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N Ota

Publications and source records attributed to N Ota.

At least 55 records · Page 3Linked to original sources
PubMed1990

Inorganic chemical approaches to pharmacognosy. VII. X-ray fluorescence spectrometric studies on the inorganic constituents of crude drugs. (5). The relationship between inorganic constituents of plants and the soils on which they are grown.

Inorganic constituents of the leaves of several kinds of plants growing on different soil types were investigated using energy-dispersive X-ray fluorescence spectrometry. The results can be summarized as follows: (1) Each plant exhibited a characteristic metals profile, even if they were grown on similar soil types. (2) As we would expect, the metals profile of the plant leaves depends on the inorganic constitution of the soil on which it is grown. However, the degree of the influence of the soil types on the metals profile of the plant differs according to the kind of inorganic element: Ca and Cu are almost independent of the soil types, but the Ti and Fe content is dependent upon the soil types. (3) Sr content of plant leaves is closely related to the ratio of Sr to Ca of the soil on which the plants are grown. (4) This information should be helpful in identifying the producing district or original plant of a crude drug by its metals profile.

Japan↗
PubMed1990

Inorganic chemical approaches to pharmacognosy. VIII. Determination of selenium in crude drugs by energy-dispersive X-ray fluorescence spectrometry.

Energy-dispersive X-ray fluorescence spectrometry following sample decomposition and preconcentration was developed to determine selenium in crude drugs. Samples were decomposed with conc. HNO3 and conc. H2SO4 in a flask with a reflux condenser. Evaporation of HNO3 had to be avoided to prevent serious loss of this element. Selenium was preconcentrated from the digestion liquid by two-step reduction with 4M HCl and ascorbic acid, the elemental selenium formed was adsorbed on activated carbon and then collected on a Nuclepore membrane filter for direct irradiation in an X-ray spectrometer. This analytical method (detection limit, 0.03 ppm) was used to determine selenium in many kinds of crude drugs. The analytical results indicated vegetable drugs to be low in selenium content: more than 0.5 ppm in only a limited number of samples and less than detection limit (0.03 ppm) in nearly all the samples. Animal drugs contain selenium at higher levels, Lumbricus and Cantharis being 7.46 and 1.67 ppm, respectively.

Plant Extracts↗
PubMed1990

Inorganic chemical approaches to pharmacognosy. V. X-ray fluorescence spectrometric studies on the inorganic constituents of crude drugs. (3). On the cinnamomi cortex.

Inorganic constituents of many Cinnamomi Cortices (64 samples; almost all obtained commercially on the Osaka market) were investigated using energy-dispersive X-ray fluorescence spectrometry. The results can be summarized as follows: (1) The Cinnamomi Cortex contains K, Ca, and Fe (except for Japanese cinnamon) at lower levels than those of orchard leaves, while Mn and Sr are present at high levels. (2) A feature of the metals profile of Cinnamomi Cortex is high Mn-content. Especially, Chinese cinnamon (originated from Cinnamomum cassia) contains at extremely high levels, 300-900 ppm, whereas Mn concentrations of Java and Japanese cinnamons range from 100 to 300 ppm, and those of Ceylon cinnamon ranged from 50 to 150 ppm. (3) The contents of Mn and Rb depend on the kind of Cinnamomi Cortex, making identification possible.

Cinnamomum zeylanicum↗
PubMed1989

Study of stomach cancer in atomic bomb survivors. Report 1. Histological findings and prognosis.

For the purpose of studying the histological findings and prognosis of stomach cancer in atomic bomb survivors, a histological diagnosis of 600 cases of stomach cancer observed between 1964 and 1986 in three medical institutions in Hiroshima City was made by a single pathologist and, furthermore, analysis of 231 cases thereof was performed using the DS86 dose estimated by the Radiation Effects Research Foundation. 1) By histological type of stomach cancer, the frequency of poorly differentiated adenocarcinoma (poorly differentiated adenocarcinoma and signet ring cell carcinoma) was significantly higher in the 1 rad or more group (average stomach organ dose of 30.6 rad) than in the 0 rad group. 2) As for stromal type, the frequency of scirrhous type was significantly higher in the 1 rad or more group, but no difference in infiltrative behavior could be demonstrated. 3) Early cancer tended to be observed at a low rate in the 1 rad or more group. 4) As for average survival time, of the early cancers only well differentiated adenocarcinoma showed a significantly lower survival time in the 1 rad or more group when compared to the 0 rad group.

