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Biomedical subjects

N N Zybina

Publications and source records attributed to N N Zybina.

12 recordsLinked to original sources
PubMed2004

[Chromosomal aberrations and parameters of oxidative stress in Chernobyl clean-up workers in a remote period after ionizing radiation].

This investigation was performed to test a supposition about the influence of disturbances in antioxidative system on cytogenetical parameters in Chernobyl' clean-up workers. It was shown that some cytogenetical parameters straightly correlated with the parameters of oxidative stress, while other cytogenetical parameters show just reverse correlations. Apparently, these relationships are not of cause-and-effect type, but they reflect a complex processes occurring in humans for a long period after radiation exposure.

Cells, Cultured↗
PubMed2004

[Influence of smoking on the cerebral hemodynamics and biochemical blood indices in chronic insufficiency of brain circulation].

The influence of smoking on cerebral hemodynamics and biochemical blood indices has been studied in 50 male patients with chronic insufficiency of brain circulation (CIBC), aged 40-50 years, divided into 2 groups: smoking (n=26) and nonsmoking (n=24). Smoking was shown to play a substantial role in the development of discirculatory encephalopathy with atrophic brain changes, causing metabolic disturbances (a shift of acid-basic balance towards acidosis) and microcirculation disorders due to altered cerebrovascular reactivity. These alterations develop previously to hemodynamically significant atherosclerotic arteries lesion and emerge irrespective of the presence of atherosclerotic vascular changes, atherogenic shifts of lipid metabolism, disturbances of free-radical processes and platelet aggregation.

Brain↗
PubMed1990

[Effects of impulse hydrodynamic influences on blood cells in vitro and in vivo].

Impulse hydrodynamic influences (IHDI) resulted in an increase of accumulation of acridine organ, degranulation of neutrophils, decrease in adenylate cyclase and Na+, K+, Mg2(+)-dependent ATPase activities in the white blood cells of man and rat in vitro and in vivo. It was found that the cell's response to one-fold IHDI was more pronounced than to 5-fold IHDI. It was suggested that in certain conditions IHDI could lead to a decrease in reactivity of white blood cells.

Acridine Orange↗
PubMed1990

[Treatment of gunshot wounds of soft tissues].

The authors have determined principal directions of a complex and successive action on the wound process taking into account its phasic character and new ideas as the dynamics of zonal disturbances of microcirculation around the gunshot wound. The use of the systemic treatment of 44 patients with gunshot wounds of soft tissues allowed the period of treatment to become 1.5 times shorter and the amount of suppurations was 4 times less.

Animals↗
PubMed1989

[Viability of tissues of the extremities and surgical tactics in stage IV arteriosclerosis obliterans].

Amputation of the extremity was performed in 26 of 52 patients with the IV stage obliterating atherosclerosis. Clinical severity of the disease was confronted with results of special investigations. Three groups of such patients are described: with traumatic necroses, with ischemic necroses and with necrotic ischemia (criteria of its irreversibility are presented). Surgical tactics of treatment in the first group of patients may include sympathectomy with necrectomy. The outcome of treatment of the second group patients is determined by the efficiency of reconstructive operations. Amputation of the extremity is indicated to patients of the third group.

Amputation, Surgical↗
PubMedDate not supplied

[Oxidative modification of blood plasma proteins in elderly people with vascular dementia].

We examined the spontaneous and metal-ion-catalyzed oxidative modification plasma blood proteins in the group of healthy adults and elderly ones and patients with vascular dementia (mild and severe). We determined the spectrophotometric measurement of 2,4-dinitrophenylhydrazone derivatives formed by reactions with protein carbonyls. The level of metal-ion-catalyzed oxidation proteins in the aged patients both with and without dementia was high in comparison to the healthy adults. The patients with severe dementia showed lower amount of 2,4-dinitrophenylhydrazone deriviates. Low levels of metal-ion-catalysed protein oxidation strongly correlated with the degree of psychoorganic disturbances. The elderly persons with both and without dementia showed a high level of plasma nonenzymatic H2O2 scavenging in comparison with the healthy adult ones. We discovered an imbalance between enzymatic and nonenzymatic components of the antioxidant system. The latter indicates that the oxidative modification of brain tissue proteins probably plays an important role in aging and mental disorders.

Adult↗
PubMedDate not supplied

[Activation of the processes of lipid peroxidation in the small-intestinal mucosa and liver in peritonitis and possible ways of their correction by a complex infusion-detoxification therapy].

Possibilities of lipid peroxidation (LPO) correction by infusion-detoxication therapy in peritonitis were studied in an experiment on 160 white rats and during clinical treatment of 88 patients with general peritonitis. It was shown that peritonitis development in rats was attended by an increase of LPO products--malonic dialdehyde and diene conjugates, in the hepatic tissue and small intestine mucosa, while the activity of antioxidant defense elements--superoxide dismutase and fat-soluble antioxidants, decreased. It was noted that LPO became normal after intravenous administration of exogenous superoxide dismutase (6 mg/kg) and the blood substitute Mafusol containing Krebs cycle substrate--sodium fumarate (9 ml/kg). Inclusion of Mafusol into the combined therapy of patients with general peritonitis contributed to the reduction of malonic dialdehyde and diene conjugate levels in the blood, normalization of its acid-base state, diminution of medium mass molecule content. Similar normalization of LPO was not recorded when lactosol was used. It has been concluded that blood substitute Mafusol used in the combined therapy of patients with general peritonitis significantly raises the treatment effectiveness.

Animals↗
PubMedDate not supplied

[The results of the drug therapy of the ischemic syndrome in arteriosclerosis obliterans].

A thorough investigation of 120 patients with obliterating atherosclerosis of lower extremities, treated conservatively at a hospital and observed for 5 years have shown that such a treatment was most effective in patients with the initial stages of the disease. The mechanisms of positive effects is based on the dilatation of the peripheral arteries and the resulting decrease of the peripheral resistance of the vessels, improved cardiac activity, activation of microcirculation and tissue respiration. An important result of the treatment is an increased rate of the oxygen consumption by the tissues in the ischemic zone. It determines the pathogenetic direction of the therapy which leads to a delayed progress of the disease in 20% of the patients and improves the patient's state in 57% of cases.

Adult↗