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Biomedical subjects

N P Dmitrieva

Publications and source records attributed to N P Dmitrieva.

At least 19 recordsLinked to original sources
PubMed2004

[Efficacy of multifactorial preventive interventions in achievement of target levels of low density lipoprotein cholesterol in survivors of myocardial infarction].

AIM: To assess Efficacy of multifactorial preventive Interventions in achievement of target levels of low density lipoprotein cholesterol in survivors of myocardial infarction. METHODS: Design of the study was open randomized comparative prospective. Two groups of patients with history of myocardial infarction were formed ("active intervention", n=88, "observation", n=48) and followed for 12 months. All interventions consisted in recommendatory and expository measures. Achievement of target low density lipoprotein cholesterol (LDLCH) levels, modifiable risk factors, blood lipids spectrum were assessed in 2-3, 5-6 and 12 months of observation. RESULTS: Overall effect of undertaken multifactorial intervention on modifiable risk factors was positive. By the end of the period of observation number of risk factors per patient decreased from 3.8+/-0.99 to 2.8+/-1.29 (p<0.05). However target levels parameters in many cases were not reached. About half of patients could not decrease consumption of saturated fats and cholesterol, nearly 25% continued to smoke. More than 55% maintained excessive weight and 64% had abdominal obesity. Among patients of "observation" group only 5 (4.2%) began to take lipid lowering drugs. In active intervention group average LDLCH lowering was 23%, 38% of patients received lipid lowering drugs and 44% (of those who completed the study) achieved target LDLCH levels.

Achievement↗
PubMed1979

[Changes in the thyroid gland in Itsenko-Cushing's disease and corticosteroma].

Histological and ultrastructural examinations and stereological analysis of the thyroid gland of 16 patients with Itsenko--Cushing disease and corticosteroma with glucocorticoid hyperproduction showed signs of a decrease in its functional activity. An increase in the colloid mass in follicles was accompanied by its irregular staining, flattening of the epithelium, lipomatosis of the stroma and ultrastructural signs of low activity of thyreocytes. The assumption of a spherical shape of the follicles was shown to be unjustified. The accurate quantitative evaluation of the structural changes in the thyroid gland requires information on the spacial organization of its components and shape of individual follicles.

Adrenal Rest Tumor↗
PubMed1978

[Histologic and ultrastructural features of human parathyroid cancer].

Histological and electron microscopic examinations of cancer of the human parathyroid gland showed different histological variants of cancer from dark chief cells to be characterized by polymorphism of the size and shape of the cells, atypical nuclei, a decreased number of organelles, increase of their polymorphism, appearance of centrioles with satellites typical of rapidly proliferating cells. Acidophilic cells of a solid variant of cancer were characterized by polymorphism of the size and shape, and the presence of a large number of mitochondria with osmiophilic or clear matrix and polymorphic cristae. All histological variants of cancer of the parathyroid gland have foci of necrosis, invasion of tumor cells into the gland capsule, and into the blood and lymph vessels.

Adolescent↗
PubMed1977

[Electron-cytochemical and morphometric study of the activity of several enzymes in thyrocyte metochondria during malignant degeneration].

Cytochrome oxidase and succinic dehydrogenase activities were studied in the mitochondria of rat thyroid cell during experimental malignization by means of the electron-cytochemical and morphometric methods. The activity of these enzymes in the mitochondria changed depending on the stage of malignization: at the early stages it approached the normal activity, and at the later stages (precancer)--it decreased and approached the mitochondrial activity of cancer cells. A sharp decrease in the activity of the enzymes under study in the morphologically changed mitochondria of cancer cells may characterize their qualitative changes.

Animals↗
PubMed1977

[Electron microscopic and morphometric study of the cellular composition of several forms of goiter in man].

According to the ultrastructural patterns four varieties of follicular cells are recognized in the cell population of the human goiter. The parenchyma of different goiters is composed of the same cell types and varieties. Goiters differ in percentages of these cells. The ultrastructure of the main cell form is correlated with the functional activity of the goiter. The "map" of cell composition of some forms of goiter is given, which may be used for a more exact diagnosis of the goiter, especially in the cases of discrepancy between the light microscopical morphological data and clinical picture of the desease.

Adult↗
PubMed1977

[Ultrastructural localization of thyrocyte acid phosphatase in the presence of thyrocyte hyperfunction in rats].

Acid phosphatase was found by electron microscopy in the lysosomes which appeared in great numbers in the follicular cells of rat hyperplastic thyroid gland. The other types of granules (mature secretory granules and lipids) whose amounts were also greatly increased in cases of functional thyrocyte strain were also nonreactive. The lysosomes were subdivided into three main groups according to distribution of the reaction product: the lysosomes with dense homogeneous deposit and with deposit in the form of densely or loosely packed dark round granules. The lysosome heterogeneity was apparently connected with their different functions also found within the colloid droplets in the form of inclusions of rarely located dark granules. The authors believe such granules to be the result of the merging of the colloid droplets and lysosomes. The acid phosphatase of the latter participated in the hydrolysis of the product of cell secretion with the formation of active substances.

Acid Phosphatase↗
PubMed1976

[Morphologic changes in the parathyroid glands in primary hyperparathyroidism].

On the basis of studies of the histological structure of 7 parathyreoadenomas removed in connection with primary hyperparathyroidism three types of their structure (trabecular, acinose, and solid) were singled out. As to their cellular composition, the adenomas could be divided into clear-cell and dark-cell adenomas (of main cells), oxyphilic adenomas, and adenomas of C-cells. The same cells (predominantly main clear cells) were found in the 9 studied hyperplastic parathyroid glands. Certain differences between the ultrastructure of cells of parathyreoadenomas and that of the hyperplastic parathyroid glands were established.

Adenoma↗