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N N Voĭtenko

Publications and source records attributed to N N Voĭtenko.

At least 19 recordsLinked to original sources
PubMed2001

[Effect of four mutations (Cr,S,S(H),h) in genes for mink coat color on brain monoamine oxidase].

Activity of A and B types of monoamine oxidase (MAO) has been investigated in the brain stem and brain hemispheres of mink males of five genotypes for coat-color mutations: standard dark-brown (+/+); heterozygous for the semidominant mutation Black crystal (Cr/+); homozygous for the semidominant mutation Black cross, or "95% White" (S/S); heterozygous for the semidominant mutation Shadow (SH/+); and homozygous for the semirecessive mutation hedlum white (h/h). The main changes in the activity of the A and B MAO types occur in the brain hemispheres. A reduced activity of MAO A has been recorded in the hemispheres of Black crystal minks (Cr/+) and an elevated activity, in the hemispheres of Shadow (SH/+) and 95% White (S/S). The activity of MAO B is reduced in the hemispheres of Black crystal and elevated in the hemispheres of hedlum white (h/h). An increased MAO A activity has also been recorded in the brain stem of Shadow minks (SH/+). It is suggested that genes controlling coat color have a pleiotropic effect on sexual behavior in males and the endocrine function of testicles mediated by a putative change in the metabolism of brain neurotransmitters, substrates of MAOs A and B.

Animals↗
PubMed1997

[Effect of domestication of the silver fox on the main enzymes of serotonin metabolism and serotonin receptors].

In silver foxes significant alterations in the activities of basic enzymes of neurotransmitter serotonin metabolism as well as in the densities of receptors caused by selection for the absence of the aggressive defensive reaction to man were demonstrated. In the midbrain and hypothalamus of animals selected for the absence of aggressive behavior, the activity of tryptophan hydroxylase, the key enzyme of serotonin biosynthesis, was found to be remarkably higher than in animals selected for highly aggressive behavior. Domesticated animals were characterized by low activity of the main enzyme of serotonin catabolism, monoamine oxidase type A, increased Michaelis constant km, and an unchanged maximum reaction rate (Vmax). No changes in the specific binding of [3H]-ketanserin and [3H]-8-OH-DPAT in the frontal cortex of domesticated foxes were revealed; however, in the hypothalamus, the low values of Bmax for the [3H]-8-OH-DPAT specific binding were observed, indicating the decreased density of the 5-HT1A receptors. It is assumed that the transformation of a wild aggressive animal into a domesticated one taking place during directional selection is caused by hereditary alterations favored by artificial selection in the activity of the main enzymes of serotonin metabolism and serotonin receptors.

Aggression↗
PubMed1996

[Effect of a single-locus mutation of the silver-blue color allele in mink on the dopaminergic system of the brain].

The peculiarities of dopamine metabolism and dopamine receptors in the brain of homozygous silver-blue (pp) minks were examined in comparison with wild-type (PP) minks. A pp mutation was found to affect the dopamine turnover in corpus striatum, which is one of the major dopaminergic brain structures. In silver-blue minks, increased dopamine catabolic enzyme activity monoamine oxidase type B (MAO B), together with the decreased level of dopamine and the tendency for the level of the metabolite 3,4-dihydrophenyl acetic acid to increase, were demonstrated in this brain region. No significant alterations in the level of another dopamine metabolite, homovanillic acid, or in D1 and D2 receptor density were shown. In the midbrain and hippocampus, an elevated level of MAO B activity was detected. We found no modifications in receptor properties, nor in dopamine turnover in a mesolimbic dopamine structure, the nucleus accumbens. We propose that the primary effect of pp mutation is an increase in MAO B activity resulting in dopamine turnover alterations and probably in dopamine-dependent behavior (pleiotropic cascade).

Alleles↗
PubMed1996

[Pleiotropic physiological effects of mutation di, which determines diabetes insipidus in rats].

The main phenotypic expression of mutation di is diabetes insipidus, which is pronounced in didi homozygotes. Additional physiological traits have been revealed that are associated with diabetes insipidus and are accounted for by the pleiotropic effect of gene di on the function of the reproductive system, metabolism of neurotransmitters in brain, and central regulation of the stress response. In didi mutants, the age-related decrease in fertility is retarded, the increase in B monoamine oxidase activity associated with aging is shifted to an older age, and the level of corticosteroid-binding globulin is decreased in young animals.

