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Biomedical subjects

N Positano

Publications and source records attributed to N Positano.

At least 19 recordsLinked to original sources
PubMed1991

Monotherapy with nilutamide, a pure nonsteroidal antiandrogen, in untreated patients with metastatic carcinoma of the prostate. The Italian Prostatic Cancer Project.

A total of 26 previously untreated patients with metastatic carcinoma of the prostate received the pure nonsteroidal antiandrogen nilutamide as a single agent. Objective response rate was 38.5 +/- 18.7% (95% confidence interval). Median progression-free survival and median survival were 9 and 23 months, respectively. Of 13 patients with progression on antiandrogen 5 showed an additional objective response to a second-line endocrine treatment. The drug was generally well tolerated, except for 2 patients who discontinued treatment because of moderate gastrointestinal symptoms. Approximately a third of the patients complained of decreased adaptation to darkness. An electroretinogram and dark adaptation test revealed the presence of functional damage and visual complaints reversed in all patients on cessation of therapy. The other most frequent side effects were slight nausea (26.9% of the patients) and alcohol intolerance (19.2%). A nonsignificant increase in testosterone levels was shown within 1 month of treatment, after which the levels remained stable. Approximately half of the sexually active men claimed maintenance of libido and sexual potency during treatment. A slightly significant increase in hemoglobin was observed during the long term, suggesting the occurrence of a trophic effect by androgens on erythropoiesis. The results indicate that nilutamide as a single agent has an acceptable toxicity and a moderate activity, and may maintain sexual interest in a discrete number of cases. Whether monotherapy with nonsteroidal antiandrogens offers a valid option in the palliation of advanced disease remains to be seen in comparative prospective trials.

Androgen Antagonists↗
PubMed1983

[Histological follow-up after implantation of grains of I-125 for prostatic cancer].

The authors report a preliminary study of 12 cases of carcinoma of the prostate confined to the prostate (T1, T2, T3, NO, MO) treated by pelvic lymphadenectomy and the implantation of grains of I 125 in the prostatic tissue. Irradiation continued for six months, providing most dose of 100 Gy in the prostate. Interstitial irradiation caused not only the destruction of tumour cells but also "radiation prostate" lesions with vascular obliteration which itself caused sufficient impairment of the vitality of the prostatic tissue for any residual tumour to disappear with a frequency which increased with the time elapsing between the follow up prostatic biopsy and the implantation of radioactive iodine. Experience remains limited but the initial figures given here suggest the validity of continuing along these lines.

Adenocarcinoma↗
PubMed1981

[Percutaneous embolization of renal cancer. Clinical evaluation (author's transl)].

The authors deal with 17 cases of renal adenocarcinoma treated with preventive embolization, widened nephrectomy and total parenteral nutrition, as well as one case of palliative definitive embolization in a patient who could not be operated. The most remarkable clinical aspects turned out to be in the easier and safer maneuverability under surgery, a decrease in mortality during and after the operation, reduced consumption of blood units, and a better which were treated only with purely surgical therapy.

Adenocarcinoma↗
PubMed1980

Hematuria due to circumaortic left renal vein.

A patient with benign recurrent hematuria underwent selective renal venography, manometric registration of pressure levels in the renal veins, and renal biopsy which indicated the circumaortic left renal veins was responsible for intermittent hematuria and proteinuria.

Adult↗
PubMed1980

[Therapeutic angiographic occlusion with a modified autologous clot. Case report].

Therapeutic arterial embolization with autologous clot is readily applied in urology. The procedure is particularly effective in those cases where a temporary blockage of the artery is required, enough to cause a definitive haemostasis in noble parenchymas sensitive to ischaemia. However this method is not limited only to poor risk patients ("life-threatening"); it may be preferable to surgical operation, as in the case studied, of postraumatic, intraparenchymal arterovenous fistula. In their presentation, the authors also take into consideration several technical side-effects, helping towards correct execution.

Abdominal Injuries↗
PubMed1980

[Transluminal angioplasty of the renal artery for renovascular hypertension (author's transl)].

The authors report an interesting case of dilatation of renal artery stenosis by inflation of the balloon of a catheter engaged in the stenosed arterial lumen inserted percutaneously under arteriographic control. The patient's hypertension responded within a few hours and plasma renin levels in the systemic circulation became normal within a few days. This result was stable at 2 months. In the opinion of the authors, this technique of percutaneous transluminal angioplasty, initially used for arterial obstructions of the lower limbs, carotid and coronary obstructions, should find a wide field of application in the area of renovascular hypertension.

Catheterization↗
PubMed1980

[The subclavian approach as an alternative to the femoral approach in selective cervicocephalic phlebography (author's transl)].

The authors describe the technique employed for selective catheterization of the main mediastinal trunks and the veins of the brachiocephalic and cervicocephalic regions by means of the subclavian approach. The importance and advantages of this procedure as an alternative to the femoral approach, especially if this is contra-indicated, are emphasized.

Catheterization↗
PubMed1979

Multiple sampling for parathyroid hormone by subclavian approach.

Selective venous catheterization with parathyroid hormone assay is a valuable procedure in the diagnosis and treatment of parathyroid tumors. The multiple sampling via the femoral vein is sometimes frustratingly uncertain and time consuming. The technique herein described is simpler, quicker, and less hazardous. It is accomplished via the subclavian approach, a relatively easier anatomic way, and utilizes a short single-curve catheter that gives a high degree of torsion control.

Adenoma↗
PubMedDate not supplied

[Revascularization of bladder neoplasms after percutaneous embolization of the hypogastric arteries].

The authors report a case of revascularization through the inferior mesenteric artery of a bladder tumor, which had previously been treated by embolization of both hypogastric arteries because of hemorrhage. Percutaneous embolization of the hypogastric arteries with various types of material has stimulated considerable interest among urologists, when used to treat hematuria which cannot be checked in patients with inoperable vesical neoplasms. As described by various authors, a tissue adhesive, N-butyl-2-cyanoacrylate (Blue histoacryl = Braun), which produces definite and irreversible circulatory arrest in the circulation in the neoplastic mass, was studied. The use of this material, introduced into clinical practice in Italy, especially by Giulian's school after many animal experimental studies, appeared to the authors to be elective in certain cases studied. The first patients in which it was used produced very convincing results as the hemorrhagic symptoms stopped immediately, without any obvious secondary reactions being observed. In one case, however, the immediate good result was followed by a return of the hemorrhage 6 months later.

Aged↗