The results of pharmacokinetic studies of chlodithane tablets hydrophilized with aerosil have shown that the maximum blood concentration of the drug is seen 6 hours after its administration. The most intensive chlodithane absorption by the gastrointestinal tract was noted after using single 1- and 2-g doses (94.9 and 90.8%, respectively). The drug excretion with feces with comparatively low when the daily dose of 4 to 8 g (15.9 to 25.9%) was used. The drug excretion rose to about 50% after the inhibitor dose was increased to over 8 g. It was found that 73.59 +/- 1.87% of the drug is absorbed by the gastrointestinal tract. Thus, it is recommended that chlodithane be administered in a dose of 1 to 2 g 30 minutes after meals with 3- to 4-hour intervals, the daily dose not exceeding 8 g. The recommended scheme provides sufficiently high drug absorption by the gastrointestinal tract and the constant inhibitor concentration in the blood.

Adolescent↗

PubMedDate not supplied

[Prospects for research into the mechanochemical processes in drug technology].

Explore the source record for details and available documents.

Chemical Phenomena↗

PubMedDate not supplied

[Biopharmaceutic study of medicinal forms of preparation K].

Explore the source record for details and available documents.

Administration, Topical↗