioxidants↗
PubMedDate not supplied

[Biological activity of linseed oil as the source of omega-3 alpha-linolenic acid].

Flaxseed oil is the most abundant plant source of omega-3 fatty acid, alpha-linolenic acid omega-3. This review focuses on the biological effects of dietary alpha-linolenic acid (ALA) compared with long-chain omega-3 derivatives. ALA is not equivalent in its biological effects to the long-chain omega-3 fatty acids found in marine fish oils. However, ALA is metabolized to eicosapentaenoic acid, which may replace arachidonic acid in membrane phospholipides. Ingestion of flaxseed oil may alter the generation of eicosanoids, procoagulant activity and other membrane-dependent responses and exert antiallergic, antiatherosclerotic, antiarrhythmic effects. Beneficial effects of flaxseed oil have been shown in prevention and management of cardiovascular disease.

Animals↗
PubMedDate not supplied

[Biological effects of the soybean phospholipids].

Soyabean phospholipids, particularly commercial lecithin, are now widely used as biological active food additives. Mechanisms of their activities are based mainly on their similarity with ow phospholipids of biomembranes and blood lipoproteins. The similarity allows the inclusion of plant phospholipids into these structures and promotes prevention of number of pathological processes. Soybean phospholipids have a wide range of biochemical and physical effects. Lecithin complex is the source of easily accessible linoleic acid, choline and inositol. Lecithin plays a notable role as synergist for antioxidants also. The proven health benefits which can be achieved by taking soybean phospholipids include lipid-lowering; control of blood levels of cholesterol and triglyceride, stabilisation of the membrane functions, supporting the hepatic functions. Structure, some physico-chemical properties and metabolism of phospholipids, and molecular mechanisms of their prophylactic effects are briefly reviewed.

Cholesterol↗
PubMedDate not supplied

[Excretion of pyridinoline with urine in children with Ehlers-Danlos syndrome and Marfan's syndrome and the effect of beta blocker and complex vitamin therapy on it].

Excretion of pyridinoline and polypeptide-bound hydroxyproline with urine was studied in 27 children with hereditary impairment of connective tissue. At the same time, effects of beta-adrenoblocking agents and vitamin complex, prescribed during preoperation period before thoracoplasty in hereditary chest deformation, were investigated. Clinical efficiency of the treatment depended distinctly on the initial value of ratios pyridinoline/creatinine and polypeptide-bound hydroxyproline/creatinine. Total positive effect of the therapeutic course, considering also echocardiographic examination and postoperational complications, was observed in 44% of patients with Ehlers-Dunlop syndrome and in 75% of patients with Marfan syndrome.

Adolescent↗
PubMedDate not supplied

[Physiological changes in pyridinoline excretion in urine depending on age and sex].

Natural physiological alterations in excretion of pyridoline (total hydroxypyridoline and lysyl pyridoline) with urine were studied in children and adults depending on age (1-86 years old) and sex. Age-dependent alterations of pyridoline excretion with urine had apparently four phases: an increase, a decrease, stabilization and secondary increase. Distinct dissimilarity between men and women in the rate of pyridoline excretion was found only in the age group of 16-21 years old.

Adolescent↗
PubMedDate not supplied

[The connection between the decomposition of mature collagen and the level of natural cytotoxicity in patients with focal scleroderma].

Increased rate of pyridinoline excretion with urine was detected in patients with focal sclerodermia: the ratio pyridinoline/creatinine was equal to 0.094 +/- 0.049 as compared with that of 0.073 +/- 0.049 in controls. Concentration of mature collagen cross-links involving pyridinoline structure in urine of patients with focal sclerodermia did not depend on the patients age and the disease duration. However, this pattern correlated distinctly with clinical form of the disease (0.073 +/- 0.049 in local form and 0.013 +/- 0.017 in generalized form of sclerodermia) as well as correlated reversely with the rate of activity of natural killer cells (r = -0.977).

Adult↗