PubMed Health⌕ Search

Biomedical subjects

N N Shuĭkin

Publications and source records attributed to N N Shuĭkin.

At least 19 recordsLinked to original sources
PubMed2005

[The behaviour and respiration features in rabbits with different pattern of their open field locomotor activity].

Behavior of 19 Chinchilla rabbits was tested in the open field. By the results of the first trial, animals were divided into three groups by the type of the exploratory locomotor activity (passive--37%; active--21; and medium--42%). During the repeated open field trials, the passive rabbits increased their activity and the active ones decreased it. Correlations were found between the open field behavior and patterns of the external respiration in the absence of movements. The longest respiratory cycles, expirations and respiratory breath holdings were observed in passive rabbits. Animals with prevailing right turnings in the open field displayed longer respiratory cycles and expirations than those with prevailing left turnings. It seems that the pattern of external respiration can predict the passive defensive strategy of rabbits in negative emotional situations.

Animals↗
PubMedDate not supplied

[The correction of the manifestations of a neurosis-like state in white rats by using the vitamin complex Aekol].

Behavior of neurotized white rats was studied in two experimental situations: during training for passive and active avoidance of electroshock applied to the limbs and during testing the acquisition of the conditioned avoidance. It was shown that in behavior of rats in the neurosis-like state the signs of anxiety and fear dominated, the orienting-exploratory behavior was suppressed. The state correction was performed by per os introduction of the natural vitamin complex Aekol during the neurotization of animals.

Animals↗
PubMedDate not supplied

[Correction by succinic acid of behavioral and physiological parameters of neurosis-like condition in white rats].

The neurosis-like state of white rats is accompanied by development of cerebral hypoxia. Negative symptoms of the neurosis-like state (behavioral, anatomic and energy) were decreased by per os administration of succinate (30 mg/kg) during the second half of the neurotization process. Succinate provided chiefly the delayed action on the system arterial tension, on the succinate dehydrogenase and NADH dehydrogenase activity. The effects depended on the propensity of a rat to the catatonic "freezing". The "freezing" was detected by a specific breathing pattern: a short inhale and a long pause. In "freezing" rats succinate corrected the system tension to a greater extent, while in "non-freezing" animals it corrected to a greater extent the succinate and NADH dehydrogenase activities. The positive effect of succinate administration is probably associated with its antihypoxic properties.

Animals↗
PubMedDate not supplied

[Peculiarities of exploration behavior of socially deprived rats in stress situation].

Male Wistar rats (n = 18) were studied at the age of 120 days after social deprivation in the period from the 22nd to 70th days of postnatal development. They displayed significant lower activity in the open field, elevated plus-maze, and Porsolt test than control animals (n = 19). Decreased exploratory activity was found to be related with higher level of anxiety. This was confirmed by their avoidance of open arms of the elevated plusmaze and reactions to approaching hand. These animals had problems in the maze arm choice. They showed low time variability of choice-related actions (waiting in the center of the open field or elevated plus-maze and change in the movement direction along an open-field wall, including the movement per se, and arm choice and changing, i.e., alternative choice). Shorter time of choice-related actions was observed in situations of unequal alternatives.

Animals↗
PubMedDate not supplied

[Features of rat behavior associated with alternative choice in Y-maze and their interpretation in terms of complex probability amplitudes].

The two-way alternative avoidance of a weak electric shock by male Wistar rats in Y-maze was studied. The following behavioral characteristics of a rat were determined in each test series: total time of an arm choice (going away into one of two safe maze arms), number and sequence of alternate turnings to the outlets in the process of choice, time of immobility in the Y-maze center, and "freezing" reaction. Rat behavior of choice of safe arms in Y-maze be interpreted on the basis of the rules of summation of complex probability amplitudes, which characterize a predictive estimation of achievement by a rat of its relative safety. With the need to avoid an electric shock, rat's estimations of suitabilities of two different avoidance ways can interfere. This makes it difficult for an animal to take a choice decision (if both pathways are equally acceptable for a rat). After entering a safe arm, sometimes a rat can leave it for another arm, such passages occur quasiperiodically.

Animals↗
PubMedDate not supplied

[Rat behavior in a light/dark chamber: place preference task].

After a 6-week social isolation (from 22nd to 70th day from birth) male Wistar rats (a sibship, 10 animals), were tested for 20 min in a light/dark box in order to reveal behavioral features of choice of their spatial localization in unknown conditions. Socially deprived rats significantly differed from control animals in longer time of the room choice, higher number of entries of the light section, and higher number of rearings, which was probably explained by their higher anxiety and lack of experience to estimate unexpected stimuli and select a response. The mean level of behavioral activity during exploration of the box defined by the number of elementary operations per minute remained constant and was significantly higher in the socially deprived rats than in the control animals.

Animals↗
PubMedDate not supplied

[Breathing patterns peculiarities as the index of the "animal hypnosis" state in the rabbit].

