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Biomedical subjects

N P Südkamp

Publications and source records attributed to N P Südkamp.

At least 19 recordsLinked to original sources
PubMed2007

[Congenital radial head dislocation on both sides].

Both traumatic and congenital dislocation of the radial head are very rare in childhood. It can sometimes be difficult to tell them apart in practice. In this paper therefore, we present one case and discuss the various aspects of both conditions with reference to the available literature. Traumatic dislocation of the radial head is generally easily reduced without open surgery, and an open procedure is virtually never indicated in a patient who is still growing. In contrast, specific treatment of congenital radial head dislocation is not necessary because most patients are free of pain.

Bone Wires↗
PubMed2007

[The AO/ASIF Flexnail : A flexible intramedullary nail for the treatment of humeral shaft fractures].

BACKGROUND: The use of conventional implants for intramedullary nailing of humeral shaft fractures is associated with specific difficulties. During antegrade implantation structures of the rotator cuff can be affected leading to a reduced functional result of the shoulder. If the nail is implanted in a retrograde manner problems arise due to a relatively large hole close to or within the olecranon fossa, which is necessary for insertion of the nail. Supracondylar fractures as well as persistent elbow pain and loss of function are reported in the literature. To overcome these disadvantages a flexible nail has been developed that can be stiffened and locked after implantation. METHOD: Between October 2000 and February 2002, 34 patients were treated with the flexible nail at our institution; 29 were available for follow-up. Fracture healing was documented on radiographs and clinical outcome was evaluated with use of the Constant as well as the Kwasny score. RESULTS: Median duration until fracture consolidation was 10 weeks. In two patients fracture union was not achieved within the follow-up period. The median outcome measured with the Constant score was 93 points and 2.5 with the Kwasny score. Both values correspond to a very good functional outcome. CONCLUSION: We conclude that the flexible humeral nail is an excellent treatment option for humeral shaft fractures. Damage to the rotator cuff and the distal humerus can be avoided due to its unique flexible construction, improving the functional outcome of intramedullary nailing for the treatment of humeral shaft fractures.

Adolescent↗
PubMed2006

[Prehospital care of surgical emergencies].

Surgical emergencies embrace the fields of general and visceral surgery (e.g. unclear/acute abdomen, blunt abdominal trauma, perianal venous thrombosis), vascular surgery (e.g.: venous and arterial bleeding, aortic aneurysm), accident, hand and plastic surgery (e.g. dislocations, fractures, amputation injuries, penetrating injuries, burns, hypothermia, complicated trauma, thoracic trauma). The prehospital treatment options discussed in the present article represent the current state of the art.

Accidents↗
PubMed2006

[Rupture of the arteria subscapularis following reduction of an anterior shoulder dislocation].

Anterior shoulder dislocations are one of the most common problems seen in an emergency department. Doubtless, immediate reduction is necessary for treatment, a procedure that is extremely rarely accompanied by complications. In these cases early diagnosis and treatment may be limb saving. We report a case with rupture of the arteria subscapularis following reduction of an anterior shoulder dislocation with formation of an axillary hematoma and consecutive paresis of the plexus brachialis. Interdisciplinary operative revision was necessary to remove the hematoma, stop the hemorrhage and for neurolysis of the plexus brachialis. Treatment resulted in a speedy recovery of the patient. Gentle reduction of a dislocated shoulder is a prerequisite for a low complication rate. Contrast-enhanced computed tomography facilitated diagnosis of the hematoma and identification of the bleeding vessel.

Aged, 80 and over↗
PubMed2006

[Intertrochanteric femoral fractures in children].

Based on two cases and a review of the literature, we describe a rare injury in childhood, intertrochanteric femoral fracture. Because of the insertion and traction of muscles at the proximal femur, conservative treatment is difficult. The hip muscles pull the proximal fragment into flexion, abduction and external rotation. In our opinion, surgical stabilization is the therapy of choice. We use an angular stable, locking compression plate for the stabilization of these fractures. Postoperatively, mobilization with full weight bearing is possible.

Adolescent↗
PubMed2006

[Diagnosis and treatment of the Essex-Lopresti lesion. Literature review and four case reports].

BACKGROUND: A fracture of the radial head in combination with a rupture of the interosseous membrane and lesion of the distal radioulnar joint known as Essex-Lopresti lesion is a rare injury. Usually it is caused by a high-energy trauma. Initially unrecognized distal radioulnar dislocations often show poor results. MATERIAL AND METHOD: Four case reports are presented to discuss the trauma mechanism together with diagnostic and treatment options. Especially the accuracy of ultrasound to diagnose an interosseous membrane disruption was evaluated. RESULTS: After an average of 35 months all patients were examined using the Morrey score and the modified score of Green and O'Brien. Initially the extent of the injury was not diagnosed in three cases. According to the score values the average results have been fair. CONCLUSIONS: An early diagnosis is the key for the correct treatment of an Essex-Lopresti lesion based on the classification of Edwards and Jupiter. In addition to the clinical and radiological assessment ultrasound should be used to diminish the rate of unrecognized interosseous membrane disruptions.

