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Biomedical subjects

N P Rothgardt

Publications and source records attributed to N P Rothgardt.

7 recordsLinked to original sources
PubMed1990

Human listeriosis in Denmark 1981-1987 including an outbreak November 1985-March 1987.

Clinical manifestations, predisposing factors and outcome of listeriosis in Denmark during the period 1981-1987 are described. An increased incidence of the disease during the period November 1985-March 1987 was due mainly to 35 patients infected with strains of Listeria monocytogenes indistinguishable by phage-typing. These patients were younger, previously healthier and had a better prognosis. Also, there were more cases in pregnant women and neonates than in other persons. A strong correlation was found between predisposing factors and mortality. We conclude that there was an outbreak caused by a single source of infection and which was distributed all over the country. It lasted for more than a year and affected most categories of people. The source was not identified.

Adult↗
PubMed1989

The treatment of Listeria monocytogenes infections in the central nervous system.

Fifty-four cases of Listeria monocytogenes meningitis and meningoencephalitis occurred in Denmark between 1981 and 1986. The aim of the present study was to consider the antibiotic treatment of these patients, 33 males and 21 females aged from 16 months to 91 years: average (AV) 54 years. One or more predisposing factors (PF) were found in 30 patients (55%): steroid treatment (15), cancer (12), alcoholism and/or cirrhosis (10), diabetes mellitus (5), and renal allograft (2). Follow-up varied from 3 months to 5 years. Ampicillin (AMP) was used as the only antibiotic in 14 patients, and with an aminoglycoside (AMI) in 38 but AMI was withdrawn within 24-48 h in 14. High doses of AMP were used (AV 16 g/day) generally for two weeks (AV 11 days), but AMI was usually withdrawn in the first week (AV 5 days). The mortality rate (MR) was 39% and varied greatly between previously healthy patients (PHP) and those with one or more PF: only 2 out of 24 PHP died, both admitted to hospital with respiratory insufficiency and shock. No significant differences between survivors and non-survivors were observed either in the doses, duration and administration of AMP, or use of AMI, although a higher number of PF was found in the non-survivors. Relapse occurred in at least 3 immuno-compromised patients. Sequelae were reported in 9 patients. Death occurred in 6 within 24-48 h of admission. Delayed diagnosis and treatment together with the underlying disease seemed responsible for the high MR. More effective treatments in immunocompromised patients should be tried.

Adolescent↗
PubMed1989

The treatment of Listeria monocytogenes septicaemia.

Thirty cases of Listeria monocytogenes septicaemia occurred in Denmark between 1981 and 1986. The aim of this study was to consider the treatment of these patients, 18 males and 12 females aged from 20 to 87 years: average (AV) 65 years. One or more predisposing factors (PF) were found in 90% of the patients, mainly cancer (16), steroid treatment (12), cirrhosis and/or alcoholism (8), and diabetes mellitus (3). Follow-up varied from 3 months to 5 years. Ampicillin (AMP) alone or with an aminoglycoside (AMI) was the treatment in 9 and 16 cases, respectively. One patient was successfully treated with penicillin G and another received oral co-trimoxazol after recovered with carbenicillin plus AMI. AMP doses were lower than used in listerial meningitis (AV 5 g/day vs. 16 g/day), and the duration was variable: from one to 21 days (AV 8 days). The mortality rate was 50%. No significant differences between survivors and non-survivors were observed either in the antibiotic treatment (doses, duration, administration, and use of AMI), or the number and kind of PF found. The cause of septicaemia could not be established in most cases but 3 endocarditis, 2 perianal abscesses and one pericarditis were found in the non-survivors. Pulmonary involvement was present in 13 patients and CNS infection suspected in 10. Early diagnosis, adequate doses and duration of antibiotic treatment, and the use of drugs capable to penetrate purulent collections (microabscess and abscess formations) should improve the prognosis of L. monocytogenes septicaemia.

Adult↗
PubMed1980

Long-term treatment of hypertension with labetalol.

The effect of long-term treatment with labetalol was evaluated in an open clinical investigation in a total of 32 patients (15 women, 17 men), mean age 56 years (range 18-81 years). Labetalol was used in a mean daily dose of 1356 mg (range 400-3000 mg) either as mono-therapy or in combination with other drugs. Twenty-three patients were treated for more than six months, with a mean period of treatment of forty months. Thirteen of these 23 patients continue on treatment with a mean period of treatment of fifty-one months (range 6-65 months). This study does not lend support to the idea of tolerance developing to the effects of labetalol. There were no signs of liver, kidney or bone marrow involvement, and there were no changes in the retina. In 13 of the 32 patients the treatment was discontinued following subjective complaints possibly induced by the drug, partly orthostatic hypotension, and partly side effects probably related to the beta- adrenoceptor blocking effect of labetalol. Until the incidence of subjective side effects has been carefully evaluated labetalol will be used with reservations, especially as a first choice in the treatment of hypertension.

Adolescent↗