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Biomedical subjects

N N Vasil'eva

Publications and source records attributed to N N Vasil'eva.

At least 19 recordsLinked to original sources
PubMed2000

[Comparative study of isosorbide dinitrates and mononitrates in patients with ischemic heart disease and stable angina pectoris caused by stenosing coronary atherosclerosis].

In an open clinical trial 19 patients with angina pectoris (functional class II-III) received in turn either non-retard tablets of isosorbide dinitrate (nitrosorbid, cardiket) in a mean dose 80 mg/day or isosorbide 5-mononitrate (mono mac) in a mean dose 51.5 mg/day. Each drug was given for a month. The effect was assessed by changes in frequency of anginal attacks and exercise tolerance. Non-retard isosorbide dinitrate and isosorbide 5-mononitrate demonstrate a good antiischemic effect, are safe and well tolerated. Isosorbide dinitrate and mononitrates do not differ significantly in reduction of the anginal attacks and by an increase in exercise tolerance but the effective dose of mono mac was 1.5-2 times less than that of nitrosorbide or cardiket, thus it is more cost-effective.

Aged↗
PubMed2000

[Comparison of dinitrate isosorbide retard forms in ischemic heart disease patients with stable effort angina].

AIM: To compare antianginal and anti-ischemic efficiency and tolerance of two forms of isosorbide dinitrate--cardiket-retard 120 mg and cardiket-retard 40 mg in IHD patients with stable effort angina. MATERIAL AND METHODS: The study included 18 IHD patients with stable angina of functional class II (5 patients) and III (13 patients). The trial was open cross-over. The treatment with both the forms lasted 1 month. Frequency of anginal attacks and exercise tolerance by veloergometry data were assessed. RESULTS: A significant decrease in the number of anginal attacks and greater exercise tolerance was recorded in cardiket 120 mg intake once a day. Both forms were well tolerated, serious side effects were absent. CONCLUSION: Comparison of the two isosorbide dinitrate dosage forms--cardiket 120 mg once a day and cardiket 40 mg 3 times a day--showed that the former is superior by clinical efficiency.

Adult↗
PubMed2000

[Comparative study of retard and non-retard forms of isosorbide-5-mononitrate in coronary patients with stable angina pectoris].

An open cross-over trial compared retard and non-retard forms of isosorbide-5-mononitrate (monomac 50D and isomonat, respectively) in 15 patients with stable angina of effort (functional class II-III). Both drugs were found rather effective, they significantly increase exercise tolerance. A single daily dose of monomac 50D reduced the number of anginal attacks. It was well tolerated, caused no serious side effects and had advantages over isomonat taken 2 or 3 times a day.

Administration, Oral↗
PubMed1994

[The comparative efficacy of verapamil, nifedipine and propranolol in patients with IHD and an enhanced risk of a fatal outcome].

In a randomized controlled trial 329 postmyocardial infarction patients with high-grade ventricular extrasystoles were divided into 3 groups. Group 1 of 112 patients received calcium antagonists (verapamil, nifedipine, verapamil+nifedipine), group 2 of 100 patients received propranolol hydrochloride, group 3 consisted of 117 controls. The aim of the study was to elucidate the effect of the above drugs on sudden death and repeated nonfatal infarction risk. The mean follow-up duration made up 16 +/- 0.9, 16.8 +/- 1.1, 20.8 +/- 1.0 months for groups 1,2 and 3, respectively. 35 patients of the treatment groups turned out inappreciable because of early discontinuation of chemotherapy. Overall lethality for the groups 1, 2 and 3 reached 0.9%, 4% and 12% of patients, respectively. Most of lethal outcomes in the controls were sudden. Repeated nonfatal myocardial infarction arose less frequently in groups 1 and 2, but the difference was insignificant.

Adult↗
PubMed1989

[Relationship between the character of pathological changes in the esophageal mucosa and deficiency of several vitamins in a population with high incidence of esophageal cancer].

A comparative study of the esophageal mucosa versus vitamin status in the adult male population of Muinak District of the Karakalpak ASSR, characterized by high incidence of esophageal cancer, established a significantly high frequency of chronic esophagitis. The differential evaluation of different pathologies of the esophageal mucosa suggested a link between catarrhal and erosive esophagitis and vitamin B2 deficiency and atrophic esophagitis and vitamin A deficit.

Adult↗
PubMed1988

[Enzyme histochemical characteristics of the variants of kidney cancer].

