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Biomedical subjects

N R Ghatak

Publications and source records attributed to N R Ghatak.

At least 55 records · Page 3Linked to original sources
PubMed1978

Multiple vascular malformation in the "blue rubber bleb naevus" syndrome: a case with aneurysm of vein of Galen and vascular lesions suggesting a link to the Weber-Osler-Rendu syndrome.

A case of Bean's syndrome is reported in which a wide variety of vascular malformations are illustrated. Among these were multiple arterio-venous malformations including a so-called vein of Galen aneurysm. A comparison of this case with those in the literature suggests that the pathology in patients with Bean's syndrome may be more varied than heretofore recognized, and that an overlap between this syndrome and the Osler-Weber-Rendu syndrome may exist.

Adult↗
PubMed1978

Association of central pontine myelinolysis and Marchiafave-Bignami disease.

Combined pathologic features of central pontine myelinolysis and Marchiafava-Bignami disease occurred in a 53-year-old man with chronic alcoholism. This association is rare despite the basic similarities of these two disorders. The combination of both conditions in the same patient suggests a common pathogenetic mechanism.

Alcoholism↗
PubMed1978

Myelopathy presenting as an intrinsic spinal cord tumor.

Two patients are presented who became progressively quadriplegic with myelographic appearances suggesting intrinsic spinal cord tumors. In both cases, laminectomy and biopsy of the spinal cord disclosed non-neoplastic conditions (neuromyelitis optica and acute necrotic myelopathy) confirmed at autopsy. Since surgery is not helpful in such cases, the problems of differentiation between such lesions and intraspinal tumors are reviewed.

Adolescent↗
PubMed1977

Further observation on the fine structure of a colloid cyst of the third ventricle.

The fine structure of a surgically excised colloid cyst is described. The cyst was lined by ciliated and nonciliated columnar cells. The nonciliated cells contained secretory material and had a surface coating. In addition, a third type of smaller cell was seen wedged between the columnar cells and abutting on the basement membrane. These cells contained abundant free ribosomes and tonofilaments and displayed well developed desmosomes and half desmosomes. The cyst lining closely resembled the upper respiratory epithelium rather than neuroepithelium, thus supporting the contention that colloid cysts are derived from an endodermal source.

Adult↗
PubMed1977

Fine structure of the cerebellar cortex in Menkes Kinky-hair disease. X-chromosome-linked copper malabsorption.

The cerebellar cortices in two patients with X-chromosome-linked copper malabsorption (Menkes kinky-hair disease) were examined with both the light and electron microscope. Somatic sprouts and grotesque dendritic arborization were among the obvious light microscopical changes. At the fine structural level, the Purkinje cells were characterized by the presence of somatic spines although the surviving granule cells had already descended. Most spines were parts of synaptic complexes, but some were unattached to any presynaptic element. Similar spines were also observed on dendritic trunks. Astrocytic gliosis and nonspecific endothelial cell changes were noted.

Axons↗
PubMed1977

Neuropathology of tissues from patients treated by the Brain Tumor Study Group.

The histopathologic diagnoses in 718 brain tumor patients entered in the Brain Tumor Study Group were reviewed, as well as those for 53 of these patients who were reviewed, as well as those for 53 of these patients who were autopsied later. This review documented instances of progression of histologic analplasia. Of particular interest in the autopsied cases were several instances of extensive necrosis in white matter distant from persisting glioma following chemotherapy and radiotherapy. This observation suggested the presence of a structural and/or metabolic alteration in the diseased hemisphere that perhaps makes it more susceptible to further alterations secondary to the adjunctive therapy.

Adult↗
PubMed1976

Extensive calcification in a tumor of the glomus jugulare.

Extensive calcification in the intracranial portion of a glomus jugulare tumor is reported. This finding has not been reported previously in the literature. The patient probably was afflicted with this process for many years and presented with a subarachnoid hemorrhage. The combination of this tumor with subarachnoid hemorrhage is rare.

Calcinosis↗
PubMed1976

Unusual intravascular material in the brain. Autopsy findings in a patient treated with antihemophilic factor concentrates.

