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N N Smirnova

Publications and source records attributed to N N Smirnova.

11 recordsLinked to original sources
PubMed1977

[Resistance of the suppressor function of T-cells to agents possessing an antiproliferative action].

Administration of cyclophosphamide in a dose of 50 to 400 mg/kg to mice immunized with sheep red blood cells failed to decrease significantly the capacity of the splenic cells of these mice to suppress the primary immune response in transplantation to intact syngeneic recipients. Irradiation of the donors of immune splenic cells (ISC) in a dose of 900 r or treatment of ISC in vitro with mitomycin C failed to influence their suppressor activity. Supernatant obtained after the ultracentrifugation of ISC treated with ultrasound inhibited the primary immune response of intact mice. A conclusion was drawn that the suppressor effect of ISC was caused by the factor produced by T-cells. Active proliferation of these cells was not necessary for the realization of its action.

Animals↗
PubMed1977

[Influence of several factors on the formation of immunologic memory].

Experiments were conducted on mice with the use of sheep erythrocytes as an antigen; the level of the secondary immune response of the spleen (in situ) cells or in adoptive transfer was in reverse relationship to the dose of erythrocytes used for primary immunization. Cyclophosphamide administered to the animals together with the antigen proved to stimulate the immune reaction of mice to the repeated erythrocyte administration; this occurred only in case of using comparatively high antigen doses for the priming. The mechanisms of the phenomenon described are discussed.

Animals↗
PubMed1976

[Drug-induced immune tolerance to sheep erythrocytes in mice of different lines].

Immunological tolerance to sheep erythrocytes was induced in mice of the CBA, C57BL/6, CC57BR, C3H, DBA/2 lines by means of combined administration of a high dose of the antigen and cyclophosphamide. The count of 19S antibody-forming cells was determined in the mouse spleen after the test injection of erythrocytes, by local hemolysis in gel. The extent of the tolerance induced proved to depend on the genotype of the animals; mice of the DBA/2 line were found to be most "sensitive" to its induction. There was revealed no correlation between the level of the immunological reactivity to sheep erythrocytes in the intact mice of different lines and the extent of its suppression in tolerance induction

Animals↗
PubMed1975

[Anal fissures].

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Fissure in Ano↗
PubMed1975

[Effect of "immune" RNA on various types of cells interacting in the immune response].

Simultaneous injection of marrow cells previously incubated with "immune" RNA, thymus cells and sheep red cells to X-ray treated mice resulted in a greater accumulation of antibody-forming cells in the spleen, as compared to mice inoculated with intact cells or with those incubated with normal RNA. Preliminary incubation of thymus cells with "immune" RNA did not affect the accumulation of antibody-forming cells. Incubation of peritoneal exudate cells with "immune" or normal RNA failed to influence the mode of accumulation of the antibody-forming cells either.

Animals↗
PubMedDate not supplied

[Na,K-Atpase in renal tissue of rats in the dynamics of experimental nephritis].

The authors undertook comparative study of the Na, K-ATPase activity in the red cells, ghost corpuscles, and in the cortex and medulla of kidneys of rats with experimental glomerulonephritis (GN) induced by injection of nephrotoxic serum (NTS), during an acute course of the process (1 and 2 weeks after NTS injection) and in chronic affection of the kidneys (10 weeks after NTS injection). The activity of the enzyme both in the red cells and in the ghost corpuscles was reduced significantly, by 28 and 22%, respectively, in the acute period of the disease (one week after NTS injection) but was restored to normal values in the period of chronic affection of the kidneys. The activity of the enzyme did not change in the cortex during the whole period of the study, but in the medulla it diminished in the acute period of the disease and remained reduced (by 27% on the average) during the chronic phase. It is concluded that reduction of the enzyme activity in the studied objects was not caused by the presence of endogenous inhibitors of the enzyme. It is suggested that reduction of Na, K-ATPase activity in the renal medulla may be one of the factors of increase of Na and water excretion in the urine in the chronic phase of GN.

Animals↗