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Biomedical subjects

N Popova

Publications and source records attributed to N Popova.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Participation of cyclic-3',5'-adenosine monophosphate in the pathogenesis of myocardial hypertrophy in experimental hypertension].

The authors examined the concentration of cAMP in the myocardium of rats with experimental hypertension during various periods after modeling of the process. The changes in the values of cyclic nucleotide corresponded to the dynamics of the development of the arterial hypertension. There was na increase of the level of cAMP in the myocardium on the third day after modeling of hypertension, accompanying the initial elevation of the arterial pressure. The maximal values of cAMP were established on the 30th day, which corresponded to the maximal development of hypertension. Cyclic 3,5-adenomonophosphate began to diminish parallel to the lowering of the arterial pressure during the chronic phase 90th day. The obtained results give a possibility to discuss the participation of cAMP in the pathogenesis of myocardial hypertension, occurring in experimental hypertension.

Animals↗
PubMed1977

[Experimental hypertension in rats and their adrenal activity].

The authors examined dynamically the arterial pressure and plasma activity of 11-hydroxycorticosteroids in two groups of rats with pure hypertension and with hypertension on the background of beta-adrenergic activity. There was an elevation of arterial pressure in both groups, less manifested in the rats, treated with beta blocker. The values after six months were equally high in both groups. The content of 11-hydroxycorticosteroids was increased with a maximum at the sixth month. The authors make an inference that beta blocker-obsidan lowers blood pressure, but does not affect the level of 11-hydroxycorticosteroidids in plasma.

11-Hydroxycorticosteroids↗
PubMed1977

[Effect of beta-adrenergic blockade on acid-base balance in experimental hypertension].

On rats with experimental hypertension by method of Selye, modified by Kolarova, distributed in two groups--treated by obsidan and untreated, the following parameters on the 1st and the 3rd month after the operation were studied: pH, BB, SB, AB, BE, PaCO2, TCO2, PaO2, and SaO2. In the hypertonic animals we establish a decompensated metabolic acidosis on the 1st month and a metabolic acidosis with a marked respiratory compensation on the 3rd month. The hypertonic animals, treated by obsidan, demonstrate a sharp tendency to normalise the parameters of the acid-base status on the 1st month and normal values on the 3rd. The protective obsidan effect observed on the hypertonic rat we discuss as a result of metabolic and functional influences of the beta-adrenergic blockers.

Acidosis↗
PubMed1976

[Changes in myocardial activity of several enzymes of glycolysis, the tricarboxylic acid cycle and pentosephosphate shunt in rats with experimental hypertension].

The authors examined dynamicaly from the third day to the third month the activity of enzymes, participating in glycolysis (ALD, PK, LDH), pentosemonophosphate shunt (G6P-DH), citric cycle (MDH, INDH) in the myocardium of rats with hypertension, induced by the method of Selye, modified by Kolarova. There were phase changes in enzymatic activity in the myocardium, manifested at the first stages by lowering (LDH, ALD, INDH) or elevation (MDH, PK, G6-DH). The activity of all examined enzymes was over that of the control group on the thirteenth day, while there were also oscillations on the nineteenth day. Only the actimity of G6-DH revealed a progressive elevation during the whole experimental period. The changes in the enzymic activity of the myocardium at the first stages were interpreted as a sign of nonspecific adaptation to the changed conditions of heart activity. The later changes were manifestations of the disturbances at various metabolic links, which were unevenly involved in the processes of myocardial hypertrophy.

Aldehyde-Lyases↗
PubMed1976

[Changes in renal enzyme activity in rats with experimental hypertension].

The study was carried out on rats of the Wistar strain with experiments hypertension by the method of Selye, modified by Kolarova. These authors examined the activity of the enzymes of protein metabolism (GOT, GPT, AP), of glycolysis (ALD, LDH, alpha-HBDH) and of the citric cycle (MDH) in the left and right kidney at various intervals after modeling the process (3th, 15th, 30th and 90th day). The activity of the enzymes of the glycolytic chain and the cycle of Krebs in the left kidney was lowered at all stages of the experiment. Transaminase activity diminished progressively. Such a dynamics revealed the activity of adenosine phosphate as well. The activity of all examined enzymes of the right kidney showed phase changes-after initial elevation on the third day there was a lowering at the later stages of the experiment. The altered activity off the left kidney was connected with the disturbed vascularization with subsequent metabolic changes. The changes in the enzymic activity in the right kidney were assumed as a consequence of the occurred adaptive hyperfunction.

Alanine Transaminase↗