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N Qian

Publications and source records attributed to N Qian.

At least 19 recordsLinked to original sources
PubMed2001

Practising orientation identification improves orientation coding in V1 neurons.

The adult brain shows remarkable plasticity, as demonstrated by the improvement in fine sensorial discriminations after intensive practice. The behavioural aspects of such perceptual learning are well documented, especially in the visual system. Specificity for stimulus attributes clearly implicates an early cortical site, where receptive fields retain fine selectivity for these attributes; however, the neuronal correlates of a simple visual discrimination task remained unidentified. Here we report electrophysiological correlates in the primary visual cortex (V1) of monkeys for learning orientation identification. We link the behavioural improvement in this type of learning to an improved neuronal performance of trained compared to naive neurons. Improved long-term neuronal performance resulted from changes in the characteristics of orientation tuning of individual neurons. More particularly, the slope of the orientation tuning curve that was measured at the trained orientation increased only for the subgroup of trained neurons most likely to code the orientation identified by the monkey. No modifications of the tuning curve were observed for orientations for which the monkey had not been trained. Thus training induces a specific and efficient increase in neuronal sensitivity in V1.

Animals↗
PubMed2001

Transcranial magnetic stimulation differentially affects speed and direction judgments.

This study was conducted to determine whether humans' judgments about the speed and direction of moving stimuli was differentially affected by transcranial magnetic stimulation (TMS). Subjects viewed two successively presented moving stimuli that differed from each other both in speed and direction of motion. Single-pulse TMS was applied either medially (approximately 2 cm above the inion) or laterally (approximately 5 cm lateral to and 4 cm above the inion), while subjects judged the speed and direction differences. The physical stimulation (visual and TMS) was identical on the two tasks, as was discriminability (d') when TMS was not applied. We found significant criterion (beta) shifts on the speed discrimination task at both stimulation sites. Specifically, on TMS trials the proportion of "slower" judgments increased significantly, consistent with subjective reports that stimuli often appeared to slow when TMS was applied. The subjective reports indicated no corresponding change in perceived direction. We also found that speed discriminability was impaired significantly more than direction discriminability, but only when TMS was applied medially. Indeed, after controlling for TMS-related changes in reaction time, speed discriminability was impaired significantly, while direction discriminability remained largely intact. This dissociation suggests that the sensory response constraining speed discrimination is at least partially independent from the sensory response constraining direction discrimination. Combined with previous psychophysical data, the present data suggest a double dissociation between speed and direction discrimination in humans.

Adult↗
PubMed2001

The effect of orientation learning on contrast sensitivity.

Regan and Beverley [Regan, D., & Beverley, K. I. (1985). Postadaptation orientation discrimination. Journal of the Optical Society of America A, 2(2), 147-155] previously demonstrated that adapting to an oriented visual stimulus improves sensitivity to subtle orientation differences while impairing contrast sensitivity. Here, we investigated whether practice-based improvements in orientation sensitivity would, like adaptation, impair contrast sensitivity. To the contrary, we found that contrast sensitivity actually improved significantly after observers demonstrated practice-based increases in orientation sensitivity. Therefore, while orientation sensitivity can be enhanced either by orientation-discrimination training or by adapting to visual stimuli, these two procedures have opposite effects on contrast sensitivity. This difference suggests that adaptation and perceptual learning on orientation discrimination cannot be explained sufficiently by a shared underlying cause, such as a reduction in neural activity.

Adaptation, Physiological↗
PubMed2001

Motion rivalry impairs motion repulsion.

In their classic study on motion repulsion, Marshak and Sekuler (Science 205 (1979) 1399) reported a repulsion of up to 10 degrees when two different directions of motion were presented dichoptically. However, subjects in that study did not experience binocular rivalry, presumably because of the brief presentation time. In the present study, we measured repulsion during binocular rivalry by requiring subjects to dichoptically view the stimuli until one direction of motion appeared to exclusively dominate the other (Blake, Yu, Lokey, & Norman (1998). J. Cogn. Neurosci., 10, 46-60). We found that motion repulsion was significantly reduced during exclusive dominance. Indeed, after controlling for reference repulsion--the misjudgment of a single direction of motion (Rauber & Treue (1998). Perception, 27, 393-402)--we found no significant motion repulsion during exclusive dominance. These data suggest that motion repulsion may require the perception, rather than merely the physical presence, of multiple directions.

Humans↗
PubMed2001

Modeling V1 disparity tuning to time-varying stimuli.

