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Biomedical subjects

N Ogino

Publications and source records attributed to N Ogino.

At least 19 recordsLinked to original sources
PubMed1997

Change in postoperative refractive error when vitrectomy is added to intraocular lens implantation.

PURPOSE: To compare the actual and expected refractive errors after intraocular lens (IOL) implantation alone with those after IOL implantation with simultaneous vitrectomy. SETTING: Shinjo Eye Clinic, Miyazaki, Japan. METHOD: One hundred thirty-six eyes had cataract extraction and implantation of a single-piece IOL using a frown incision, continuous annular anterior capsule tear, phacoemulsification, and intracapsular lens fixation. Thirty-six eyes also had vitrectomy. RESULTS: Mean postoperative refractive error was 0.55 diopter (D) +/- 1.34 (SD) in eyes having no vitrectomy and 0.04 +/- 1.24 D in those having vitrectomy. The difference between groups was statistically significant (P = .047; t-test). CONCLUSION: The refraction after simultaneous IOL implantation and vitrectomy shifted toward myopia by a mean of 0.50 D compared with that after IOL implantation alone.

Adult↗
PubMed1997

[Results of vitrectomy for macular packer after reattachment surgery for rhegmatogenous retinal detachment].

I analyzed the visual results in 184 eyes which had undergone vitrectomy and membrane peeling for macular pucker following treatment for rhegmatogenous retinal detachment. Patient age ranged from 9 to 83 (mean : 55) years, time between reattachment surgery and vitrectomy from 3 to 63 (mean : 15) months, and follow-up from 12 to 96 (mean : 39) months. For the analysis, visual acuity was examined 12 months after the last surgery in 93 pseudophakic eyes and 38 phakic eyes (patients age < 45) and 6 months in 53 phakic eyes (patient age > or = 45). When Y = log 1.5-log (postoperative acuity) and X = log 1.5-log (preoperative acuity), the regression line Y = 0.421 X (R2 = 0.765, p < 0.0001) was obtained. The regression line was Y = 0.395 X (R2 = 0.759, p < 0.0001) for pseudophakic eyes, and Y = 0.488 X (R2 = 0.777, p < 0.0001) for phakic eyes. Thus postoperative visual acuity was higher in pseudophakic eyes than in phakic eyes. When calculated from the pseudophakic line, mean postoperative acuity was 0.2 for preoperative acuity of 0.01, 0.5 for 0.1, and > 1.0 for > 0.5. Postoperative acuity was inversely correlated with the duration between reattachment surgery and vitrectomy (R2 = 0.544, p < 0.0001), and with the patient age (R2 = 0.0046, p = 0.0033). Better postoperative acuity, therefore, was associated with earlier vitrectomy.

Adolescent↗
PubMed1997

[Vitreous surgery for macular hole followed membrane peeling].

We performed vitreous surgery for macular holes following membrane peeling. The cases were five eyes of five females aged 42 to 67 years at the time of membrane peeling, out of 441 eyes of 414 patients who underwent membrane peeling. One eye had secondary epiretinal membrane combined with ocular sarcoidosis, two eyes had idiopathic epiretinal membrane, and two eyes had idiopathic vitreoretinal traction syndrome. The presumed interval from membrane peeling to macular hole formation was 5 to 90 months (average 14 months). For treatment of the macular holes, membrane peeling and SF6 gas tamponade were performed. In four eyes of the five eyes, the macular hole was closed. In the remaining eye, removal of the retinal pigment epithelium from the base of macular hole and application of fibrin glue were used in addition to SF6 gas tamponade, but the macular hole was not closed. The follow-up term was 10-24 months (average 17.6 months). Geometrical mean visual acuity was 0.34 before membrane peeling, 0.94 at maximum after membrane peeling, 0.19 after macular hole formation, 0.51 at maximum after macular hole surgery, and 0.44 at the final visit.

Adult↗
PubMed1997

Trabeculotomy combined with phacoemulsification and implantation of an intraocular lens for the treatment of primary open-angle glaucoma and coexisting cataract.