Adult↗
PubMed2006

[Injuries of the cervical spine with Forestier's disease. Problems in the diagnostic and surgical management].

The incidence of diffuse idiopathic sceletal hyperostosis (DISH) is described in men more than 50 years old up to 25% and in women up to 15%. Even little trauma in patients with DISH often leads to injuries of the spine, especially the cervical spine. In many cases MRI is necessary to find the injury in this anatomically modified spine. It is often difficult to detect the injury by plane radiographs or even CT. Based on two cases of cervical spine fractures in patients with DISH we will describe the difficulties and specialities in the diagnostics and surgical treatment of injuries of the cervical spine in patients with DISH. In the one case we stabilized a patient with an odontoid fracture type Andersson II, the other case was a traumatic spondylolisthesis C4/C5. Both cases were treated operatively, the odontoid fracture was stabilized by a single screw, the spodylolisthesis by a ventral plate. If there are modifications in the spinal anatomy by degenerative diseases like DISH or spondylitis ankylosans, it is important to perform an intense search for injuries of the spine. In many cases MRI is indicated to detect the injury because plane radiographs and CT are not sensitive enough. For the planning of the operation it is important to meet concerns to the thick anterior longitudinal ligament and to use screws, that are long enough because the use of standard instruments is often not successful.

Aged, 80 and over↗
PubMed2006

[Injuries of the midfoot in children].

Midfoot injuries of children are rare entities and often caused by high energy trauma mechanisms. Foot fractures in children may pose a diagnostic challenge but they usually have a good prognosis. In special cases computed tomography is necessary to find the right diagnosis in addition to plain X-rays. Based on two cases of midfoot injuries, a type II open Lisfranc fracture dislocation and a dislocation of a Chopart's joint, we describe the causes, diagnosis, and possibilities for treatment of juvenile midfoot injuries.

Athletic Injuries↗
PubMed2006

[Clinical, radiological and arthroscopical aspects in nail patella syndrome. Literature review based on an affected family].

Nail patella syndrome (NPS) is an autosomal dominant hereditary disorder affecting the nails, skeletal system, kidneys, and eyes. Skeletal features include absent or hypoplastic patellae, patella dislocations, elbow abnormalities, talipes and iliac horns on plain films. The existing literature focuses on clinical and radiographic findings in patients with NPS. We also report the case of a 40-year-old male patient and his family affected by NPS and includes clinical, radiographic as well as arthroscopic findings. Arthroscopic findings in this case are characterized by multiple synovial plicae in the knee joint leading to cartilage defects on the corresponding cartilage surfaces. A review of the recent literature suggests that the occurrence of synovial plicae might be related to NPS and might account for at least part of the characteristic symptoms of these patients. Therefore, in cases of unspecific knee pain associated with NPS arthroscopy of the knee joints and plicae resection seems to be recommendable.

Adult↗
PubMed2006

Transplantation of mesenchymal stromal cells on mineralized collagen leads to ectopic matrix synthesis in vivo independently from prior in vitro differentiation.

BACKGROUND: Tissue engineering using mesenchymal stromal cells (MSC) represents a promising approach for bone regeneration. Nevertheless, the optimal constructs have yet to be determined. It still remains unclear if there is a benefit of in vitro differentiation of MSC prior to transplantation or if undifferentiated MSC hold the optimal potential concerning new tissue formation. METHODS: After isolation and in vitro expansion, MSC were seeded on mineralized collagen sponges and transplanted in a heterotopic SCID mice model (n=12). While group A contained undifferentiated MSC, in group B cells were cultivated for 14 days in vitro under osteogenic conditions prior to implantation. Results were compared with non-loaded scaffolds (group C). Animals were killed for investigation at 4 and at 8 weeks. RESULTS: In situ hybridization demonstrated integration of MSC for up to 8 weeks in groups A and B. Histology revealed significantly more extracellular matrix synthesis in MSC-seeded scaffolds containing calcium phosphate and collagen type I at 4 and 8 weeks after transplantation compared with unloaded controls. At a biochemical level, higher levels of specific alkaline phosphatase expression were detected in MSC-loaded scaffolds (P<0.05). Scaffolds containing undifferentiated and differentiated MSC did not appear to differ in terms of matrix synthesis and protein expression, while the number of avital cells was significant higher in those probes loaded with differentiated MSC (P<0.01). DISCUSSION: The integration of transplanted cells and MSC-associated matrix synthesis encourages the use of MSC-loaded mineralized collagen for tissue engineering of bone. Furthermore, our data suggest that in vitro differentiation of MSC does not have a positive influence in terms of improved matrix synthesis.