Most models of disparity selectivity consider only the spatial properties of binocular cells. However, the temporal response is an integral component of real neurons' activities, and time-varying stimuli are often used in the experiments of disparity tuning. To understand the temporal dimension of V1 disparity representation, we incorporate a specific temporal response function into the disparity energy model and demonstrate that the binocular interaction of complex cells is separable into a Gabor disparity function and a positive time function. We then investigate how the model simple and complex cells respond to widely used time-varying stimuli, including motion-in-depth patterns, drifting gratings, moving bars, moving random-dot stereograms, and dynamic random-dot stereograms. It is found that both model simple and complex cells show more reliable disparity tuning to time-varying stimuli than to static stimuli, but similarities in the disparity tuning between simple and complex cells depend on the stimulus. Specifically, the disparity tuning curves of the two cell types are similar to each other for either drifting sinusoidal gratings or moving bars. In contrast, when the stimuli are dynamic random-dot stereograms, the disparity tuning of simple cells is highly variable, whereas the tuning of complex cells remains reliable. Moreover, cells with similar motion preferences in the two eyes cannot be truly tuned to motion in depth regardless of the stimulus types. These simulation results are consistent with a large body of extant physiological data, and provide some specific, testable predictions.

Animals↗
PubMed2000

The dependence of motion repulsion and rivalry on the distance between moving elements.

We investigated the extent to which motion repulsion and binocular motion rivalry depend on the distance between moving elements. The stimuli consisted of two sets of spatially intermingled, finite-life random dots that moved across each other. The distance between the dots moving in different directions was manipulated by spatially pairing the dot trajectories with various precisions. Data from experiment 1 indicated that motion repulsion occurred reliably only when the average distance between orthogonally moving elements was at least 21.0 arc min. When the dots were precisely paired, a single global direction intermediate to the two actual directions was perceived. This result suggests that, at a relatively small spatial scale, interaction between different directions favors motion attraction or coherence, while interaction at a somewhat larger scale generates motion repulsion. Similarly, data from experiment 2 indicated that binocular motion rivalry was significantly diminished by spatially pairing the dots, which moved in opposite directions in the two eyes. This supports the recent proposal that rivalry occurs at or after the stage of binocular convergence, since monocular cells could not have directly responded to our interocular pairing manipulation. Together, these findings suggest that the neural mechanisms underlying motion perception are highly sensitive to the fine spatial relationship between moving elements.

Convergence, Ocular↗
PubMed2000

A physiologically-based explanation of disparity attraction and repulsion.

Westheimer and Levi [(1987) Vision Research, 27, 1361-1368] found that when a few isolated features are viewed foveally, the perceived depth of a feature depends not only on its own disparity but also on those of its neighbors. The nature of this interaction is a function of the lateral separation between the features: When the distance is small the features appear to attract each other in depth but the interaction becomes repulsive at larger distances. Here we introduce a two-dimensional extension of our recent stereo model based on the physiological studies of Ohzawa, DeAngelis and Freeman [(1990) Science, 249, 1037-1041] and demonstrate through analyses and simulations that these observations can be naturally explained without introducing ad hoc assumptions about the connectivity between disparity-tuned units. In particular, our model can explain the distance-dependent attraction/repulsion phenomena in both the vertical-line configuration used by Westheimer [(1986) Journal for Neurophysiology, 370, 619-629], and the horizontal-line-and-point configuration used by Westheimer and Levi. Thus, the psychophysically observed disparity interaction may be viewed as a direct consequence of the known physiological organization of the binocular receptive fields. We also find that the transition distance at which the disparity interaction between features changes from attraction to repulsion is largely determined by the preferred spatial frequency and orientation distributions of the cells used in the disparity computation. This result may explain the observed variations of the transition distance among different subjects in the psychophysical experiments. Finally, our model can also reproduce the observed effect on the perceived disparity when the disparity magnitude of the neighboring features is changed.

Computer Simulation↗
PubMed2000

Relationship between phase and energy methods for disparity computation.

The phase and energy methods for computing binocular disparity maps from stereograms are motivated differently, have different physiological relevances, and involve different computational steps. Nevertheless, we demonstrate that at the final stages where disparity values are made explicit, the simplest versions of the two methods are exactly equivalent. The equivalence also holds when the quadrature-pair construction in the energy method is replaced with a more physiologically plausible phase-averaging step. The equivalence fails, however, when the phase-difference receptive field model is replaced by the position-shift model. Additionally, intermediate results from the two methods are always quite distinct. In particular, the energy method generates a distributed disparity representation similar to that found in the visual cortex, while the phase method does not. Finally, more elaborate versions of the two methods are in general not equivalent. We also briefly compare these two methods with some other stereo models in the literature.

