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Biomedical subjects

N Rabinovici

Publications and source records attributed to N Rabinovici.

11 recordsLinked to original sources
PubMed1980

Structural changes in the perfused canine kidney exposed to the direct action of endotoxin.

We attempted to clarify whether structural damage or hemodynamic alterations is the primary cause of renal failure in the initial phases of endotoxic shock. Endotoxin (0.5 mg/kg) was infused directly into the renal artery and normal renal hemodynamics were maintained by cross-perfusion and controlled pressure. Direct exposure of renal parenchyma to endotoxin action was followed by changes in structure at the cellular and subcellular levels. The damage was unequally distributed and involved mainly the mitochondria and lysosomes of the distal and proximal convoluted tubules. No significant structural changes could be detected in the glomeruli or in the vascular compartment. There was no direct relationship between the degree of mitochondrial and lysosomal damage and the changes in enzymatic activity. The enzymatic systems associated with active Na transport and glycogen breakdown showed only slight alterations, while those related to energy production, hydrogen transfer and the respiratory activity of the cell were severely affected. These results indicate that structural damage in the nephron may contribute to the renal failure in the initial phase of endotoxemia.

Acid Phosphatase↗
PubMed1980

The relationship between respiration, pressure and flow distribution in the vena cava and portal and hepatic veins.

Factors affecting blood movement in the main vessels of the venous system and the changes in pressure and flow values in the vena cava and portal and hepatic veins were simultaneously recorded and related to the phases of the respiratory cycle. The experiments were done in rabbits subjected to nembutal anesthesia, with open abdomen, closed chest and spontaneous respiration. The results indicate an asymmetric pressure gradient in the vena cava centered around the diaphragm with larger pressure differences in the thoracic segment; no pressure gradient in the portal vein, and a sharp gradient of possible functional significance at the caval end of the hepatic veins. Portal, hepatic and abdominal caval pressures were positive, but above the diaphragm, vena cava pressure values were predominantly negative. Flow was continuous, unequally distributed throughout the components and fluctuating alternatively during one respiratory cycle. Maximal pressure and flow values in the portal and hepatic veins were concomitant with the lowest values in the vena cava and closely related to respiration. The distribution of opposite pressure and flow values within the components and their integration during one respiratory cycle suggest that, in the process of venous return, each component and each segment fulfills simultaneously different functions co-ordinated by respiration and cardiac activity.

Animals↗
PubMed1977

The effect of furosemide on the flow and composition of bile in the dog.

The effect of furosemide, a potent inhibitor of active sodium transport, on the amount and composition of bile was studied in the dog. Ten milligrams per kilogram of body weight of furosemide were injected intravenously to anesthetized dogs with a previously constructed fistula of the common bile duct. In all dogs, a 2.5 times increase in bile flow was observed concomitant with a 15 times increase in urinary output. The amount of bile flow decreased gradually and returned to control levels 60 to 75 minutes after furosemide injection. The choleretic effect was associated with a high increase in sodium, chloride and bicarbonate anions and with a smaller increase in potassium, phosphorus and calcium. The total amount of bilirubin alkaline phosphatase and cholesterol was not significantly affected, while the calculated output of inorganic salts increased. The results indicate that inhibition of sodium reabsorption by furosemide simultaneously affects the liver and kidney and that the increase in electrolyte solution is most likely caused by the inhibition of sodium reabsorption in the ductuli. Furosemide also may interfere with the sodium mediated secretory fraction at the canalicular level, but the predominant factor determining the increase in bile flow and electrolytes is inhibition of sodium reabsorption in the biliary ducts and ductuli.

Alkaline Phosphatase↗
PubMed1976

Gallstone pancreatitis. Exploration of the biliary system in acute and recurrent pancreatitis.

During a five-year period, 82 patients were treated for acute pancreatitis, 63 of whom were proved to have associated biliary tract disease. In 18 of the 63, the accepted preoperative diagnostic measures failed to demonstrate pathologic findings in the biliary system. In 16 of the 18 patients, stones were discovered at the time of operation, although in five they were so small as to be demonstrable only filtering the aspirated bile through gauze. In the two of the 18 without stones, cholecystitis was present. In 14 patients the ducts choledochus and the pancreatic duct had a common path. All patients had no further pancreatitis two to eight years cholecystectomy. In Israel, where alcoholism is rare, three fourths of the cases of acute pancreatitis are associated with gallbladder disease.

Acute Disease↗
PubMedDate not supplied

Leiomyosarcoma of the rectum: diagnostic criteria and surgical approach.

A case of leiomyosarcoma of the rectum is reported. There was difficulty in establishing the correct histologic diagnosis. Diagnostic criteria, including electron microscopy examination, are reviewed. Abdominoperineal resection of the rectosigmoid is the common therapeutic procedure recommended.

Aged↗