Aging↗
PubMed1996

[Monoamine oxidase activity in the brain of male laboratory mice differing in the capacity for social dominance].

The activity of type A and B monoamine oxidases (MAO-A and MAO-B) was studied in the brain stem and cerebral hemispheres of male mice from the PT and CBA inbred laboratory lines with opposite dominance capabilities and in their direct and reciprocal F1 hybrids. MAO-B activity was shown to be lower in the hemispheres of intact PT males and F1 hybrid males, which are genetically predisposed to social domination, than in CBA males. One-hour social stress imposed by grouping mice into a micropopulation resulted in a decrease in MAO-A and MAO-B activity in the hemispheres of dominant PT and F1 hybrid males and an increase in MAO-B activity in the brain stem of subordinant CBA and dominant F1 males.

Animals↗
PubMed1994

[The effect of the pleiotropic action of single-locus (pp) and dual-locus (aapp) mutation of mink fur color genes on serotonin metabolism in the brain].

Specific features of serotonin (5-hydroxytryptamine, 5-HT) metabolism were studied in the brain of mutant sapphire minks, homozygous at genes determining silver-blue and Aleutian fur color (ppaa), and silver-blue minks (pp) in comparison with the standard-colored minks (++/++). In the midbrain of sapphire mutants, the activities of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO), key enzymes of 5-HT biosynthesis and catabolism, were significantly higher; an increase in the 5-HT level was statistically nonsignificant due to considerable variation in this parameter; and the level of 5-hydroxyindole-3-acetic acid remained unchanged. A similar increase in TPH and MAO activities was also found in the midbrain of silver-blue pp minks, suggesting that activation of key enzymes of 5-HT metabolism in sapphire aapp minks is associated with the mutant alleles pp.

Animals↗
PubMed1992

[Sex steroid hormones and brain serotonin in the estrous cycle of silver foxes].

A significant increase in hypothalamic serotonin and estradiol levels was found in silver foxes during proestrus. During estrus, the plasma estradiol concentration was reduced and a significant increase in progesterone level was correlated with a decrease in the brain serotonin content. The data obtained suggest that the brain serotonin plays a mediating role in the control of ovarian hormonal activity and ovulation in silver foxes.

Animals↗
PubMed1990

[ Anticataleptic effect of delta sleep-inducing peptide and its action on brain monoamine oxidase in rats genetically predisposed to catalepsy].

Rats with genetic susceptibility to catalepsy (GC strain) were compared with Wistar rats (W). After an intraperitoneal administration of 120 micrograms/100 g delta sleep-inducing peptide (DSIP) in GC rats the duration of cataleptic freezing was shortened (13.8 +/- 9.5 sec against 27.2 +/- 7.5 sec in control). MAO-B activity decreased due to DSIP administration both in GC and W rats. It is hypothesized that the DSIP effect MAO-B in GC rats may correct the lost MAO-A function in deamination of dopamine, a common MAO-A and MAO-B substrate, and the dopaminergic neurotransmission in catalepsy.

Animals↗
PubMed1980

[Genetics and phenogenetics of the hormonal characteristics of animals. VII. Correlation between brain serotonin and the hypothalamo-pituitary-adrenal system in domesticated and undomesticated silver foxes during emotional stress].

Two groups of silver foxes, selected according their behaviour with respect to man and non-selected ones, were exposed to restriction-induced stress. It was found that changes in the level of brain serotonin and its main metabolite, 5-hydroxyindolacetic acid, and elevation of plasma corticosteroids concentration in domesticated (tame) silver foxes were much less pronounced than in non-domesticated (non-tame) animals. Positive relationship between type of behaviour, brain serotonin metabolism and pituitary-adrenal axis response to stress was observed. It is suggested that such correlative pattern as changed pituitary-adrenal axis responses in domesticated animals may be due to changes in metabolism of controlling this axis brain transmitter serotonin.

Animals↗
PubMed1977

[Relationship between oxidative deamination of cerebral seroton in during hibernation and changes in monoamine oxidase activity and temperature].

The highest MAO was found in alert ground squirrels and it became minimum in hibernating animals. The temperature relations of the oxidative serotonin desamination (OSD) in alert ground squirrels was relatively low from 7 to 37 degrees C. At the beginning of hibernation OSD did not differ from that of alert animals at 22--37 degrees C, while at 7--22 degrees C it was significantly lower--about 1.0. In hibernating ground squirrels, high OSD was observed at low and high temperatures in all parts of the brain except hypothalamus. At awaikening OSD remained high.