Adult↗
PubMed2006

Mesenchymal stem cells maintain TGF-beta-mediated chondrogenic phenotype in alginate bead culture.

This article addresses the stability of chondrogenic phenotype and the transdifferentiation potential of bone marrow-derived mesenchymal stem cells (MSCs) at distinct stages of differentiation. Differentiated MSCs were expected to maintain cartilage-like gene expression pattern in the absence of any chondrogenic growth factor or in the presence of osteogenic signals. MSCs encapsulated in alginate beads were treated with transforming growth factor (TGF)-beta 3 for 3, 6, or 14 days and then cultured in absence of TGF-beta for the remainder of the 2-week culture period. Additionally, cells were cultured in osteogenic medium after TGF-beta-mediated chondroinduction. Gene expression of col2a1, aggrecan, COMP, alkaline phosphatase (AP), and correlating protein synthesis was analyzed. After short-term stimulation with TGF-beta, MSCs maintained a chondrogenic phenotype. Chondrogenic gene expression and protein synthesis directly correlated with the extent of stimulation time and the concentration of TGF-beta. Pretreatment with TGF-beta could prevent AP mRNA expression of encapsulated MSCs. TGF- beta stimulation within the first 3 days of culture seems to be crucial for the expression of a chondrogenic phenotype. Fully differentiated and encapsulated MSCs are not able to transdifferentiate into osteoblasts. These findings give rise to a better understanding of the behavior of cartilage grafts affected by local factors of osteochondral transplantation sites in vivo.

Adult↗
PubMed2006

Clinical and radiological findings after different treatment of odontoid fractures type Anderson II and III.

PURPOSE OF THE STUDY: In the period from 06/00 to 08/02, 31 patients with odontoid fractures type Anderson II and III were treated and stastically recorded. 25 patients were followed up; the progess of 24, documented in detail radiographically, were evaluated independently by a traumatologist and by a radiologist. The usual time of immobilization when treating odontoid fractures type Anderson type II and III with the halo-fixator is 12 weeks. For this 12 weeks that it is worn, objective assessment of bone healing is performed radiographically and the results critically considered in terms of the length of time that the halo-fixator should be worn and whether this duration should be altered on the basis of the clinical and radiological results obtained. MATERIALS AND METHODS: 16 patients with an odontoid fracture type Anderson type II were treated partly with a halo-fixator and partly by additional operative stabilization. 15 patients with a type III fracture were treated in a halo over 12 weeks. At the time of the accident the patients to be treated had to have conventional radiographic examination and a CT scan as well as a position check following reduction. After 4, 8 and 12 weeks radiographic and CT investigation was repeated. These findings were evaluated independently by a surgeon and a radiologist. The clinical follow-up was carried out using the VAS Score and, in addition, the general activity level before and after the accident was recorded in a similar way on the Tegner/Lysholm subjective activity score. RESULTS: In most cases, according to the CT scan, the osseous bridging decreased again between the 8th and 12th weeks, as defined by resorption zones seen during the fracture healing period. Radiological evidence of complete osseous bridging was only seen after 12 weeks in three cases. CONCLUSION: Conventional radiography does not seem to us to be the most suitable technical means to evaluate osseous healing in odontoid fractures. The CT is more reliable for this. According to our radiological results, osseous healing of different types of odontoid fractures takes more than 12 weeks. Despite of its known complications, the halo fixator is still a good instrument for the treatment of odontoid fractures.

Adult↗
PubMed2006

Principles and clinical application of the locking compression plate (LCP).

The principle of the locking compression plate (LCP) is represented by the combination of two completely different anchorage technologies and two opposed principles of osteosynthesis in one implant it combines the principles of conventional plate osteosynthesis for direct anatomical reduction with those of bridging plate osteosynthesis. Since the LCP can be used as a conventional plate using only dynamic compression, as a pure internal fixator using locking head screws, or as both combined, it provides the surgeon with multiple variations. Nevertheless, these new possibilities mean that preoperative planning and an understanding of the different biomechanical principles of osteosynthesis are essential if good clinical outcomes are to be achieved and maximum benefit is to be attained from the options offered by the LCP system. The current article provides biomechanical background to and guidelines for the use of LC plates in the operative treatment of fractures and also reports experimental and clinical results obtained with LCP.

Biomechanical Phenomena↗
PubMed2006

[Complex injuries of the shoulder - floating shoulder].

Complex injuries of the shoulder are comparatively rare. Within the field of complex shoulder injuries this article particularly deals with the diagnosis and therapy of the "floating shoulder injury" as a review article. This term describes a discontinuation of the osseus and soft tissue suspension of the upper extremity from the axial skeleton. By literature review and involvement of recent biomechanical studies this article will show the injury patterns that lead to instability of the shoulder girdle and the therapeutic to be employed in respective cases. Key words: shoulder, floating shoulder, clavicle fracture, scapula fracture.