Widespread vascular occlusion caused by unusual particulate material in the brain of a patient who was intensively treated with antihemophilic factor (AHF) concentrates prior to death is described. The intravascular particles were seen partially or completely occluding both veins and arteries of small caliber in the brain and also to a much lesser extent in other organs. The resultant small focal infarcts were predominantly distributed in the cerebral white matter. The pathogenesis of this apparently unique vascular occlusive phenomenon and its relationship, if any, to the massive AHF concentrate infusion in this patient remain unknown.

Autopsy↗
PubMed1976

Cerebellar degeneration following long-term phenytoin therapy.

Diffuse loss of cerebellar Purkinje cells and to some extent, of granule cells occurred in a 78-year-old woman who had been continually treated with phenytoin for more than 20 years and in whom progressive cerebellar deficits developed in the later years of life. In the absence of other demonstrable cause, the selective morphologic changes in the cerebellum are attributed to long-term administration of phenytoin.

Aged↗
PubMed1976

Ultrastructural evidence for CSF production by a choroid plexus papilloma.

A choroid plexus papilloma (CPP) removed from a child with communicating hydrocephalus was studied with the electron microscope. In addition to the usual organelles, the neoplastic epithelial cells contained polypoid microvilli, cilia, coated pinocytotic vesicles, and apical tight junctions. The basal surfaces were consistently juxtaposed to large capillaries lined by fenestrated endothelium. The fine structural details of the tumor were essentially the same as those of normal CP and thus appeared ideally suited for an active secretory function. Two additional features in this tumor were tubular bodies in the endothelium and well developed pericytes. The present findings provide strong evidence for cerebrospinal fluid production by CPP, a phenomenon that has long been suggested by clinical observation.

Brain Neoplasms↗
PubMed1976

Extracranial meningioma presenting as lytic skull lesion.

A meningioma that had replaced the outer table of the skull and thinned the inner table but had no intracranial extension appeared as a solitary lytic lesion on routine roentgenograms of the skull. It was removed without complications.

Adult↗
PubMed1975

Unusual infections of the nervous system in malignant lymphomas.

Infection of the nervous system by toxoplasma, cytomegalovirus and varicella-zoster virus is described in three adult patients with malignant lymphoma. Morphologic identification of these organisms in otherwise nonspecific lesions is emphasized. Since such intercurrent infections are not usually diagnosed clinically in debiliated patients, their recognition at autopsy is important, particularly in view of the wide spread distribution of these organisms in normal population.

Aged↗
PubMed1975

Unususpected meningioma in a patient with pituitary gigantism. Case report with autopsy findings.

A unique example of a clinically unsuspected large parasellar meningioma is described in a 36-yr-old pituitary giant who had been treated initially with conventional irradiation, subsequently by surgical excision of an acidophil adenoma, and ultimately with medroxyprogesterone acetate (MPA) prior to his demise. The patient died of increased intracranial pressure resulting from a combined mass effect of the meningioma and recurrent tumor. The relationship between radiation and the development of the meningioma is discussed, as well as the fine ultrastructure of a highly functioning acidophil adenoma.

Adult↗
PubMed1975

Pathology of cerebral embolization caused by nonthrombotic agents.

Although apparently infrequent, a variety of agents other than thrombotic material are known to cause cerebral embolization, often with serious consequences. The emboli may originate in different parts of the body or may be introduced from outside under diverse circumstances. The pathologic aspects of these individual embolic phenomena are described with particular emphasis on their recognition at autopsy. Adequate autopsy study appears to be the most important source of information for further elucidation of the incidence, mechanism, and sequelae of these heterogeneous embolic lesions of the brain. Such information is essential for clinical evaluation, management, and, more importantly, prevention of some of these potentially serious embolic phenomena.

Arteriosclerosis↗
PubMed1975

Intracerebral schwannoma.

A case is reported in which the authors describe a rare example of an intracerebral schwannoma in a 63-year-old woman having a clinical history suggesting the presence of the tumor for 40 years. Such an unusually prolonged course is ascribed to extensive regressive changes in the tumor. The occurrence of intracerebral schwannoma indicates the existence of schwann cells deep within the brain substance, although the precise source of these cells remains obscure.

Brain Neoplasms↗