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Biomedical subjects

N O Ericsson

Publications and source records attributed to N O Ericsson.

At least 19 recordsLinked to original sources

Results of hypospadias repair according to the principle of the buried strip.

The results after hypospadias repair according to methods of Denis Browne and Crawford area evaluated. Chordee release was performed in 361 patients, 41 or 11% of whom had a reoperation. Urethroplasty was done in 479 patients, 372 according to Denis Browne and 107 according to Crawford. Postoperative fistula or rupture of the plasty was recorded in 27% after Denis Browne's method and in 32% after Crawford's method. Stricture formation was low (3%) in all the patients. The use of polyglycolic acid suture in hypospadias repair caused more fistulas than if nylon was used (P less than 0.05).

Humans↗

Urodynamic studies in boys with disorders of the lower urinary tract. IV. Congenital bladder neck obstruction. A pre- and postoperative study.

Eighteen boys with diagnose of bladder neck obstruction, based on roentgenological criteria, underwent urodynamic investigations. In the majority of patients, urodynamics clearly deviated from the normal range, substantiating that bladder neck obstruction, although rare, really exists in male infants and children. A rather uniform radiographic appearance of the bladder neck was associated with different urodynamic patterns, suggesting that various pathophysiological mechanisms may be involved.

Child↗

Urodynamic studies in boys with disorders of the lower urinary tract. I. Urethral strictures. A pre-and postoperative study.

Sixteen boys with urethral strictures underwent urodynamic investigation pre- and postoperatively. The intravesical pressure preoperatively showed wide variations during micturition and was increased in only half of the patients. The urinary flow pre-operatively displayed a uniform picture with a decreased maximum flow in all the patients, plateau-formation and slow initiation of the flow curve. The maximum exit velocity of the urinary stream was decreased and the urethral energy losses were very high. After treatment, the out-flow situation was generally improved, but restored to normal only in some cases. Patients with short strictures showed the highest degree of urethral obstruction, but they also seemed to have the best prognosis, some of them even reaching supernormal flows. Flow measurement alone is recommended in the long-term follow-u, which is necessary in these patients. After-contraction was not present in any of the patients pre-operatively, blt occurred in about half of them postoperatively. This and some other findings may indicate the existence of functional changes in the bladder neck in patients with urethral stricture. On case with partial detrusor muscle insufficiency is reported.

Child↗

Long-term results in surgical treatment of posterior urethral valves.

In a series of 44 boys operated on for urethral valves more than 10 years ago two died. In the surviving patients, hydronephrosis and hydroureters improved markedly in 4/5, infection disappeared in 3/4, renal function seemed to normalize in more than 1/2. All valves arose from the anterior wall of the prostatic urethra. Consequently, transurethral resections were done anteriorly. Preoperative treatment was restricted to temporary correction of dehydration and acidosis for some hours or a few days. Otherwise, uremia is no contraindication.

Adolescent↗

Effect of vesicoureteral reflux on renal function in children with recurrent urinary tract infection.s.

The functional damage caused by vesicoureteral reflux (VUR) has been examined by unilateral clearance studies in 22 children with recurrent urinary tract infection (UTI) and representing 23 kidneys with large VUR. 7 kidneys with small to moderate VUR and 14 kidneys without VUR. Inulin clearance, Na+ excretion and glucose reabsorption were determined. In kidneys without or with small and moderate VUR, UTI had no effect on renal function if treated. In kidneys with large VUR extending into the pelvis and dilating the ureter, there was a gradual deterioration of glomerular filtration rate (GFR) that was accelerated after the age of 6 yr. Before puberty more than 50% of renal function was lost despite strict medical care of the UTI. If this functional loss was unilateral, hyperfunction of the contralateral kidney was generally observed. Maximal glucose reabsorption was depressed in proportion to GFR. In kidneys with unilaterally low GFR, the fractional Na+ excretion was consistently increased as compared to the contralateral kidney with normal GFR. This adaptive increase in Na+ excretion must therefore be of intrarenal origin.

Adolescent↗

Considerations on treatment of nephroblastoma. A study of 36 cases.

Thirty-six patients with nephroblastoma in Stages I, II and III treated at Radiumhemmet between 1966 and 1973, were analysed. The tumors were classified into three different histological types. All 10 patients in Stage III have developed metastases. All patients in Stages I and II (5 out of 26) who developed metastases had poorly differentiated (histological Type III) tumours. The indications for postoperative irradiation and chemotherapy for the different stages and histological types of the tumour are discussed.

Child↗