Acromioclavicular Joint↗
PubMed2005

[Polytrauma in cyclists. Incidence, etiology, and injury patterns].

BACKGROUND: In our region we have noticed an increasing number of cyclists and consequently a rise in bicycle-related accidents in recent years. A large number of our polytraumatized patients are victims of bicycle-related accidents. MATERIAL AND METHODS: Retrospectively we analyzed the data of our polytraumatized patients recorded between May 2003 and June 2004 for bicycle-related injuries. Of 153 polytraumatized patients treated in our emergency room 32 were cyclists (21%). The average age of our polytraumatized cyclist was 42 years, and the male-to-female ratio was 1:1. RESULTS: The median score on the Glasgow Coma Scale (GCS) after the accident was 8 (min. 3, max. 15), the median Injury Severity Score (ISS) was 24 (min. 18, max. 41), and the median Polytrauma Score (PTS) was 23 (min. 14, max. 51). A total of 30 patients (94%) suffered a head injury; in 28 patients (88%) the head injury was the leading diagnosis. The median score on the Abbreviated Injury Scale (AIS) Head was 4 (min. 1, max. 5), the AIS Thorax 3 (min. 2, max. 4), and the AIS Extremities 3 (min, 2, max. 5). Our data were also compared with the official injury statistics of the region and the current literature. CONCLUSION: The most frequent and most severe injury was the head injury (94%). Of the 32 polytraumatized cyclists 30 did not wear a helmet. Successful prevention could possibly be practiced if all cyclists wear helmets.

Abdominal Injuries↗
PubMed2005

Stimulation of chondrocytes in vitro by gene transfer with plasmids coding for epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF).

Human epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF) influence critical characteristics of chondrocytes. The effects on metabolism and differentiation were evaluated following transfection using specific plasmids coding for both cytokines. Chondrocytes were isolated from femoral head cartilage of patients undergoing a hip arthroplasty for femoral neck fracture. Following collagenase-digestion, cells were cultured in monolayers, and cell proliferation, glucosaminoglycan-production and collagen type II expression were monitored 10 days after isolation. Addition of recombinant hEGF and bFGF resulted in a significant increase in cell proliferation and glucosaminoglycan production. Chondrocytes were transfected with vectors coding for either hEGF or bFGF and the production of these proteins was measured in supernatants by ELISA. Expression kinetics showed different patterns: hEGF was detectable 2.5 days following transfection and peaked at day 5.5, whereas bFGF-production reached its maximum 1.5 days after transfection, declining thereafter. Chondrocytes endogenously produced significant amounts of bFGF within 5 days following isolation. Proliferation of hEGF-transfected cells increased up to 81%; bFGF-transfection caused an increase up to 76%. Similarly, glucosaminoglycan-production was enhanced up to 120% by hEGF-transfection and 37% by bFGF transfection, respectively. Collagen type II production decreased following transfection with both plasmids. Temporary in vitro gene transfer of the growth factors hEGF and bFGF provides a method to stimulate chondrocyte proliferation and induces signs of dedifferentiation, which would limit a reasonable clinical application.

Aged↗
PubMed2005

[Rupture of the pectoralis major muscle -- causes, diagnosis, treatment].

PURPOSE OF THE STUDY: Between 01/02 and 01/03 four cases of ruptures of the pectoralis major muscle were treated in our hospital by suture. The data were retrospectively analysed, all patients underwent a follow up examination. We compared our results with the literature found by internet search. PATIENTS AND METHODS: Between 01/02 and 01/03 four male patients with a rupture of the pectoralis major muscle (PM) were treated surgically by suture. Three of them had an acute rupture (75%), in one case the injury was older (25%). In three cases patients underwent MRI examination. All patients were examined for a follow up by the Constant score and the score of McEntire. RESULTS: The median age of the patients was 36.5 (min: 27; max: 51) years; in three cases the left side was injured, in one case the right. All cases of the acute injury happened during weight bearing. The older rupture (1.5 years ago) was caused by a motorcycle accident. The follow up examination was performed after 8.5 (min: 7; max: 13) months. According to the score of McEntire the functional and clinical result was in all cases good to very good. The median value of the Constant score on the injured side was 90 (min: 63; max: 96) compared to 99 (min: 95; max: 100) on the other side. CONCLUSION: The rupture of the pectoralis major muscle is a rare entity and appears in young male patients. The most common reason for this injury is weight bearing or physical exercises, often in combination with anabolic steroids. Clinical and functional results after suture are good; patients normally reach the former level of activity and are able to practice their sports in the same way like they did before the trauma. According to our experiences, we recommend the surgical therapy.

Adult↗