PubMed Health⌕ Search

Biomedical subjects

N P Fadeev

Publications and source records attributed to N P Fadeev.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Study of the tropism of sodium Selenium-75-selenite to experimental cancer of the mammary gland].

On 25 rats with DMBA induced mammary gland adenocarcinoma, there was shown the capacity of a tumoritropic labelled preparation sodium selenium-75-selenite be be absorbed by tumors in the amounts exceeding those in the adjacent muscle days after the administration. A coefficient of the differential accumulation characterizing the level of the isotope uptake by a tumor during the whole period of observation was 3--4. First, there was shown the possibility to use the model of mammary gland tumors induced by DMBA to test labelled tumoritropic compounds.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1979

[Radioisotope topical diagnosis of malignant lymphomas using gallium-67 citrate].

The diagnostic value of Ga-67 citrate scintigraphy was estimated based on the comparison of clinical and roentgenological findings, including lymphography, in 46 patients with lymphogranulomatosis and other malignant lymphomas. The results obtained indicated that scintigraphy with Ga-67 citrate is a valuable adjunct for diagnosing malignant lymphomas and lymphogranulomatosis in previously untreated patients and in the recurrences.

Adult↗
PubMed1979

[Tropism of radiopharmacologic preparations in lymphogramulomatosis in mice].

In experiments on 75 female mice of line SJL/J with lymphograulomatosis, 75 female mice of the same line without lymphogranulomatosis and intact non-lineal mice, the authors have studied the labelled tumorigenic compounds: indium-111, gallium-67-citrates and sodium selenium-75-selenite. It was found that only sodium selenium-75-selenite possesses an enhanced ability to be accumulated in lymphogranulomatosis involved lymph nodes in mice. Whereas indium-111 and gallium-67-citrates contrary to the literature data available showed no enhanced tropism to lymph nodes of mice with lymphogranulomatosis.

Animals↗
PubMed1978

[Adaptational and thyroid homeostasis and the state of fat and carbohydrate metabolism in lung cancer].

An examination of over 100 patients with cancer and benign processes in the lung has demonstrated that the increased hypothalamic threshold to homeostatic inhibition in the adaptation system and a tendency to lowering of this threshold in the thyroid system are typical for lung cancer patients. Disturbances of the carbohydrate metabolism are more frequently observed in lung cancer than lipid metabolism disorders, recognized in approximately 1/5 of all patients. Whereas lipid metabolism disorders in lung cancer patients are more closely than those of carbohydrate metabolism correlated with the state of adaptation and thyroid homeostasis. The data obtained will be compared with the results of the corresponding observations in patients with mammary gland cancer.

Adaptation, Physiological↗
PubMed1977

[Positive scintigraphy in the diagnosis of lung cancer].

Based on the clinico-morphological estimation of scannograms, performed by means of sodium selenite--selenium-75, chloromercury-197 and gallium citrate-67 in 231 patients with tumor (185) and nontumor (46) lung diseases, it was found that the best results were obtained in scannographic visualization of primary tumors of the lung (87%). Positive scintigraphy was found to be of high diagnostic value in recognition of lung cancer proceeding against the background of atelectasis, inflammatory processes and other "disguises" hampering the clinico-roentgenological diagnosis. Positive scintigraphy may be employed in establishing the differential diagnosis between malignant and benign lung tumors.

Adult↗
PubMed1976

[Radioisotope gastroscintigraphy in diagnosis of tumor and pretumor diseases of the stomach].

The results of isotope gastroscintigraphy, performed in 160 patients with tumor and pretumor diseases of the stomach, are reported. Based on a clinico-morphological estimation of gastroscintigraphic findings, it was found that in 115 (72%) patients the data of scanning coincided with the ultimate diagnosis. In 25 (16%) patients pseudopositive and in 20 (12%)--pseudonegative scannograms were obtained. The greatest number of pseudonegative results was noted in patients with gastric cancer (in 19 of 20), in 10 of them tumor being located in the cardiac portion of the stomach. The precision of diagnosing tumors in other anatomical portion of the stomach was 90%. In patients with pretumor lesions the character of scannographic alterations was dependent on the rate of impairment of gastric mucosa function and structure.

Adult↗
PubMed1976

[Study of gallium-67 citrate distribution in rat tumors].

In rats with transplantable tumors of different histological structure the authors have studied the dynamics of gallium-67 citrate distribution in tumors, adjacent tissues and blood. It has been found that gallium-67 is able to be accumulated in increased amounts in all tumors irrespective of their histological type. Tumor image in scannograms was mostly distinct on the 2--3d day after injection of gallium-67 citrate, when there was the greatest difference in accumulation of the isotope in the tumor and surrounding "intact" tissues.

Animals↗
PubMed1976

[Changes of peripheral blood flow in patients with cancer of the lungs, esophagus and cardia under the effect of anesthesia and surgery].

The authors report the data on changes in peripheral circulation, depending on the kind of anesthesia, the amount of operative blood loss, alterations in circulating blood volume and localization of tumor in patients with cancer of the lung, esophagus and cardia. Totally, 35 patients (15--lung cancer, 10--esophageal cancer, 10--cancer of the cardia) were explored. In 25 cases fluothane was used as the main anesthetic, in 10--neuroleptanalgesia. The state of peripheral circulation was estimated by the period semielimination of radioactive xenon-133 from the muscle depot. It was found that alterations in peripheral circulation were not dependent on tumor localization, the use of fluothane and neuroleptanalgesia is associated with similar changes in peripheral blood flow and, finely, an increased loss of blood results in more pronounced alterations in peripheral circulation.

Aged↗
PubMed1976

[Angioscanning in the diagnosis of breast neoplasms].

Angioscanning with macroalbumin J131 was performed in 30 patients with different mammary gland diseases (breast cancer--in 22, breast sarcoma--in 1, cystic fibroadenomatosis--in 6 and one patients without any breast pathology). Twenty eight of thirty patients were subjected to surgery, and the diagnosis was supported histologically. Injection of macroalbumin J131 in the subclavian artery enabled the authors to visualize malignant neoplasms, located mainly in the external quadrants of the mammary gland. The least size of the tumor, revealed by angioscanning, was 1.5 cm in diameter. The method of isotope injection directly in the subclavian artery, employed by the authors, may be recommended for patients, whose primary tumor is localized in the external half of the gland and in the axillary process.

Adenofibroma↗