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Biomedical subjects

N R Baker

Publications and source records attributed to N R Baker.

42 records · Page 3Linked to original sources
PubMedDate not supplied

Heterogeneity and reduction in pulmonary clearance of mucoid Pseudomonas aeruginosa.

Mucoid, alginate-producing Pseudomonas aeruginosa isolated from patients with cystic fibrosis were studied to determine the extent of heterogeneity of the isolates within individual sputa. Considerable heterogeneity involving cultural requirements for mucoid colonial growth was observed, and sensitivity to the beta-lactam antibiotic carbenicillin was also variable. For determining if the presence of alginate increased pulmonary survival of the bacteria, groups of rats were infected by transtracheal instillations of equivalent numbers of mucoid or nonmucoid P. aeruginosa, and survival was measured as the percentage of inoculum colony-forming units cultured from lung homogenates. Increased pulmonary survival of mucoid P. aeruginosa was observed in animals killed 3 hr or 6 hr after infection with unwashed bacteria. No difference in survival between mucoid and nonmucoid cells was observed when bacteria were washed prior to instillation. It was concluded that a single mucoid colony isolated from a sputum does not fully represent the population of mucoid P. aeruginosa within the patient and that pulmonary killing of mucoid P. aeruginosa can be less efficient than that for nonmucoid strains.

Animals↗
PubMedDate not supplied

Sustained silver-releasing dressing in the treatment of diabetic foot ulcers.

This study investigated the clinical performance and safety of a sustained silver-releasing foam dressing, Contreet Foam, in the treatment of diabetic foot ulcers. Twenty-seven patients with diabetic foot ulcers of grade I or II (Wagner's classification) were followed for six weeks: one week run-in using Biatain dressings, four weeks' treatment with Contreet dressings. Four ulcers healed during the four-week treatment with Contreet 56% in average. Contreet Foam showed good exudate management properties and was considered easy to use. Only two infections occurred showed that all six of the non-study ulcers developed an infection during the study. All ulcers (study ulcers as well as non-study ulcers) were treated according to good practice of diabetic wound care. There were no directions for the treatment of secondary wounds. No device-related adverse events were observed. This study demonstrated that Contreet Foam is safe and easy to use and effectively supports healing and good wound progress of diabetic foot ulcers.

Adult↗