BACKGROUND AND OBJECTIVE: The authors previously reported the usefulness of trabeculotomy ab externo for the treatment of primary open-angle glaucoma in adult patients. In an attempt to elucidate the long-term risk-to-benefit ratio of this surgical modality in combination with cataract surgery, the authors conducted a retrospective study of the surgical effects and complications of a triple procedure: phacoemulsification, implantation (of an intraocular lens), and trabeculotomy (PIT). PATIENTS AND METHODS: The authors conducted a retrospective study of patients treated with PIT at multiple hospitals. Intraocular pressure (IOP) and visual function data were obtained from patients after PIT as an initial surgical treatment in cases where antiglaucoma medications failed to resolve uncontrolled IOP (higher than 21 mm Hg). Included in this study were 96 eyes of 64 patients with primary open-angle glaucoma and coexisting cataract. The mean follow-up period was 22.6 +/- 14.7 months (range 3-56 months). RESULTS: In 94 (98%) of the 96 eyes, the IOP was well controlled, having achieved a level of 21 mm Hg or lower at the final examinations. The mean preoperative IOP of the 33 eyes that underwent the triple procedure using a single flap method (PIT-I) was 24.3 +/- 3.9 mm Hg, with an average of 2.1 +/- 1.1 medications. At the final examinations, the mean IOP had dropped to 16.0 +/- 1.2 mm Hg, with an average of 1.2 +/- 1.2 medications. The mean preoperative IOP of the 63 eyes that underwent the triple procedure using a double flap method (PIT-II) was 26.2 +/- 6.2 mm Hg, with an average of 1.9 +/- 1.2 medications. At the final examination, the mean IOP for this group was 15.6 +/- 2.9 mm Hg, with an average of 1.0 +/- 0.9 medications. CONCLUSION: The long-term results from this multicenter study showed that the triple procedure, PIT, can be useful and effective as an initial surgical treatment for open-angle glaucoma in glaucoma patients with coexisting cataract.

Adult↗
PubMed1996

Vitrectomy for diffuse macular edema in cases of diabetic retinopathy.

PURPOSE: To ascertain the effects of posterior vitreous detachment for diffuse diabetic macular edema. METHODS: We performed vitrectomy on 58 eyes of 41 consecutive patients with diabetic macular edema without posterior vitreous detachment. Follow-up was done at 12 months postoperatively. RESULTS: In 57 of 58 eyes after vitrectomy and posterior vitreous detachment, macular edema resolved, and diffuse fluorescein leakage disappeared in 35 of 36 eyes examined at the 12th month. Visual improvement was statistically significant (P < .0001, paired t test). CONCLUSION: In eyes with diffuse diabetic macular edema and without posterior vitreous detachment, vitrectomy with posterior vitreous detachment may be effective.

Adult↗
PubMed1996

[Incidence of lack of posterior vitreous detachment in retinal detachment caused by flap tear in the elderly].

I investigated whether posterior vitreous detachment is invariably associated with retinal detachment in the elderly caused by flap retinal tears. Of 97 eyes which underwent vitrectomy, Weiss' ring was not observed in 10 eyes during both the preoperative slit lamp microscope examination and the intraoperative surgical microscope observation. I proved by surgically detaching the posterior vitreous in 5 out of those 10 eyes that the posterior vitreous had not yet become detached before the operation. My results suggest that posterior vitreous detachment may not be associated with 5 to 10% of cases of retinal detachment caused by flap retinal tears.

Aged↗
PubMed1995

Clinical features of retinal detachment in the elderly.

We conducted a retrospective study of 636 eyes (624 patients, aged 65 years or more) to identify the clinical features of nontraumatic retinal detachment in the elderly. The incidence of retinal detachment due to a macular hole in our series (21%) was much higher than those described in previous reports, suggesting a racial difference between Japanese and Caucasian patients. Tractional tear was seen more commonly in patients of less advanced age. In addition, in our series of elderly patients, we demonstrated (1) a preponderance of retinal breaks in the upper temporal quadrant, (2) a high incidence of aphakic retinal detachment, (3) a preponderance of females to be affected and (4) broad detachment of the retina that involved the macula.