Adenocarcinoma↗
PubMed1988

Hepatocellular pseudotumour (regenerating nodule) in the cirrhotic liver mimicking hepatocellular carcinoma.

During a recent 6-year period we have encountered 10 patients with 'hepatocellular pseudotumour in the cirrhotic liver' (regenerating hyperplastic nodule). The patients were all male, aged 40-82 years. Seven were chronic alcohol consumers. None was positive for HBs-Ag but seven had either anti-HBs or anti-HBc. Serum AFP level ranged from 4 to 28 ng/ml in six patients who did not have hepatocellular carcinoma at the time of the diagnosis of the pseudotumour. The lesions were depicted by ultrasonography in seven, by computed tomography in two, and by angiography in one case. Liver scan was negative in all five cases investigated. The pre-operative diagnosis was definitely or highly suspicious of hepatocellular carcinoma in three, of pseudotumour in the cirrhotic liver in three, and of recurrent carcinoma in one. In another three patients, pseudotumour was coincidentally discovered in resected specimens with hepatocellular carcinoma. The histopathological and follow-up studies demonstrated synchronous or metachronous development of carcinoma in seven patients. Whether or not these lesions in the cirrhotic liver are premalignant remains to be elucidated.

Carcinoma, Hepatocellular↗
PubMed1988

Ultrasonographic features of hepatocellular pseudotumour in the cirrhotic liver.

Eight cases of hepatocellular pseudotumours (HPT) were encountered in 6 years during which time 140 hepatectomies were performed for hepatocellular carcinoma (HCC). All were found during screening of cirrhotic patients. The ultrasonographic pattern of HPT was similar to that of HCC and their correct diagnosis was impossible by ultrasonography alone. A space-occupying lesion in the cirrhotic liver which is detected by ultrasonography but not by computed tomography and angiography may be a hepatocellular pseudotumour. This diagnosis is particularly likely if the serum alpha-fetoprotein level is normal.

Adult↗
PubMed1987

Appraisal of hepatic resection in the treatment of minute hepatocellular carcinoma associated with liver cirrhosis.

During the last 6 years, 205 patients with primary hepatocellular carcinoma (HCC) were admitted to our surgical departments. Thirty-eight had HCC smaller than 3 cm in diameter. There were 34 men and 4 women with an average age of 56.5 years. All patients had underlying hepatic disease: liver cirrhosis in 35 patients and chronic active hepatitis with fibrosis in the remaining 3. Pre-operative complications included: oesophageal varices in ten, cholelithiasis in five, peptic ulcer in two, gastric cancer in one, and severe hypersplenism in one instance. A radical resection was performed in 32 cases and palliative resection in 6. Simultaneous operations were carried out for the above mentioned associated conditions: distal splenorenal shunt in six, Hassab's devascularization procedure in one, splenectomy in one, cholecystectomy in four, cholecystolithotomy in one, and partial gastrectomy in one. Four patients had postoperative complications: liver failure, rebleeding, right haemothorax, and upper gastrointestinal bleeding from acute mucosal lesion of the stomach. One patient with liver failure died in coma within 1 month. The operative and in-hospital mortality rates were 2.6 and 7.9 per cent, respectively. Survival rates during the first 4 years in 32 patients with radical hepatic resection were 89.9, 67.2, 58.8, and 58.8 per cent, respectively. We suggest that hepatic resection should be the first choice of treatment for minute HCC even in the presence of liver cirrhosis.

Adult↗
PubMed1987

[Operative fiberoptic nephroureteroscope--removal of renal and upper ureteral stones].

Two types of operative fiberoptic nephroureteroscopes were developed with the cooperation of the Olympus Optical Company mainly to remove the upper urinary tract calculi. Removal of the renal and upper ureteral stones was attempted in nine cases. The ureter was dilated with olive tip, balloon and Teflon dilators alone or in combination. The combination of balloon and Teflon dilators seemed the most promising. As a result of ureteral dilation, operative fiberoptic nephroureteroscopes, 4.5 mm and 3.5 mm in diameter, could be passed into the ureter in all the cases and the stones could be visualized clearly. Four of the 7 upper ureteral stones and 1 of the 2 pelvic stones could be removed. The success ratio was 56%. The method of stone removal still requires improvement. At present, application of the operative fiberoptic nephroureteroscope is indicated for upper ureteral and renal stones less than 1.0 cm in diameter. With the improved techniques of stone removal using this fiberscope, the indications of extracorporeal shock-wave lithotripsy or percutaneous nephrolithotripsy will probably be greatly reduced in the near future.

Adult↗