Biomedical subjects

N Quigley

Publications and source records attributed to N Quigley.

6 recordsLinked to original sources

PubMed1994

A case report of severe external resorption.

External root resorption is a multifactorial process with many causes. Except for transient surface resorption, it is usually considered an irreversible process. Treatment can arrest or retard the resorptive process. Many factors that have been associated with this process include physiologic resorption, local factors, systemic conditions, and idiopathic resorption. This case report documents a 29-year-old white male who suffered a motor vehicle accident and dental trauma nine years ago. The accident resulted in the lateral displacement of the maxillary right canine. The maxillary right lateral incisor, right central incisor and left central incisors were avulsed. The right central incisor was never recovered from the accident site. The other teeth were replanted 90 minutes after the accident and rigidly splinted for six months. They then received root canal treatment, approximately one month after the splint was removed (seven months from time of the trauma). On annual examination, the patient complained of a loose maxillary fixed prosthesis. He was diagnosed with severe external resorption on the right lateral and left central incisors, and severe external replacement resorption on the right canine. This case report reviews the current trends in the treatment of avulsed teeth and the resorptive process.

Adult↗

PubMed1994

Changes in the pattern of deliberate self-poisoning presenting at Craigavon Area Hospital: 1976, 1986 and 1991.

Deliberate self-poisoning presenting at Craigavon Area Hospital in 1991 was examined and compared to the years 1976 and 1986. Self-poisoning has not declined over the 15 year period 1976-1991. The reduction in the use of benzodiazepines, and increase in paracetamol, previously reported, continues. Possible reasons for this are examined, in relation to local and national drug prescribing.

Acetaminophen↗

PubMed1993

A multiphase system bone implant for regenerating the calvaria.

The regeneration of bone with a biodegradable, biocompatible carrier and osteo-regenerative proteins may be possible if the carrier has the appropriate architecture to support osteoconduction and prevent soft-tissue prolapse into ablated bone segments. Using radiomorphometry and histomorphometry, our group assessed individually and combined the components of a multiphase system bone implant (MSI) in rabbit cranial defects (critical-size defects: CSDs): two disks of biodegradable polymer (PLG) and demineralized bone matrix (DBM), a recognized osteo-regenerative material. We used 48 rabbits evenly divided between four treatment groups and two time periods. Six weeks after treatment, both DBM and PLG had significant positive effects on bone regeneration (based on a three-factor analysis of variance, p < 0.05). These effects were synergistic when the components were combined (MSI). Defects treated with DBM or PLG alone continued to regenerate bone through 12 weeks. By this time, bone within the defects treated with MSI appeared to be maturing and consolidating. We conclude that the concept of placing osteo-regenerative factors between two biodegradable disks for regenerating segments of calvaria is viable.

Animals↗

PubMed1991

Cranial, iliac, and demineralized freeze-dried bone grafts of the mandible in dogs.

Both autogenous bone grafts and demineralized freeze-dried allogeneic bone implants were evaluated for mandibular reconstruction. Four-centimeter segmental defects of the midbody of the edentulous mandible were reconstructed in 36 dogs, with specimens recovered at 3 and 6 months and quantitatively compared for total and new bone by histomorphometric analysis. Autogenous grafts consisted of corticocancellous cranial block (CB), corticocancellous iliac block (IB), and particulate cancellous iliac marrow (PM). The allogeneic bone was demineralized and freeze-dried, and consisted of particulate cortical endochondral bone (FP), cranial cortical block (FCB), and iliac cortical block (FIB). Clinically and histomorphometrically, results appeared to indicate that (1) CB compared favorably with IB at 3 and 6 months for total bone, but IB showed a trend for more new bone formation at 6 months, a trend that may be due to the thicker cortical component of CB, which requires longer time periods to remodel than the cancellous rich IB; (2) FP failed to achieve bony union at 3 months, with inadequate rates of new bone formation; and (3) FCB and FIB compared favorably for total bone with CB and IB at 6 months, although new bone for autogenous CB and IB was 26.9% and 45.4%, while new bone for allogeneic FCB and FIB represented only 7.9% and 17.4%.

Animals↗

PubMed1991

A comparison of four particulate bone derivatives.

Samples of four types of particulate bone matrix derivatives were prepared and surgically inserted into standardized critical-sized defects in calvariae of Long-Evans rats. Implantation of demineralized bone matrix (DBM), bone regenerative matrix, and two types of particulate chemosterilized, antigen-extracted, autolyzed, allogeneic (AAA) bone from endochondral (eAAA) and intramembranous (iAAA) sources will result in the regeneration of bone in orthotopic skull defects. The four preparations were tested in orthotopic, 8-mm calvarial wounds to compare the quantity of new bone that formed 28 days postimplantation. Quantitative computer imaging was used to measure roentgenographic gray levels and bone volume of new trabeculae (calcified plus osteoid). All experimental bone matrix derivatives produced more bone volume than the nontreated control wounds. Bone volume regenerated from iAAA was significantly less than eAAA and DBM-regenerated bone.

Analysis of Variance↗

PubMedDate not supplied

Odontogenic keratocyst.

Odontogenic keratocysts comprise approximately eight percent of all jaw cysts and have a significant recurrence rate. Following a review of the literature, the treatment of two patients with such cysts is described.

Adolescent↗