Animals↗
PubMedDate not supplied

[Brain monoaminoxidase during late ontogenesis in rats genetically predisposed to pendulum-like movements].

Rats genetically predisposed (PM+) and non-predisposed (PM-) to pendulum movement (spontaneous nystagm) were studied at different age. In old PM+ and PM- rats the brain MAO-A activity did not differ, unlike between young PM+ and PM- rats. In old PM+ and PM- rats, brain stem MAO-A activity was higher than in young ones. Actinomycin D lowered brain stem MAO-A activity in PM+ and PM- rats. In the absence of actinomycin D, stress elevated MAO-B activity in the brain stem of PM- rats, and a preliminary actinomycin D administration prevent the MAO-B activating effect of stress. Possible differences in MAO-A and MAO-B regulation at transcription level in PM+ and PM- are discussed.

Aging↗
PubMedDate not supplied

[Brain monoamine oxidase in prematurely aging OXYS rats].

Rats OXYS with manifestations of genetically determined premature aging and OXYR free from these manifestation were studied. Eight month old OXYS and OXYR rats were characterized by similar brain stem MAO A and MAO B activities and their control at the transcription level. In hemispheres of 8 month old OXYS rats MAO A activity was higher than in OXYR. Emotional stress did not affect either MAO A or MAO B in brain stem of the two strains, and lowered MAO A activity in hemispheres of OXYS rats.

Aging↗
PubMedDate not supplied

[Introduction of the human recombinant angiogenin at the early stages of postnatal development inhibits the growth of mice].

We studied the influence of recombinant DNA containing the cloned angiogenin gene, plasmid DNA without angiogenin gene, and purified recombinant angiogenin injected to Tg8 mice at the age of two days on the body mass of 28- and 40-day old mice. The body mass of mice that were injected with the cloned angiogenin gene or purified angiogenin was less than in the control mice. The body mice of Tg8 mice injected with recombinant DNA containing the cloned angiogenin gene did not increase from day 2 to day 40, while in the mice with purified recombinant angiogenin and control mice it increased by 24 and 57%, respectively. These data suggest that the elevated level of angiogenin at the early developmental stages inhibits the increase of body mass. The effect we described as related, in al likelihood, to the known inhibitory effect of angiogenin on protein synthesis.

Animals↗
PubMedDate not supplied

[Brain monoamine oxidase in mink selected for their reaction to man].

Monoamineoxidase activity was studied in minks of three behavioural groups--those bred for absence of aggression towards man, those bred for high aggression to man, and those of non-selected population. Breeding for the absence of aggression was accompanied by a decrease of MAO-B activity with unchanged MAO-A activity. The minks bred for aggressive behaviour towards man, as compared to those bred for the absence of aggression, were characterised by increased MAO-A and MAO-B activities in the brain stem. The effect of emotional stress on MAO-A and MAO-B was similar in aggressive, non-aggressive and unselected minks and was expressed in a decrease of both MAO-A and MAO-B activity. The MAO activity of cerebral hemispheres remained unaffected both by selection for behaviour and by the emotional stress.

Aggression↗
PubMedDate not supplied

[The predisposition to catatonic reactions, monoamine oxidase and the delta-sleep peptide in rats].

MAO B/MAO A rations and the influence of delta-sleep inducing peptide (DSIP) on the two forms of MAO and on the predisposition to different types of catatonic reactions were compared in rats of GC strain selected from Wistar for predisposition to catalepsy, and in wild rats. In GC rats, the MAO B/MAO A ratio was increased, as compared to Wistar, in the brain stem and hemispheres, whereas in wild rats predisposed to catatonia it was increased, as compared to normal wild rats, only in the hemispheres. In GC rats, this increase of the MAO B/MAO A ratio was due to a decrease of MAO A and increase of MAO B activity, while in wild catatonic rats only due to heightened MAO B activity. Administration of DSIP abolished the susceptibility to catatonic reactions and normalized the MAO B/MAO A ratio both in GC and in wild catatonic rats. There seems to be a partial similarity of physiological mechanisms of catatonic reactions in laboratory albino and in wild rats.

Animals↗