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Biomedical subjects

N P Bekhtereva

Publications and source records attributed to N P Bekhtereva.

At least 19 recordsLinked to original sources
PubMed1990

[Transplantation of embryonal nerve tissues in the treatment of Parkinson disease].

The authors describe the results of experimental studies of transplants of embryonal nervous tissues of man in the brain of adult animals. Base the use of transplantation of the embryonal dopaminergic structures for the treatment of patients suffering from parkinsonism. Provide the first results of the treatment of 2 patients suffering from parkinsonism by means of transplanting parts of the medium cerebral vesicle of human embryos. The observation period amounts to 6 months.

Animals↗
PubMed1990

[The Institute of Experimental Medicine: the past, present and future].

The article dwells on the setting up in 1890 of the first Russian research biomedical institution, the Imperial Institute of Experimental Medicine, in St. Petersburg. It offers a concise layout of the basic stages of the Institute development till 1917, during the first years of the Soviet State formation, and in the period when the All-Union Institute of Experimental Medicine was established on the basis of the Institute of Experimental Medicine. Much is devoted to the development of the Institute of Experimental Medicine within the system of the USSR Academy of Medical Sciences (1945-1990) as well as to the prospects of modern physiological, biological, and medical research conducted in it.

Academies and Institutes↗
PubMed1984

[Neurochemical aspects of therapeutic electric stimulation].

Comparative analysis of the CSF and blood protein-peptide composition in Parkinsonian patients performed with the aid of indwelled electrodes prior to and after therapeutic electrical stimulation (TES) of the brain subcortical structures, revealed a therapeutic effect in the form of reduced muscular rigidity and a mental activation with a positive emotional response. After the TES the protein content in the biological fluids tended to become normalized and the the range of low-molecular protein-peptide fractions changed. A high-performance liquid chromatography, bidimensional electrophoresis and thin-layer chromatography revealed about 5-6 factors of peptide nature with the molecular mass less than 5000 daltons in the CSF and blood after the TES. These factors were shown to exert a biological effect upon muscle preparation of the leech.

Blood Proteins↗
PubMed1984

[Reflection of the semantic characteristics of the thinking process in the impulse activity of neurons].

The paper deals with the progress in research into the problem of reflection of semantic characteristics of psychological tests in impulse activity of neurons and neuronal assemblies. The high dynamicity of brain correlates of thinking in most brain zones is stressed. Advantages and limits of different technical approaches as well as the most urgent tasks to be solved are discussed.

Brain↗
PubMed1984

[Relationships of distantly located neuronal populations in the human brain in the realization of the thinking process].

The time characteristics of the interneuronal connections as well as interrelationships among distant neuronal populations of the human brain deep structures were studied during monotonous mental activity. It was shown that stable interrelationships could be considered as a correlate of mental activity though the connections themselves were not of the correlative nature. These connections, being the elements of the activity--maintaining system, could be of various degree of rigidity.

Brain↗
PubMed1980

[Bioelectric correlates of the brain's protective mechanisms].

The author substantiates the necessity of searching for new means producing a therapeutic effect on the brain of epileptic patients that would be similar, in principle, to the brain's own protective mechanisms. This can be done, in the author's opinion, on the basis of studying the most probable bioelectric equivalents of the protective mechanisms. The author suggests a new method for suppressing the epileptogenic focus. This suppression, close to the physiological one, is effected by applying a weak sinusoidal current to the focus via intracerebrally implanted electrodes. Data on the suppression of the epileptiform activity within the zone of the current application, as well as data confirming the local character of the current action are presented. The place of the new method in the system of complex therapy, particularly of epilepsy, is determined with consideration of the role of the stable pathological state. Probable neurophysiological mechanisms of the sinusoidal current action on the epileptogenic focus are discussed.

Amygdala↗