Breathing patterns were recorded during "animal hypnosis" in seven Chinchilla rabbits. The state of "animal hypnosis" was evoked by the hand pressure on the thorax and the waist of a rabbit. Breathing pattern was recorded by means of an elastic coal-powder element that was set round the rabbit's thorax. Distortions of the breathing patterns in the active state and in the course of hypnosis development were marked by numbers 0, 1, 2. In all rabbits, modifications of the breathing patterns depended on the features of the animal state: quiet state, tension, and "animal hypnosis".

Animals↗
PubMedDate not supplied

[Avoidance conditioning and morphometric characteristics of the sensorimotor cortex of rats exposed to social deprivation in early ontogeny].

Male Wistar rats were exposed to social deprivation in the period from the 22nd to 70th days of postnatal development. The characteristics of the learning of these rats at the age 110-120 days in the passive avoidance box and during training for active avoidance of electroshock were significant lower than those of control animals. Features of motor activities of the "isolants" in learning and testing, and in the "open field" may be related to their higher anxiety level. Morfometric studies of neurons and glial cells and neocortex thickness showed that significantly lower density of neural elements may be the result of the afferent sensory input limitation produced by the social deprivation.

Animals↗
PubMedDate not supplied

[Influence of emotional stimuli on behavior and respiration of rabbits with various locomotor activity in the "open field"].

Different behavioral reactivity of rabbit groups differentiated by locomotor activity in the "open field" was revealed during exposure to emotional stimuli (rustle, loud sound, pressuring on back of the neck, vibroacoustic tactile stimulation of an ear). In passive rabbits, the active locomotor reactions were induced harder and freezing was obtained easier than in active animals. During exposure to sound stimuli, passive rabbits increased their locomotion more rarely than active animals, pressing on back of the neck produced longer freezing, a threshold of defensive ear shaking in response to a vibroacoustic stimulus in passive animals was highest. Training to mild immobilization increased the threshold of defensive responses in active rabbits and animals of the intermediate type. Changes in respiratory parameters were correlated with behavioral reactions to emotional stimuli. The duration of exhalation and respiratory cycle increased during freezing and increased during enhanced locomotion. The duration of inhalation decreased in response to emotional stimuli irrespective of a behavioral reaction. The respiratory reactions to emotional stimuli differed in rabbits of different groups. The respiratory rate more frequently changed in passive rabbits than in animals of other groups. Passive animals reacted mainly by exhalation, active rabbits and animals from the intermediate group predominantly responded by inhalation.

Animals↗
PubMedDate not supplied

[Temporal sequence of SWD emergence and spontaneous jerks in WAG/Rij rats with absence epilepsy].

In rat model of absence epilepsy, abnormal complex movements of cervicothorathic part (jerks) were observed in the state of passive wakefulness. When a desynchronized low-amplitude electrical activity was recorded in the parietal and visual cortex, either SWD or jerks were observed. The SWD appearance prevented a jerk. If the discharge appeared between jerks, the interval between jerks increased. Particularly important is the fact that after subtraction of the discharge duration, the distribution of intervals between jerks became the same as in the absence of the SWD. This finding shows that an SWD just interrupts the development of a jerk. That is, when the discharge is over, the jerk develops from the level at which it was stopped by the discharge rather than from the initial level of excitation.

Action Potentials↗
PubMedDate not supplied

[External respiration as an index of the individual physiological characteristics of higher nervous activity in rats].

A special type of external breathing (stressed breathing) of rats has been described which develops spontaneously or is induced by an external factor. This type of behaviour is accompanied by a catatonic "freezing". Rats with stressed breathing significantly differ from those in the normal state in lower open-field activity and rate of the local volume blood flow in the hippocampus and motor cortex. The possibility is discussed of correlation of this type of breathing with the catatonia-like state.

Animals↗
PubMedDate not supplied

[The behavioral characteristics of rats induced by partial degeneration of the hippocampal cholinergic neurons].

The effects of intraventricular administration of ethylcholine aziridinium ion (AF64A) were studied in male Wistar rats. Bilateral injections of AF64A (3 nm/3 mcl) reduced the reactions to biological alarm signal and produced a decrease in the open-field activity 3 weeks after this lesion. The lesioned rats also displayed deficit in retention of a passive avoidance task.

Animals↗
PubMedDate not supplied

[The action of the neurotoxin AF64A on the reactions of neuroticized rats].

The effects of intracerebroventricular administration of ethylholine aziridinum ion (AF64A) were studied in neuroticized male Wistar rats. The cholinotoxin was bilaterally injected in the dose of 3 nmol. AF64A produced a significant decrease in arterial pressure and activity of respiratory enzymes succinate dehydrogenase and NADH-dehydrogenase in hippocampus and motor cortex. Increase in the local blood flow in the hippocampus and motor cortex had a compensatory character.

Animals↗