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Biomedical subjects

N P Moskalenko

Publications and source records attributed to N P Moskalenko.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Effectiveness of nonachlazine in ischemic heart disease under ambulatory conditions].

The efficacy of nonachlazine given in a daily dose of 90--180 mg was studied in 82 out-patients with ischemic heart disease. The drug had no marked effect on the frequency of angina pectoris attacks and the number of times that nitroglycerin had to be taken; no essential changes were noted in the pulse rate and arterial pressure level. A certain increase in the tolerance to physical loan was found. The authors emphasize that in evaluating the effect of a drug on ischemic heart disease, it is necessary to take into account the cyclic course of the disease and the effect of nonmedicamentous factors (weather changes, temporary incapacity for work, etc). The authors do not confirm the conclusion of other researchers who claim that a daily dose of 90--180 mg of nonachlazine is highly effective.

Adult↗
PubMed1980

[ECG study of diabetes mellitus patients at rest, in an orthostatic posture and under physical load].

ECG changes at rest were noted in half of 87 patients with diabetes mellitus. Negative ECG changes in orthostatics were observed in 2/3 of the patients. The rate of the changes depends upon the heart rate increase, reflecting higher sympathetico-adrenal activity. The results of potassium salt application point to metabolic disorders in the myocardium of patients with diabetes mellitus. The orthostatic test performed during the course of treatment with potassium salt may serve as an index of efficiency and stability of the therapy conducted. ECG changes under physical exercise were observed in 14 of 54 patients, only in 4 of them the changes were tupical of coronary heart disease. Comparison of exercise tolerance, orthostatic and potassium salt tests which reveal cardiac damage of different nature, suggests that myocardial changes in patients with diabetes mellitus are mostly conditioned by the development of metabolic changes.

Coronary Disease↗
PubMed1977

[Pyridoxylate treatment of athletes with chronic myocardial overexertion].

Twenty-five highly skilled athletes with chronic stage I or II myocardial overexertion were examined. It was established that pyridoxilate produced a good therapeutic effect despite the fact that the athletes went on with their sport activities. On the background of the treatment the ECG and the indices of cardio- and hemodynamics and gas exchange improved and the physical efficiency grew. No essential difference was found in the effectiveness of pyridoxilate when it was administered by different routes. Side-effects of treatment were not observed.

Blood Pressure↗
PubMed1976

[Use of pyridoxylate for treating chronic coronary insufficiency].

A total of 49 patients with chronic ischaemic heart disease (38 of whom had previously survived myoca dial infarction) were treated with Piridoxylate administered intramuscularly and orally. The treatment resulted in an improvement of the state of 2/3 of the patients, positive ECG shifts, improvements of cardio- and haemodynamics at rest and under physical exercises. In half of the patients an increased tolerance of physical exercises was noted. No side-effects of Piridoxylate therapy were observed.

Administration, Oral↗
PubMed1976

[Presence of the blood depot in orthostatic position and after physical exertion].

In healthy individuals and in patients with essential hypertension in the orthostatic position and on physical effort an insignificant reduction in the volume of the circulating blood and of the packed cell volume were in evidence; this being due to the outflow of the liquid part of the blood into the tissues. Even in instances of a well-marked orthostatic hypotonia, during medication with sympatholytic agents in particular, the circulating blood volume in the orthostatic position does not show any significant change. The results obtained by the authors and an analysis of the published data suggest that all of the blood is in circulation with none of it being repository or leaving the depot either in the orthostatic position or on physical effort.

Antihypertensive Agents↗
PubMed1976

Effects of propranolol on haemodynamic changes and gas exchange at rest, in orthostasis, and on exercise in patients with arterial hypertension.