Forty-seven specimens of renal cell carcinoma were studied using enzymatic histochemical (8 dehydrogenases and 3 hydrolases) and modern mathematical processing techniques. It was found that morphological variants of the tumor differed in enzymatic activity. This finding determines the possibility of employing specific enzymatic histochemical reactions in differential diagnosis. By the degree of differentiation morphological variants of hypernephroma can be entered into 3 groups: 1) clear cell carcinoma; 2) granular adenocarcinoma and sarcomatoid carcinoma; 3) mixed tumors. For clear cell carcinoma the activity of dehydrogenases and hydrolases enhanced with lesser differentiation of the tumor and vice versa for granular adenocarcinoma and carcinosarcoma. Poorly differentiated clear cell carcinoma is characterized by higher activity of dehydrogenases and hydrolases while granular adenocarcinoma and carcinosarcoma by lower activity of the enzymes compared to variants with well-differentiated tumor. These differences are due to specific cell structure of hypernephroma variants as well as their histochemical properties. There appeared a tendency to reduction of enzymatic histochemical polymorphism with a decrease in the differentiation of the tumor variant.

Adenocarcinoma↗
PubMed1982

[Effect of hyperbaric oxygenation on the cyclic nucleotide and catecholamine content, energy and carbohydrate metabolism and on cardiac contractile function in acute focal myocardial ischemia].

Two hours after the ligation of the descending branch of the left coronary artery in rabbits the contractile function of the heart decreased, concentration of phosphocreatine, ATP, glycogen dropped, and the content of lactic acid in the ischaemic and intact areas of the left ventricle elevated. Two-hour ischaemia of the myocardium was accompanied by increase of the cAMP and decrease of cGMP levels in the ischaemic and intact areas. Hyperbaric oxygenation (HBO, 2 at. abs, 1 h) started 30-40 min after coronary occlusion led to partial restoration of the cardiac contractility function, improvement of the energy and carbohydrate metabolism in the ischaemic and intact areas of the left ventricle and prevented cardiac fibrillation. It is surmised that favourable action of HBO on the functional state of the heart in its acute focal ischaemia is related not only to the antihypoxic effect but also to the rearrangement of the system of neurohormonal control of the heart.

Animals↗
PubMed1981

[Kidney cancer (modern concepts of its histogenesis, nomenclature and classification)].

Using their own and literature data the authors recommend that malignant epithelial renal tumors be termed as "renal carcinoma" or "renal cell carcinoma". The term "hypernephroid carcinoma" which is of only historical importance may be used as a synonym of clear cell renal carcinoma. Designation of all forms of renal carcinoma by the general term "renal adenocarcinoma" does not reflect all the diversity of structure of malignant epithelial renal tumors. This term may be used only in those cases where the "glandular" structure of the tumor is adequately evident. Four main forms of renal carcinoma may be distinguished according to the predominant morphological characteristics: clear-cell, granular-cell spindle-cell (sarcoma-like), and glandular (adenocarcinoma proper). According to the authors' data, 41% of renal carcinomas are represented by mixed forms.

Adenocarcinoma↗
PubMed1977

[Neurogenic stomach neoplasms induced by nitrosomethylures in Syrian hamsters].

In the experiment with inoculation of N-nitroso-N-methylurea (a maximum total dose of 7.5 mg) to Syrian hamsters, tumors developed in 20 out of 25 animals surviving the time of the occurrence of the first tumor (31 weeks). Out of 35 tumors 17 developed at the site of inoculation: in the left cheek pouch (of them 12 embryonal rhabdomyoblastomas), 11 in the stomach (of them 6 neurogenic), and 7 in other organs (skin, liver, adrenals, hemopoietic system). The paper describes the histological pattern of 6 neurogenic tumors of the stomach in which all the elements of the nervous system have been found: ganglionic cells, neuroglia, and nerve stems. On the basis of some signs the authors classify these tumors as malignant.

Animals↗
PubMed1977

[Spontaneous neoplasms in guinea pigs].

The authors present an analysis of the data of foreign literature and the results of their personal studies of spontaneous neoplasms in 40 guinea pigs of national breeding observed during observed during a 5-year period. In 4 of them malignant tumors were diagnosed-lympholeucosis (2 cases), dermoid ovarian cysts and also cancer and adenoma of the adrenal cortex (in one animal). The neoplasms described developed in guinea pigs, aged over 4 years, and they are referred to as mostly common tumors in this species of animals.

Age Factors↗