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Biomedical subjects

N O Nuessle

Publications and source records attributed to N O Nuessle.

10 recordsLinked to original sources
PubMed1982

Development and utility in externship of a questionnaire on attitudes toward professional roles of the pharmacist.

A sixty-six item questionnaire was developed to measure students' attitudes toward pharmacy as a profession, professional principles, and their preparation for the profession. It was administered to three consecutive year graduating classes (1978, 1979 and 1980) both pre- and postexternship so that changes in attitudes during the eight week experience program might be examined. Factor analysis was used to select items which could be combined to form scales (factors). The questionnaire yielded stable responses. The responses of the three classes to the scales were positive both before and after externship in regard to students' adherence to professional values. Mean responses on the scales showed some change during the 1980 externship; the most significant being that students felt better prepared for the profession after their externship.

Attitude of Health Personnel↗
PubMed1982

Stability of diazepam injection repackaged in glass unit-dose syringes.

The stability of diazepam injection repackaged in disposable glass syringes and stored at room and refrigerator temperatures was studied. Thirty-nine 1.5-ml syringes were filled with 1.1 ml diazepam injection 5-mg/ml. All syringes were stored in light-resistant bags on their sides so that the solution was in contact with the rubber stoppers on both ends. Samples were assayed with a stability-indicating HPLC method for diazepam and its degradation product, 2-methylamino-5-chloro-benzophenone (MACB), after 30, 60, and 90 days of storage at 30 degrees C and 4 degrees C. At 90 days, the diazepam injection stored at 4 degrees C retained 97.4 +/- 1.6% of its original potency; samples stored at 30 degrees C retained 92.4 +/- 1% of their original potency. Apparent sorption to rubber syringe components led to a decrease in the concentration of both diazepam and MACB. The decrease in diazepam was a function of storage time and temperature; however, the disappearance of MACB from the syringes was a function of only time. Diazepam injection is chemically stable as 5-mg doses in disposable glass syringes for 90 days when stored at 4 degrees C or 30 degrees C. However, refrigeration is recommended.

Diazepam↗
PubMed1981

Stability of lidocaine hydrochloride in 5% dextrose injection in plastic bags.

The stability of lidocaine injection mixed with 5% dextrose injection and refrigerated or stored at room temperature was studied. Lidocaine injection was added to 5% dextrose injection to provide a lidocaine hydrochloride concentration of 4 mg/ml. Samples were assayed for lidocaine and its degradation product, 2,6-dimethylaniline, after 30, 60, and 120 days of storage at room temperature (30 degrees C) and refrigerated temperature (4 degrees C). The analysis was by a stability-indicating HPLC method. Degradation product 2,6-dimethylaniline was not detected at any assay time at either temperature. No statistically significant loss of lidocaine occurred at either temperature. Lidocaine hydrochloride injection is chemically stable for up to 120 days at either 30 degrees C or 4 degrees C when mixed with 5% dextrose injection in plastic infusion bags.

Adsorption↗
PubMed1976

Correlation of absorption of sulfamethazine boluses with dissolution using a new dissolution apparatus for veterinary tablets.

A rotating-basket apparatus for dissolution testing of veterinary bolus tablets was designed and constructed. Sulfamethazine boluses containing different disintegrating agents were evaluated in vitro and by blood level data following administration to cattle. The dissolution t50 and various pharmacokinetic parameters showed directly compressible starch and carboxymethylstarch to be the most effective disintegrants in the concentrations employed while magnesium aluminum silicate and microcrystalline cellulose were about equal but less effective than the previous disintegrants. A bolus formulation containing no disintegrant gave even less satisfactory results. A correlation was established between the dissolution t50 and the time to peak plasma level and also between the t50 and the area under the plasma-time curve for the first 36 hr.

Animals↗
PubMed1975

Viscosities of acacia and sodium alginate after sterilization by cobalt-60.

Acacia and sodium alginate powders were sterilized by cobalt-60 irradiation to a total dose of 2.5 Mrad with no increase in residual radioactivity of the gums as a result of the treatment. Viscosity measurements showed an 11% reduction in the viscosity of acacia in water and a 16% decrease in the intrinsic viscosity in barium chloride solution due to the irradiation. Viscosities of sodium alginate solutions in 0.1 N sodium chloride showed a 70% decrease in intrinsic viscosity, indicating changes in the molecular structure corresponding to degradation to 30% of the original degree of polymerization. This dose of gamma-radiation from cobalt-60 is not an appropriate method of sterilization for these gums.

Acacia↗
PubMed1975

Characterization of hydrogen bonding between selected barbiturates and polyethylene glycol 4000 by IR spectral analysis.

Several barbiturates and primidone were equilibrated with polyethylene glycol 4000 in pyridine. IR spectral properties of these samples indicate that seven disubstituted barbiturates complex with polyethylene glycol 4000 while five disubstituted barbiturates and two trisubstituted barbiturates as well as primidone do not. Forces responsible for complexation of barbiturates with polyethylene glycol 4000, as inferred from spectral data, consist of hydrogen bonds formed between N1 and N3 hydrogens of the barbiturate ring and two oxygen atoms of the --O--CH2CH2--O--moiety. Also, there appear to be three configurations of intermolecular hydrogen bonding sites between disubstituted barbiturates. Several factors affect the barbiturate-polyethylene glycol 4000 interaction, including the nature of the solvent, C5 substituents, the number of hydrogen bonds formed between reactants, and the 2-carbonyl group of the barbiturate ring. Complexes of polyethylene glycol 4000 with phenobarbital, butabarbital, and cyclobarbital are stable in water at 26 degrees or below, but complexes of polyethylene glycol 4000 with butethal, cyclopentenyl allylbarbituric acid, pentobarbital, and probarbital are not.

Barbiturates↗
PubMedDate not supplied

Oestrone loaded poly(l-lactic acid) microspheres: preparation, evaluation and in vitro release kinetics.

Poly(l-lactic acid) microspheres containing oestrone were prepared by the solvent evaporation method using methylene chloride as the casting solvent and poly(vinyl alcohol) as the emulsifier. Non-agglomerated microspheres with average diameters of 125-160 microns, containing 3-18 per cent oestrone were prepared successfully using a stirring rate of 650 rpm and a poly(vinyl alcohol) concentration as low as 0.15%. Drug loading decreased with an increase in the relative amounts of methylene chloride or emulsifier. Microspheres with 9 per cent loading released approximately 50 per cent of the drug in the first 12 h and the remainder at a much slower rate over several days. Initial examination revealed that the kinetic data followed both a first-order release pattern and the Higuchi matrix model. Differential rate treatment confirmed the Higuchi matrix model and the release mechanism was determined to be diffusion-controlled.

Delayed-Action Preparations↗