Biomedical subjects

N Nicolov

Publications and source records attributed to N Nicolov.

17 recordsLinked to original sources

PubMed1990

[The effect of vitamin E on the survival rate and biochemical parameters such as isocitrate dehydrogenase, lactate and selected peptidases and proteases during endotoxic shock in the rat].

Protective effect of the investigated alpha-tocopherol solution regarding survival and changes of several biochemical parameters in rat endotoxin shock could already be demonstrated after application of the solvent (special oil HCO-60) alone. An additional effect of Vitamin E was observed only in DP IV activity and leukocyte counts.

Animals↗

PubMed1989

Decreases in left ventricular contractility during endotoxin shock in rabbits.

The participation of the heart in shock syndrome formation during endotoxin shock is a problem still awaiting solution. The task undertaken is to assess the work of the left ventricle and arterial pressure in rabbits before and after endotoxin injection at a dose of 2 mg.kg-1. Heart rate is the first to reach significantly lower values--at 30 min (p less than 0.05). At 45 min, there are significant reductions in dP/dtmax (p less than 0.01), (dp/dt)/P40 (p less than 0.001), LVP (p less than 0.05), and increase in dP/dtneg (p less than 0.02). Both the systolic and diastolic blood pressures were significantly decreased at 60 min. The data obtained warrant the assumption that impaired myocardial contractility plays a part in the formation of shock syndrome in rabbits exposed to endotoxin.

Animals↗

PubMed1988

A new method for the management of ureteral colic after extracorporeal shock wave lithotripsy.

In ten patients, who underwent ESWL of renal calculi and had severe ureteral colic due to acute obturation of the ureteral lumen by larger stone fragments, i.v. glucagon injections combined with laevulose infusion were applied. All patients reported relief of pain and discomfort within 15-20 minutes after glucagon injection. Position of the stones in the ureter was regularly checked. No particular adverse effects of glucagon were noted. Glucagon increases GFR and diuresis and exhibits spasmolytic effect on the smooth muscle of the ureteral wall, thus facilitating the passage of stone fragments after ESWL. In certain cases and with certain indications we recommend the method as highly effective.

Adult↗

PubMed1988

Effect of calcium blocking agent verapamil on blood pressure, ventricular contractility, parathyroid hormone, calcium and phosphorus in plasma, catecholamines, corticosterone and plasma renin activity in spontaneously hypertensive rats.

In four-month-old spontaneously hypertensive rats (SHR) the effect of a calcium blocking agent verapamil on blood pressure, ventricular contractility indices, parathyroid hormone (PTH), plasma renin activity (PRA), plasma and adrenal corticosterone content and catecholamines in hypothalamus, myocardium and adrenal gland was evaluated. Calcium and phosphorus in plasma were also determined. Verapamil treatment resulted in a significant decrease in systolic and diastolic blood pressure and a reduction in maximum left ventricular pressure. Verapamil exerted a negative inotropic effect, evaluated by a decrease in dP/dt max and dP/dt neg. PRA was elevated, calcium tended to decrease, and no changes in PTH and phosphorus were found. The hypotensive effect of verapamil in SHR was accompanied by a decrease in plasma and adrenal corticosterone content, and a fall in catecholamine concentration in adrenal glands and myocardium.

Animals↗

PubMed1986

Effect of captopril on some ventricular contractility indices in spontaneously hypertensive rats (SHR).

Two groups of SHR were treated with captopril (Squibb): the first group (1 month old)--30 mg/kg i.p. twice daily for 77 days, and the second group (8 months old)--20 mg/kg p.o. twice a day for 23 days. The recording of electrocardiogram (ECG), systolic blood pressure (SBP), diastolic blood pressure (DBP), and some isometric indices of the left-ventricular contractility indicate that in all treated animals the values of most of the parameters are considerably lowered compared to the controls. The ratio between velocity of pressure increase and intraventricular pressure/equal to 50 mmHg--(dP/dt)/ICP50/does not change significantly. It can be concluded that in SHR, captopril practically does not influence the inotropic condition of the myocardium.

Animals↗

PubMed1986