Age Distribution↗
PubMed1995

[Induction and properties of nitric oxide synthase in rat retinal pigment epithelial cells in culture].

UNLABELLED: We investigated the production of nitric oxide (NO) and nitric oxide synthase (NOS) by rat retinal pigment epithelial cells (RPE) in culture. METHODS: RPE was isolated from the eyes of 7-10 day-old rats and cultured in Dulbecco's modified Eagle medium with 10% fetal calf serum. NO2- concentration in the culture medium was determined with the Griess reaction. NOS was assayed by measuring 3H citrulline as the reaction product. RT-PCR was performed on the isolated RNA fractions from RPE. RESULTS: Rat RPE produced NOS with the combined stimulation of the bacterial endotoxin and cytokines including interferon gamma. PCR experiments showed that stimulated RPE expressed a gene product corresponding to inducible-type NOS. The enzyme required arginine, NADPH, and tetrahydrobiopterin for the reaction. The specific activity of the crude RPE extract was approximately 270 pmol/min/mg. CONCLUSION: Like bovine RPE, rat RPE produced NOS by the immunological stimulation. Induced NOS and the product NO may play important roles in inflammation of the eye.

Amino Acid Oxidoreductases↗
PubMed1995

[Anterior chamber inflammation after cataract intraocular lens surgery in postvitrectomy eyes].

We determined the anterior chamber inflammation by means of laser flaremetry after cataract intraocular lens surgery for the nuclear cataract that developed after vitrectomy. Cases (38 eyes of 36 patients) were divided into the following four groups according to their pathologies indicating vitrectomy; proliferative diabetic retinopathy (PDR, 14 eyes), idiopathic posterior vitreous membrane syndrome (PVMS, 9 eyes), rhegmatogenous retinal detachment (RRD, 8 eyes), and branch retinal vein occlusion (BRVO, 7 eyes). Mean intervals between the two surgeries were 31, 23, 27 and 18 months, respectively. Phacoemulsification and aspiration through the self-sealing sclerocorneal wound and intraocular lens implantation in the bag were performed. The mean flare count was already high before the cataract surgery in all groups. Postoperative course of mean flare count was an overlap of two waves, one (P1) with a peak on day 1 followed by rapid decrease and the other (P7) with a peak on day 7 followed by slow decrease. Peak values of P1 were higher than the day 1 value after cataract surgery without fundus pathology, and higher in PDR and BRVO groups than in PVMS and RRD groups. P7 was like that observed after vitrectomy and there was close similarity among the groups.

Aged↗
PubMed1995

[Results of macular hole surgery].

Macular hole surgery in 133 eyes of 128 patients resulted in anatomical success (closure and disappearance of the macular hole) in 79% (105 eyes) with the follow-up ranging from 3 to 36 months (8.1 +/- 5.5 months). The anatomical success was correlated with short estimated duration of symptoms, small size of the macular hole and lack of findings suggestive of a long-standing macular hole. Postoperative visual acuity in the anatomically successful cases was correlated with the preoperative visual acuity (positive correlation), the patient age (inverse correlation), and the estimated duration of symptoms (inverse correlation). After macular hole surgery on 63 eyes with 12 months or more in estimated duration of symptoms, 0.3 or more disc diameter in the size, 0.1 or more in preoperative visual acuity, and patient age of more than 70 years, anatomical success was obtained in 95% (60 eyes) and visual acuity of 1.0 or more in 22% (14 eyes), and 0.5 or more in 71% (45 eyes). These conditions, thus, are those indicating good anatomical and functional results.

Adult↗
PubMed1995

[Anterior chamber inflammation after vitrectomy in posterior vitreous membrane syndrome and phacoemulsification and intraocular lens implantation].