Animals↗
PubMed1999

Axis-of-motion affects direction discrimination, not speed discrimination.

The motion of an object can be described by a single velocity vector, or equivalently, by direction and speed separately. Similarly, our ability to see subtle differences in the motion of two objects could be constrained by either a velocity-based sensory response, or separate sensory responses to direction and speed. To distinguish between these possibilities we investigated whether direction discrimination and speed discrimination were differentially affected by changes in the axis-of-motion. Psychophysical data from 12 naive observers indicated that direction discrimination depended on axis-of-motion, but speed discrimination did not. The difference suggests that a velocity-based sensory response is not the limiting factor on the two tasks. Instead, the results imply that the sensory response which constrains speed discrimination is at least partially independent from the sensory response which constrains direction discrimination.

Differential Threshold↗
PubMed1999

Perceptual learning on orientation and direction discrimination.

Two experiments were conducted to determine the extent to which perceptual learning transfers between orientation and direction discrimination. Naive observers were trained to discriminate orientation differences between two single-line stimuli, and direction differences between two single-moving-dot stimuli. In the first experiment, observers practiced the orientation and direction tasks along orthogonal axes in the fronto-parallel plane. In the second experiment, a different group of observers practiced both tasks along a single axis. Perceptual learning was observed on both tasks in both experiments. Under the same-axis condition, the observers' orientation sensitivity was found to be significantly elevated after the direction training, indicating a transfer of learning from direction to orientation. There was no evidence of transfer in any other cases tested. In addition, the rate of learning on the orientation task was much higher than the rate on the direction task. The implications of these findings on the neural mechanisms subserving orientation and direction discrimination are discussed.

Discrimination, Psychological↗
PubMed1998

The effect of complex motion pattern on speed perception.

We recently reported a new motion illusion where dots in expanding random dot patterns appear to move faster than those in rotation patterns despite having the same physical speed distributions. In the current paper, we compared expansion and rotation motion to translational motion and found that the perceived dot speed in translation patterns was between that of expansion and rotation. We also explored contraction motion and found subjects perceived dots in contracting patterns as moving slightly faster than those in expanding patterns and much faster than those in rotating patterns. Finally, we found that stimulus presentation order in a trial plays an important role in determining the magnitude of the speed illusion--the effect is greater when the subjectively faster stimulus is viewed second (e.g., expansion after rotation). The dependence on stimulus order is greatest when comparing complex motion patterns with large subjective speed differences. This phenomenon is unlikely to be explained in terms of channel fatigue or adaptation.

Humans↗
PubMed1998

IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.

Human chromosome 11p15.5 and distal mouse chromosome 7 include a megabase-scale chromosomal domain with multiple genes subject to parental imprinting. Here we describe mouse and human versions of a novel imprinted gene, IMPT1 , which lies between IPL and p57 KIP2 and which encodes a predicted multi-membrane-spanning protein similar to bacterial and eukaryotic polyspecific metabolite transporter and multi-drug resistance pumps. Mouse Impt1 and human IMPT1 mRNAs are highly expressed in tissues with metabolite transport functions, including liver, kidney, intestine, extra-embryonic membranes and placenta, and there is strongly preferential expression of the maternal allele in various mouse tissues at fetal stages. In post-natal tissues there is persistent expression, but the allelic bias attenuates. An allelic expression bias is also observed in human fetal and post-natal tissues, but there is significant interindividual variation and rare somatic allele switching. The fact that Impt1 is relatively repressed on the paternal allele, together with data from other imprinted genes, allows a statistical conclusion that the primary effect of human chromosome 11p15.5/mouse distal chromosome 7 imprinting is domain-wide relative repression of genes on the paternal homolog. Dosage regulation of the metabolite transporter gene(s) by imprinting might regulate placental and fetal growth.

Adult↗
PubMed1997

A physiological model for motion-stereo integration and a unified explanation of Pulfrich-like phenomena.

