Biomedical subjects

N O Berg

Publications and source records attributed to N O Berg.

53 records · Page 3Linked to original sources

PubMed1977

Radiotherapy and surgery in 50 cases of osteosarcoma treated without adjuvant chemotherapy.

A consecutive series of osteosarcoma patients from one hospital is described. In 1962 radiotherapy with delayed surgery according to Cade was replacing surgery alone as the adopted treatment programme. Statistically the results were the same before and after this time with 5 out of 29 and 6 out of 21 patients, respectively, surviving 5 years. With radiation alone none out of eight survived. Surgery alone produced 3 out of 14 and radiation with delayed surgery 6 survivors out of 15. As surgery with or without radiotherapy is equally ineffective in controlling osteosarcoma a prospective randomized trial of the relative merits of chemotherapy and interferon as adjuvant therapy seems highly desirable.

Adolescent↗

PubMed1976

Repeat scintigraphy of the internal mammary lymph nodes in rabbits.

Rabbits were subjected to different combinations of scintigraphy of the internal mammary lymph nodes, fractionated irradiation, and surgical trauma to the chest wall. No influence could be demonstrated on the image at repeat scintigraphy of the internal mammary nodes. Microscopic changes in the lymph nodes and vessels were relatively slight and inconstant.

Animals↗

PubMed1976

Fine needle aspiration biopsy in the evaluation of tumor-like lesions of bone.

A consecutive series of bone lesions suspected to be tumors and examined by fine needle aspiration biopsy at the University Hospital Cytology Laboratory in Lund, Sweden, is reported. From 1966 to November 1974, 150 cases were examined. In 123, sufficient cellular material was obtained through aspiration by a needle with an outer diameter of 0.8 mm. The method is described. The reliability of cytology is compared with the results of the definite pathology after open biopsy or extirpation of the lesion. In the series of primary benign lesions 28 out of 39 were correctly diagnosed; among primary malignant 27 out of 38 were correct and among metastases 57 out of 73 were correctly diagnosed including those where insufficient cellular material was aspirated. In cases where sufficient material was achieved the reliability of the cytological diagnosis was around 90 per cent. There was one false positive and two false negative reports of malignancy. Fine needle aspiration biopsy with cytology is recommended as a standard step in orthopedic oncological examinations. It has at least the same degree of diagnostic reliability as other diagnostic methods, such as X-ray, for instance; however, it does not replace open biopsy and histology when mutilating surgery is in question.

Biopsy, Needle↗

PubMed1975

Intestinal disaccharidases in Greenland Eskimos.

Jejunal biopsies from 19 adult Greenland Eskimos were studied regarding disaccharidases, two intracellular beta-galactosidases, and morphological appearance. Fifteen of the patients (79%) had low lactase activity, and 3 of these (16%) had sucrase-isomaltase deficiency as well. Two patients had low trehalase activity. Microscopical appearance was essentially normal in all the biopsies, except for a certain stromal plasma cell infiltration. All the patients with low lactase activity had a measurable residual activity of brush border lactase, which was localized in the middle and apical parts of villi, as normally seen for digestive enzymes. Lysosomal acid beta-galactosidase and cytosol hetero beta-galactosidase were not altered. In the patients with sucrase-isomaltase deficiency there was a complete absence of active sucrase-isomaltase complex. The residual maltase, as well as the very weak residual isomaltase, was exerted exclusively by the heat stable maltases (maltase II and III). The material is the first one in which multiple, but not generalized disaccharidase deficiencies are demonstrated.

Adolescent↗

PubMed1975

Distribution of disaccharidases, alkaline phosphatase, and some intracellular enzymes along the human small intestine.

The longitudinal distribution of various enzymes along the human small intestine was studied by analysis of biopsies from different parts of the small intestine, obtained from 13 patients during shunt-operation for severe obesity. Alkaline phosphatase and 3 glycolytic enzyme activities studied were rather uniformly distributed along the small intestine. Acid beta-galactosidase and hetero beta-galactosidase activities were highest in the proximal small intestine with a gradual decline throughout the intestine. The activity in the distal ileum was about half of the maximum activity. Maltase, isomaltase, sucrase, and trehalase activity had a broad maximum in the proximal and middle small intestine with a rather sharp decrease in the distal ileum. Lactase activity had a more pronounced maximum in the middle intestine with a pronounced decrease towards the proximal and distal ends. The disaccharidase activities in surgical biopsies taken 5 cm distal to the ligament of Treitz were about 10% higher than in peroral biopsies taken just at the ligament.

Adult↗

PubMed1974