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Biomedical subjects

N R Armstrong

Publications and source records attributed to N R Armstrong.

6 recordsLinked to original sources
PubMed2001

Light-emitting electrochemical processes.

Electrochemical processes leading to light emission are reviewed, with emphasis on aspects of this subject relevant to the understanding and optimization of electrogenerated luminescence (EL) in organic thin-film materials. The basic energetic requirements of light emission from electrochemically initiated solution redox reactions [electrogenerated chemiluminescence (ECL)] are reviewed first. This review is followed by a discussion of light-emitting electrochemical processes that have been observed in hybrids of ionically conducting polymers and electronically conducting polymers. Finally, the features of EL in insulating polymers and molecular thin films are reviewed, along with recent electrochemical and ECL studies of the small-molecule components of certain organic light-emitting diodes. These studies provide a conceptual framework for understanding and optimizing these materials and the EL process.

Journal Article↗
PubMed2000

Preparation of polyetherol-appended sulfur porphyrazines and investigations of peripheral metal ion binding in polar solvents.

We describe the complete synthesis and characterization of a new family of peripherally functionalized porphyrazines (pz's) with four, three, or two (in a trans conformation) bis[thioethoxy(ethoxy)ethanol] moieties appended at the pyrroles. These "polyetherol" groups serve as weak exocyclic binding sites for a number of metal ions and also provide solubility of the pz's in low molecular-weight alcohols and water. Electronic spectra of the modified porphyrazines exhibit distinct changes in the visible region (both absorbance and fluorescence) in response to treatment with Ag+, Pb2+, Cd2+, Cs+, and Ni2+ in solution. Such properties make these compounds intriguing candidates for incorporation into the transducer layers in optically based chemical sensors.

Ethers↗
PubMed1994

Fabrication and characterization of low-loss, sol-gel planar waveguides.

Applications of planar integrated optical waveguide (IOW) technology to problems in surface spectroscopy and optical chemical sensing have been partly limited by the difficulty of producing high-quality glass IOWs. The fabrication of IOWs by the sol-gel method from methyltriethoxysilane and titanium tetrabutoxide precursors is described here. The physical, chemical, and optical properties of the films during and after high-temperature annealing were studied using a variety of analytical techniques. The results show that the catalyst used to accelerate the sol-gel reaction strongly influenced the optical quality of the IOW. HCl catalysis produced waveguides with propagation losses of approximately 1 dB/cm, whereas in the case of SiCl4 catalysis, propagation losses were < 0.2 dB/cm, a value significantly less than any previously reported for sol-gel-derived IOWs. An examination of film surface structure and morphology by scanning electron microscopy and atomic force microscopy showed that the SiCl4-catalyzed IOWs were significantly smoother and more homogeneous on a submicrometer scale than the HCl-catalyzed IOWs. The use of SiCl4 is thought to retard formation of a microheterogeneous network containing Si-rich and Ti-rich domains, which is favored with HCl catalysis and contributes to the higher observed losses.

Fiber Optic Technology↗
PubMed1987

Electroconvulsive shock but not antidepressant drugs increases alpha 1-adrenoceptor binding sites in rat brain.

Treatment of rats with electroconvulsive shock once daily for 10-12 days increased the density of alpha 1-adrenoceptors labeled by [3H]prazosin in homogenates of frontal cerebral cortex. A single treatment did not affect [3H]prazosin binding. Repeated treatment with electroconvulsive shock did not appear to affect alpha 1-adrenoceptor binding in the hippocampus or hypothalamus. Treatment of rats with reserpine also increased [3H]prazosin binding in the frontal cortex. In contrast to electroconvulsive shock, three weeks administration of tricyclic antidepressant drugs, monoamine oxidase inhibitors, or atypical antidepressant drugs did not significantly affect [3H]prazosin binding sites in the frontal cortex. The affinities of antidepressant drugs for alpha 1-adrenoceptors ranged from about 50 nM for tricyclic and atypical antidepressants to about 100 microM for monoamine oxidase inhibitors. The high affinities of the tricyclic and atypical antidepressant drugs for alpha 1-adrenoceptors could contribute to clinical differences between these classes of drugs and monoamine oxidase inhibitors. Furthermore, the electroconvulsive shock-induced increase in alpha 1-adrenoceptors could contribute to differences in clinical effects between this treatment and antidepressant drugs.

Animals↗