Many psychophysical and physiological experiments indicate that visual motion analysis and stereoscopic depth perception are processed together in the brain. However, little computational effort has been devoted to combining these two visual modalities into a common framework based on physiological mechanisms. We present such an integrated model in this paper. We have previously developed a physiologically realistic model for binocular disparity computation (Qian, 1994). Here we demonstrate that under some general and physiological assumptions, our stereo vision model can be combined naturally with motion energy models to achieve motion-stereo integration. The integrated model may be used to explain a wide range of experimental observations regarding motion-stereo interaction. As an example, we show that the model can provide a unified account of the classical Pulfrich effect (Morgan & Thompson, 1975) and the generalized Pulfrich phenomena to dynamic noise patterns (Tyler, 1974; Falk, 1980) and stroboscopic stimuli (Burr & Ross, 1979).

Depth Perception↗
PubMed1997

Physiological computation of binocular disparity.

We previously proposed a physiologically realistic model for stereo vision based on the quantitative binocular receptive field profiles mapped by Freeman and coworkers. Here we present several new results about the model that shed light on the physiological processes involved in disparity computation. First, we show that our model can be extended to a much more general class of receptive field profiles than the commonly used Gabor functions. Second, we demonstrate that there is, however, an advantage of using the Gabor filters: similar to our perception, the stereo algorithm with the Gabor filters has a small bias towards zero disparity. Third, we prove that the complex cells as described by Freeman et al. compute disparity by effectively summing up two related cross products between the band-pass filtered left and right retinal image patches. This operation is related to cross-correlation but it overcomes some major problems with the standard correlator. Fourth, we demonstrate that as few as two complex cells at each spatial location are sufficient for a reasonable estimation of binocular disparity. Fifth, we find that our model can be significantly improved by considering the fact that complex cell receptive field are, on average, larger than those of simple cells. This fact is incorporated into the model by averaging over several quadrature pairs of simple cells with nearby and overlapping receptive fields to construct a model complex cell. The disparity tuning curve of the resulting complex cell is much more reliable than the constructed from a single quadrature pair of simple cells used previously, and the computed disparity maps for random dot stereograms with the new algorithm are very similar to human perception, with sharp transitions at disparity boundaries. Finally, we show that under most circumstances our algorithm works equally well with either of the two well-known receptive field models in the literature.

Algorithms↗
PubMed1997

The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis.

We searched for novel imprinted genes in a region of human chromosome 11p15.5, which contains several known imprinted genes. Here we describe the cloning and characterization of the IPL ( I mprinted in P lacenta and L iver) gene, which shows tissue-specific expression and functional imprinting, with the maternal allele active and the paternal allele relatively inactive, in many human and mouse tissues. Human IPL is highly expressed in placenta and shows low but detectable expression in fetal and adult liver and lung. Mouse Ipl maps to the region of chromosome 7 which is syntenic with human 11p15.5 and this gene is expressed in placenta and at higher levels in extraembryonic membranes (yolk sac), fetal liver and adult kidney. Mouse and human IPL show sequence similarity to TDAG51 , a gene which was shown to be essential for Fas expression and susceptibility to apoptosis in a T lymphocyte cell line. Like several other imprinted genes, mouse and human IPL genes are small and contain small introns. These data expand the repertoire of known imprinted genes and will be helpful in testing the mechanism of genomic imprinting and the role of imprinted genes in growth regulation.

Amino Acid Sequence↗
PubMed1996

Binocular receptive field models, disparity tuning, and characteristic disparity.

Disparity tuning of visual cells in the brain depends on the structure of their binocular receptive fields (RFs). Freeman and coworkers have found that binocular RFs of a typical simple cell can be quantitatively described by two Gabor functions with the same gaussian envelope but different phase parameters in the sinusoidal modulations (Freeman and Ohzawa 1990). This phase-parameter-based RF description has recently been questioned by Wagner and Frost (1993) based on their identification of a so-called characteristic disparity (CD) in some cells' disparity tuning curves. They concluded that their data favor the traditional binocular RF model, which assumes on overall positional shift between a cell's left and right RFs. Here we set to resolve this issue by studying the dependence of cells' disparity tuning on their underlying RF structures through mathematical analyses and computer simulations. We model the disparity tuning curves in Wagner and Frost's experiments and demonstrate that the mere existence of approximate CDs in real cells cannot be used to distinguish the phase-parameter-based RF description from the traditional position-shift-based RF description. Specifically, we found that model simple cells with either type RF description do not have a CD. Model complex cells with the position-shift-based RF description have a precise CD, and those with the phase-parameter-based RF description have an approximate CD. We also suggest methods for correctly distinguishing the two types of RF descriptions. A hybrid of the two RF models may be required to fit the behavior of some real cells, and we show how to determine the relative contributions of the two RF models.

Animals↗