We studied the anterior chamber inflammation with a laser flaremeter after transvitreal membrane peeling surgery for posterior vitreous membrane syndrome and cataract intraocular lens surgery, through separate surgery and combined surgery. In 16 eyes with vitrectomy and membrane peeling, mean flare count had one peak of 11 photons/msec at postoperative days 5 through 7. In 10 eyes with phacoemulsification and aspiration with posterior chamber lens implantation, the mean flare count had two peaks of 11 photons/msec at postoperative day 1 and in postoperative week 2. In 25 eyes with combined surgery of vitrectomy and cataract intraocular lens surgery, the mean flare count was similar to the summation of that of each simple surgery. In these 25 eyes, in 9 eyes with sutures, the mean flare count had two peaks of 37 photons/msec at postoperative day 1 and 27 photons/msec at postoperative week 2, and in 16 eyes with self sealing wounds, the mean flare count had one peak of 22 photons/msec at postoperative week two. In 14 vitrectomized eyes with cataract-intraocular lens surgery, the mean flare count was as high as in combined surgery. In eyes with self sealing wounds, the flare count at postoperative day one was significantly lower than that of sutured eyes.

Adult↗
PubMed1994

[Combined pars plana vitrectomy, lens removal and intraocular lens implantation for complications of diabetic retinopathy. Surgical results in 120 cases].

We performed combined vitrectomy, lens removal and posterior chamber intraocular lens implantation for proliferative diabetic retinopathy in 120 eyes of 101 patients. Follow-up periods ranged from 3 to 63 months, with a mean of 17 months. Three lens removal methods were used: extracapsular cataract extraction (14 eyes), phacoemulsification and aspiration (49 eyes), and pars plana phacoemulsification (57 eyes). Preoperative rubeosis iridis or neovascular glaucoma was found in 21 eyes. Gas or temporary silicone oil tamponade was employed in 32 eyes. Surgical results were good, and the postoperative vision was finger counts or below only in 13 eyes. Thus the combined surgery proved to have no serious problems. Our results indicate two important points. (1) It is best to chose either of the following two methods for the lens surgery: phacoemulsification with continuous circular capsulorhexis, self sealing sclerocorneal incision, and in-the-bag fixation of the posterior chamber lens, or pars plana phacoemulsification leaving the anterior capsule, rub off and aspirating the lens epithelial cells, continuous circular capsulorhexis, and posterior chamber lens implantation in front of the anterior capsule from a self-sealing sclerocorneal wound. (2) It is mandatory to do complete vitrectomy and cut out the vitreous gels incarcerated in the sclerotomy site.

Adult↗
PubMed1994

[Objective evaluation of apparent accommodation of pseudophakic eyes].

In 23 (9 males and 14 females) pseudophakic eyes which had a biconvex type intraocular lens (IOL) implanted after cataract extraction, we objectively measured changes in the anterior chamber (AC) depth caused by axial movement of the IOL accompanying accommodation of the contralateral phakic fellow eye, using a Schimpflug slit image with an anterior eye segment image analysis system (Nidek, EAS-1000, Japan). In 114 phakic eyes of 57 persons as controls, AC depths accompanying accommodation from distances of 5 m to 30 cm and 10 cm decreased with increasing age. The decreased mean value of AC depth with accommodation from distances of 5 m to 30 cm was 0.17 mm in patients in their teens, 0.15 mm in patients in their 20 s, 0.10 mm in the 30 s, 0.06 mm in the 40 s, 0.05 mm in the 50 s, and 0.03 mm in the 60 s. The decrease of AC depth with accommodation at a distance of 10 cm was 0 in patients in their 60 s. In the pseudophakic eye changes in anterior chamber depth caused by focusing at short distances were less than 0.04 mm, and decreasing rate of anterior chamber depth (DRAC) was less than 1% in all the pseudophakic eyes. Movement of IOL on the optical axis was too subtle to account for apparent accommodation of the pseudophakic eye.