The effects of propranolol on the circulation and respiration were studied in 38 patients with essential hypertension and symptomatic renal hypertension. The hypotensive effect of propranolol was associated with decrease in the cardiac index and heart rate; the peripheral vascular resistance moderately increased, and the circulating blood volume and haematocrit value showed no essential changes. Besides, a prolongation of the pre-ejection period, the decrease of intrasystolic index, an increase in the myocardial wall-tension index, and a retardation of the elevation rate of the intraventricular pressure were observed. After propranolol medication, on transition into the vertical position the heart rate showed a less marked acceleration; the remaining haemodynamic parameters changed in orthostasis as they had done before the treatment. After propranolol medication, on exercise the systolic and mean arterial pressures, heart rate, and cardiac output exhibited lesser increases than before the treatment, whereas the circulating blood volume, diasolic pressure, and peripheral vascular resistance increased just as they had done before the treatment. At rest, during propranolol medication there appeared a certain tendency to decreased oxygen uptake; in orthostasis the degree of increase in oxygen uptake did not change by the action of propranolol. Besides, propranolol did not alter the blood-plasma levels of lactic acid and pyruvate at rest and did not essentially change the oxygen uptake during exercise. The level of lactic acid and the lactate/pyruvate quotient in plasma during exercise increased slightly less after than without propranolol.

Blood Volume↗
PubMed1975

[Effect of propranolol on hemodynamic shifts and respiration during physical exertion in patients with hypertensive disease].

An examination of 25 patients with hypertensive disease of the I-II stage proved that following propranolol treatment the systolic and mean arterial pressure, the rate of cardiac contractions and the minute blood volume accrue on physical effort to a lesser extent, and the circulation time, diastolic pressure and peripheral resistance ot the blood flow-to the same degree as before the medication. Changes in the phasic structure of the left ventricle of the heart in physical exertion are less marked than they were prior to the treatment. Propranolol does not materially change the level of the oxygen consumption on effort; the lactic acid level and the ratio lactate/pyruvate in the blood rise against the background of the medication with this drug to a some-what lesser degree than before the treatment.

Blood Pressure↗
PubMed1975

[Use of gutimine for treatment of chronic coronary insufficiency].

The therapeutic effect of an antihypoxic drug--Gutimine--was studied in 30 patients with chronic coronary insufficiency. The effect of gutimine on the adaptation for physical exercises connected with motor hypoxy in 5 normal individuals was used as control. The treatment with Gutimine resulted in a clear subjective improvement (less frequent and less intense anginal attacks) in 2/3 of the patients with chronic coronary insufficiency. Objective signs of improvement (positive ECG shifts, phases of the left ventricular systole and hemodynamics; increased tolerance of physical exercises) after Gutimine therapy were noted only in 4 patients who had a comparatively mild course of their disease and less distinct sclerotic changes in the myocardium. When Gutimine was used in normals, significant improvement of their capacity for work was noted, as well as an improvement of their cardiovascular functions and gas exchange parameters during "extreme" exercises. The positive effect of Gutimine was more distinct after 1-2 weeks of its administration. Side effects were absent.

Adult↗
PubMed1975

[Changes in hemodynamics in patients with chronic alcholism].

The indices of total hamodynamics were studied in 52 patients with chronic alcoholism and without any clear signs of cardiac pathology and with normal arterial pressure. When examined at rest in a supine position they exhibited normal values of the cardiac and stroke index, peripheral vascular resistance, circulating blood volume and hematocrit. Along with the increasing period of alcohol abuse the cardiac index gets somewhat decreased, indicating a decreasing contractile capacity of the myocardium. This is further supported by the changing structure of the phases of the systole: prolongation of the phase of isometric contraction, of the tension phase, the tension index, reduction of the intrasystolic index and of the speed of intraventricular pressure increase. The orthostatic test revealed certain disorders in the regulation of the cardiovascular system in an upright position which manifested themselves in a more distinct, than in normal individuals, reduction of the cardiac and stroke indices, and in a more significant growth of cardiac contractions rate and peripheral vascular resistance. The latter indicates an increased mobilization of the sympathoadrenal system in an orthostatic position.

Adult↗