Biomedical subjects

N P Macri

Publications and source records attributed to N P Macri.

5 recordsLinked to original sources

PubMed1997

Salmonella arizonae sepsis in a lynx.

A 4.5-wk-old lynx (Felis lynx) was presented for necropsy with a history of poor growth, mild diarrhea, anemia, and lethargy. The liver was enlarged and had a 7 mm long fracture that resulted in severe intraabdominal hemorrhage and death. Microscopic lesions were indicative of severe ulcerative cystitis and septicemia. Pure cultures of Salmonella arizonae were isolated from the liver, kidney, and spleen. Based on differences in the chronicity of inflammation in the urinary bladder versus other organs, we speculate that chronic cystitis caused by S arizonae lead to septicemic infection.

Animals↗

PubMedDate not supplied

Canine spinal nephroblastoma.

An eight-month-old, female, mixed-breed dog was presented with bilateral hind-limb paralysis that reportedly developed over a two-to-three week period and was not associated with trauma. Plain radiographs of the spinal column were unremarkable, and a myelogram outlined an intramedullary mass of the spinal cord at the first lumbar (L1) vertebra. A hemilaminectomy was performed, and a mass that was identified histologically as nephroblastoma was excised from the spinal cord. Following surgery, the dog became fully ambulatory, and at 22 months postsurgery she remains clinically normal. The diagnosis, treatment, progression, histogenesis, and pathology of canine nephroblastoma are discussed.

Animals↗

PubMedDate not supplied

Microbiological analysis of the early Salmonella enteritidis infection in molted and unmolted hens.

A study was conducted in which the early kinetics (4 hr to 96 hr) of an infection by Salmonella enteritidis in older white leghorn hens was examined, and a molt was induced through withholding feed to determine its effect on the progression of this infection. Molted and unmolted hens were orally infected with 5-10 x 10(6) S. enteritidis on day 4 of the feed removal. At 4, 24, 48, 72, and 96 hr postinfection, liver, spleen, ileum, colon, cecum, and feces were removed from six hens per group and sampled for the presence of the challenge organism. By 24 hr postinfection, S. enteritidis was most prevalent in the cecum and feces of unmolted hens, and this prevalence continued throughout the experimental period. In molted hens, however, S. enteritidis could be detected in a high percentage (90-100%) of colon, cecum, and feces samples at 24 to 96 hr postinfection and in 67% or more of ileum samples at 48 to 96 hr postinfection, indicating a much wider distribution of the S. enteritidis along the intestinal tract than in unmolted hens. The numbers of S. enteritidis recovered from these alimentary samples were also significantly higher in molted than unmolted hens. S. enteritidis could not be detected in livers or spleens of either treatment group at 4 or 24 hr postinfection. At 48, 72, and 96 hr postinfection, 50% or more of the livers and spleens in both the molted and unmolted hens were positive for the challenge organism, but significantly more S. enteritidis was recovered from the organs of the molted hens at these three sampling times.(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗

PubMedDate not supplied

The effects of induced molting on the severity of acute intestinal inflammation caused by Salmonella enteritidis.

This study describes and compares early inflammation caused by Salmonella enteritidis in molted and nonmolted hens. Adult white leghorn chickens were orally infected with Salmonella enteritidis 4 days after feed removal. At 2, 4, 8, 10, 24, 48, 72, and 96 hr after infection, the hens were euthanatized, and the duodenum, jejunum, ileum, cecum, and colon were evaluated by light microscopy. Two trials were conducted, and in both trials inflammation occurred more frequently and was significantly greater in the cecum and colon of molted-infected hens compared with nonmolted-infected hens beginning at 8 hr after infection. In one trial, inflammation was more severe in the ileum of molted-infected hens compared with nonmolted-infected hens. Results indicated that molting by feed deprivation shortened the time of onset and increased the severity of acute intestinal inflammation caused by Salmonella enteritidis.

Animals↗

PubMedDate not supplied

Microsphere uptake by the intestine of White Leghorn chickens.

A study was conducted to determine the effective size for latex microsphere uptake in the intestine of white leghorn chickens. Three trials were conducted in which ligated intestinal segments of anesthetized 8-wk-old chickens were injected with 0.2-, 0.5-, 2-, 6-, 10-, or 20-mu diameter fluoresceinated latex microspheres. Microspheres were counted in brush border, epithelium, and lamina propria of each intestinal segment, liver, and spleen. After 1 hr, the 0.2-, 0.5-, and 2-mu microspheres were oriented along the brush border of epithelial cells and microsphere uptake into the epithelium and lamina propria was observed in the duodenum, ileum, cecum, cecal tonsil, and colon. Uptake of microspheres of 6, 10, and 20 mu diameter into epithelium and lamina propria was not observed in any intestinal segment. Also, no microspheres of any diameter were observed in sections of liver and spleen to suggest that there was no appreciable entry of microspheres into the bloodstream within 1 hr after administration. The results indicated that uptake of microspheres by the chicken intestine is a size-dependent process with microspheres < or = 2 mu being taken up to an equal extent by most segments of intestine.

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