PubMed Health⌕ Search

Biomedical subjects

N P Nikolov

Publications and source records attributed to N P Nikolov.

9 recordsLinked to original sources
PubMed1984

[Whipple disease: clinical and immunohistologic findings in 2 cases].

Two cases with typical clinical and histological manifestations of Whipple's disease were reported. Peroral jejunal biopsies were studied in the florid stage and during remission achieved by tetracycline therapy. A complete absence of immunoglobulin-containing cells (Ig-CC) and an increased number of mast cells in the mucosa were established in one of the cases. A 5-fold decrease of the mucosal Ig-CC was found by immunofluorescent morphometry in the second case. An increased Ig-CC number and histological restitution of the mucosa were shown in the first case during remission, whereas histological alterations and decreased Ig-CC number persisted in the second case despite of clinical improvement. The HLA-locus B27 was not available in the reported cases.

Female↗
PubMed1984

[Correlation between immunoglobulin-secreting cells and secretory immunoglobulins in the small intestine in chronic intestinal diseases].

A total of 45 patients were studied: seven with gluten enteropathy and 38 with chronic unspecific enteritis. Histological and immunefluorescent studies were performed and to a part of the cases--enzymatic and electron-microscopic investigations of the jejunal mucosa. An increased number of immuneglobulin -secreting cells was established in the non-treated patients with gluten enteropathy, growing with age. In the cases with chronic unspecific enteritis with a manifested clinic, a tendency to decrease of the number of IgSC was observed, with growing percentage of IgG-SC and the values of the secretory IgG. There was no correlation between the intraepithelially located lymphocytes and those in the chorion, as well as between the duration of the disease, number and percentage distribution of Ig-SC.

Antibody-Producing Cells↗
PubMed1982

[Gluten enteropathy--epidemiologic, clinical, morphologic and enzymatic study].

The results from the clinical, morphological and enzymatic studies are reported upon the jejunal mucosa and the effect of a gluten-free diet among a group of 60 patients with gluten enteropathy and 5 patients with idiopathic steatorrhea. The significance of light microscopic and electronmicroscopic studies are discussed in details in making the diagnosis, differential diagnosis and assessment of the results from the treatment of gluten enteropathy.

Adult↗
PubMedDate not supplied

Methotrexate use in rheumatoid arthritis is associated with few clinically significant liver function test abnormalities.

OBJECTIVE: To determine the frequency of liver function tests (LFT) abnormalities associated with methotrexate (MTX) use in the treatment of rheumatoid arthritis (RA). METHODS: A retrospective chart review for demographic information, RA-specific history, medication history, complications of therapy, results of all available blood tests (specifically aspartate aminotransferase (AST), alanine aminotransferase (ALT), complete blood count (CBC), albumin, creatinine), and liver biopsy reports was conducted for RA patients, who were currently using or have used MTX in the past. RESULTS: A total of 2791 LFTs were performed among 182 RA patients with 94 abnormal results. 152 patients (83.5%) with 2007 LFT evaluations demonstrated no abnormal results, compared with 30 patients (16.5%) who had at least one abnormal LFT in 784 tests. Twenty-two of the 30 patients with at least one LFT abnormality (73.3%) continued treatment despite the elevation without further evaluation or change in therapy, and subsequent LFT assessments were within normal limits. 128 patients (70.3%) remained on MTX at the time of our study. The most common reason for discontinuation was inadequate response. CONCLUSIONS: MTX appears to be associated with very few clinically significant hepatic side effects. In view of these data, consideration as to revision of the current MTX monitoring guidelines in the direction of less frequent monitoring, especially in patients with no risk factors for liver disease, may be considered.

Adolescent↗