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N Profizi

Publications and source records attributed to N Profizi.

22 records · Page 2Linked to original sources
PubMedDate not supplied

Serum HIV-1 RNA load to predict CD4+ T-cell depletion in asymptomatic patients.

The temporal association between the increase in viral replication and the depletion in CD4+ T cells in HIV-1 infection is not yet clear. To investigate this phenomenon HIV-1 RNA was quantified in several frozen sera from 20 asymptomatic HIV-1 infected patients in the 2 years preceding CD4+ T cell depletion of 50% or more, and compared with 20 HIV-1 infected paired patients who were stable in the same period. In each group, no statistically significant variation in the mean HIV-1 RNA titre was found between the last checkup and the one 24 months earlier. The mean HIV-1 RNA titre was 10(3.86) copies/ml in the non-progressor group and 10(5.12) copies/ml in the progressor group. These data support the view that the quantity of circulating HIV-1 RNA is an early predictor of disease progression that is relatively constant during the asymptomatic period of HIV-1 infection.

Adult↗
PubMedDate not supplied

Correlation between plasma levels of cytokines and HIV-1 RNA copy number in HIV-infected patients.

The plasma levels of HIV-1 RNA, tumor necrosis factor alpha (TNF-alpha), soluble receptors type II of TNF-alpha (sTNF-alpha RII), soluble receptors of interleukin-4 (sR IL-4), interleukin-6 (IL-6), soluble receptors of interleukin-6 (sR IL-6), granulocyte macrophage colony stimulating factor (GM-CSF), soluble receptors of GM-CSF (sR GM-CSF), RANTES, MIP-1 alpha and MIP-1 beta were measured in 80 HIV-infected patients. All patients had not been treated previously with antiretroviral drugs and did not present a recent history of opportunistic infection. A statistically significant correlation was found between HIV-1 RNA and TNF-alpha (p = 0.005) or sTNF-alpha RII levels (p < 0.001). RANTES and MIP-1 alpha levels did not correlate with HIV-1 RNA. MIP-1 beta levels were correlated with plasma RNA titers in patients with CD4+ T cells < 200 x 10(6)/l (p = 0.03). MIP-1 alpha and sR IL-4 levels were significantly different according to the CD4+ T cell range (p = 0.003 and p = 0.0002, respectively). GM-CSF and sR GM-CSF were undetectable in each case. These data confirm that HIV-1 replication in the plasma is correlated with TNF-alpha levels, but do not show a clear correlation with levels of the chemokines studied.

Acquired Immunodeficiency Syndrome↗