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N R Elaev

Publications and source records attributed to N R Elaev.

31 records · Page 2Linked to original sources
PubMedDate not supplied

[Glycosaminoglycans in syrinogomyelia].

Excretion of glycosaminoglycans (GAG) with urine was 2.7-fold decreased in patients with syringomyelia as compared with healthy persons. Patterns of GAG decreased excretion are genetically determined and inherited as dominant features. Content of GAG was decreased in the patients skin, cerebrospinal fluid and brain by 30%, 40% and 20-40%, respectively; content of GAG was increased by 80% in spinal cord where the pathological process was localized. The data obtained suggest that considerable impairment of connective tissue metabolism occurred in syringomyelia.

Brain Chemistry↗
PubMedDate not supplied

[Noradrenaline as a RNA and Na K ATPase biosynthesis regulator in the neurons].

Noradrenaline (10(-5)M) inhibits the summary RNA synthesis in isolated neurone nuclei. In the presence of the dissolvable cytoplasmic fraction noradrenaline effect is transformed: 3H-UTP inclusion into RNA is activated. Similar results were seen in experiments with adenosine-3',5'-cyclophosphate and previously with acetylcholine. The data obtained indicate the presence of the neurone cytoplasmic factor (factors) interacting with biogenic amines and cyclic nucleotides and influencing RNA synthesis in such a complex. In the cell-free system noradrenaline inhibits Na, K-ATPase synthesis, its effect being directed at RNA synthesis inhibition upon DNA gene of Na, K-ATPase. These findings allow a conclusion that a part of neurone genes undergo noradrenaline control: the expression of several ones is activated and of the other is inhibited--the former being higher than the latter, according to noradrenaline effect on the summary RNA synthesis. Noradrenaline does not influence the glial cell RNA and DNA syntheses.

Animals↗
PubMedDate not supplied

[Intracellular hormonal function of acetylcholine and noradrenaline: the regulation of the catalase level in liver cells].

The injection of acetylcholine (15 to 150 micrograms/100 g) to rats or preincubation in the hepatic homogenate with acetylcholine (10(-6) to 10(-3) M) induces a decrease in the catalase activity, mainly in its bound form. Acetylcholine effect does not manifest in the presence of actinomycine D and puromycine. Noradrenaline injection to animals (1.5 to 15 micrograms/100 g) or preincubation of the hepatic homogenate with noradrenaline (10(-6) to 10(-3) M) produces a rise of the catalase activity (mainly of its bound form), being blocked by actinomycine D and non-blocked by propranolol. Acetylcholine- and noradrenaline action on the catalase level is not mediated by cyclic nucleotides and may be considered as intracellular hormonal effect.

Acetylcholine↗