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Biomedical subjects

N N Timofeev

Publications and source records attributed to N N Timofeev.

At least 19 recordsLinked to original sources
PubMed1985

[Neurochemical mechanisms of artifical hypobiosis and chemical thermoregulation].

Artificial hypobiosis in rats and rabbits was modelled using ornid which caused the blockade of neurotransmitter release from adrenergic neurons. The data obtained corroborated the hypothesis of the mechanisms of chemical thermoregulation as well as new ways of controlling these processes up to their complete blockade by means of decreasing adrenergic effects in the organism. Warm-blooded animals were transferred into poikilothermic state and then into hypobiosis under any given body temperature. At 18-20 degrees C, metabolism may be decreased to 1/10 of standard values and the state of hypobiosis may be maintained for a prolonged period remaining eversible without application of any drugs activating or blocking physiological functions.

Adrenergic Fibers↗
PubMed1976

[Schizophrenic and schizophrenic-like manifestations in syndrome 47, XYY].

The authors examined 4446 patients in mental hospitals. Among these patients 15 displayed the 47 XYY syndrome and 3 with mosaicism 46 XY/47 XYY. A study of these patients showed that in 5 cases they were qualified as schizophrenic. They were study died from 2-5 years. In 4 cases the diagnosis of schizophrenia was not confirmed. In one case the authors diagnosed the disease as an atypical form of schizophrenia. The clinical traits of the disease in this case are associated with a supplementary Y somasomia.

Adult↗
PubMed1975

[Use of guthimine for treatment of intestinal paresis in peritonitis under experimental and clinical conditions].

A new stimulator of intestinal peristalsis-guthymine (guanylthiourea) was used experimentally and clinically for treatment of the bowel paresis in peritonitis. Preliminary, in experiments on 53 rabbits with colibacillar peritonitis an efficacy of guthymine was compared with other stimulators of the gastrointestinal tract: proserine, a hypertonic solution of sodium chloride and sorbitol. Guthymine was found to be the most effective drug. Clinically, in 23 of 33 patients with intestinal paresis a drip administration of 15-50 mg/Kg of guthymine would provide for aborting the signs of paresis. In 8 patients a moderately pronounced effect was noted. In 2 cases the use of guthimine failed to produce any positive effects.

Animals↗