Accommodation, Ocular↗
PubMed1993

Epiretinal membrane of proliferative diabetic retinopathy: an immunohistochemical study.

Nineteen cases of epiretinal membrane (ERM) in proliferative diabetic retinopathy were studied using immunohistochemical methods. Antibodies against type I-IV collagen, fibronectin (FN), glial fibrillary acidic protein (GFAP), vimentin and the monoclonal antibody (MAB) against human Müller cells were used to examine the membranes. Type II collagen was found on one side of the ERMs in 95% of the cases. The other types of collagen, FN and vimentin were also identified in most cases. Müller cells (GFAP- and MAB-positive) were found in 2/19 cases (11%), and astrocytes (GFAP-positive but MAB-negative) were found in 10/19 cases (53%). These results suggest that type II collagen (vitreal collagen) may act as a scaffolding in the formation of ERMs and that glial elements of the ERMs consist mainly of astrocytes.

Adult↗
PubMed1993

[Prospective longitudinal studies on lens changes after vitrectomy--quantitative assessment by fluorophotometry and refractometry].

We prospectively evaluated lens changes after vitrectomy on 55 patients with vitreoretinal interface syndrome such as idiopathic epiretinal membrane, vitreomacular traction syndrome, and impending stages of idiopathic senile macular hole. Postoperative changes in crystalline lenses were assessed by fluorophotometric measurement of lens autofluorescence, measurement of refractive errors and biomicroscopic evaluation of progression of nuclear sclerosis. Examinations were repeated prior to surgery and at 1, 3, 6, and 12 months postoperatively. While autofluorescene and light transmittance of the lens were not affected by vitrectomy in patients less than 50 years old, older patients showed a significant increase of autofluorescence and decreased transmittance as early as 3 months after surgery. The refraction became myopic with time especially in the older patient group. Nuclear cataract was also found on biomicroscopic examination in the older patients as early as 1 month after surgery and progressed with time. The older the patients were, the more prominent those lens changes were.

Adult↗
PubMed1992

Intravitreal neovascular tissue of proliferative diabetic retinopathy: an immunohistochemical study.

Intravitreal neovascular tissue in 8 cases of proliferative diabetic retinopathy was investigated using immunohistochemical techniques. All 8 cases yielded positive immunoreactivity for type II collagen (vitreous collagen). The intravitreal neovascular tissue was classified into two groups (A or B), depending upon the distribution of type II collagen. In group A (3 cases), blood vessels were entirely surrounded by vitreous collagen, and in group B (5 cases), the vessels proliferated on one side of a mass of vitreous collagen. Type I and III collagens were distributed diffusely within the extracellular space of the tissue, whereas type IV collagen and fibronectin (FN) formed a basement membrane-like foundation for the newly formed vessels. Glial fibrillary acidic protein (GFAP)-immunoreactive cells were not clearly detected in any of the cases. Neovascular tissue typically proliferated on the posterior vitreous surface (as found in group B), but was also found to penetrate the vitreous gel (as found in group A). As neovascular tissue proliferation proceeded, types I, III and IV collagens and FN were produced. Glial cells (GFAP-positive cells) were not essential for neovascular tissue formation.

Animals↗
PubMed1992

Surgical techniques and visual prognosis in retinal detachment due to macular hole.

In 250 eyes with retinal detachment due to macular hole, the visual prognosis of each surgical technique was evaluated. (1) Macular diathermy adversely affected the visual prognosis. (2) Macular buckling+macular diathermy produced a poorer visual prognosis than macular buckling alone. (3) The visual prognosis resulting from gas tamponade alone or vitrectomy+gas tamponade was better than that resulting from macular diathermy. It is not clear whether there is a significant difference in visual prognosis between gas tamponade alone and vitrectomy+gas tamponade. (4) Macular laser photocoagulation does not adversely affect the visual prognosis. Judging from these results, gas tamponade, which has the possibility of better visual prognosis and less operation stress, should be selected as the initial technique.

Electrocoagulation↗