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N Raknerud

Publications and source records attributed to N Raknerud.

49 records · Page 3Linked to original sources
PubMed1983

TSH unresponsiveness, a case report.

A patient with congenital primary hypothyroidism is presented. His thyroid gland had a normal uptake of radioiodine which was independent of endogenous or exogenous TSH, sympathetic B-receptor blockade or prostaglandin inhibition. Infusion of dibuturyl-cyclic AMP increased the uptake of radioiodine and stimulated release of protein bound 131I. He had no goitre even when he did not receive thyroxine, but thyroid histology showed evidence of active epithelium in the presence of adequate substitution with thyroxine. We assume that some unknown factor other than TSH stimulates part of the glandular function in this patient, without leading to adequate formation and release of thyroid hormone.

Aged↗
PubMed1982

Treatment of mercuric chloride poisoning with dimercaptosuccinic acid and diuretics: preliminary studies.

The distribution and excretion of mercury were studied in mice given a single injection of HgCl2 with or without chelation treatment. DMS (2,3-dimercaptosuccinic acid) given intravenously (0.5 mmol SH/kg) to mice 24 h after the mercury injection reduced the kidney Hg level significantly, while NAPA (N-acetyl-DL-penicillamine) and BAL (2,3-dimercaptopropanol) did not. The effectivity of DMS to remove Hg from kidneys was comparable to that of BAL-sulph (2,3-dimercaptopropane-1-sulfonate), irrespective of whether these chelating agents were given orally or intravenously. Immediate chelation treatment with DMS or mercaptodextran reduced the renal Hg level to about 50% of control levels, as measured 3 d after the treatment. Combination of DMS with immediate intraperitoneal treatment with spironolactone was even more effective in reducing the renal levels, and acted both by increasing the fecal and urinary excretion. The DMS treatment, as well as DMS + spironolactone in combination, could protect against kidney damage following injection of 30 mumol HgCl2/kg. Such treatment was essentially nontoxic.

Animals↗
PubMed1977

The ultrastructure of the interfollicular epidermis of the hairless (hr/hr) mouse. V. The cytoplasm of the horny cells.

The ultrastructure of horny cells in the interfollicular epidermis of the hairless mouse and in the mouse with hair has been studied with particular emphasis on changes in the cytoplasm through the horny layer. Horny cells from the two strains have a similar appearance, and the horny layer can be divided into three sublayers, each with a different ultrastructure. It is suggested that in vivo the same arrangement of densely packed filaments and fibrils which represents the keratin pattern in the basal sublayer is preserved throughout the horny layer. However, the filaments and interfilamentous substance seem to undergo a continuous transformation, which possibly results in a disintegration of the filaments when desquamation of the uppermost cell takes place.

Animals↗
PubMed1976

The ultrastructure of the interfollicular epidermis of the hairless (hr/hr) mouse. IV. Lamellated bodies (Odland bodies, membrane-coating granules) and intercellular material in the upper part of the granular and horny layers.

The appearance of the lamellated bodies (Odland bodies, membrane-coating granules, keratinosomes) and intercellular material in the upper part of the granular and horny layers of the interfollicular epidermis of the hairless mouse was studied. In order to obtain more information about these structures various fixation procedures were used. The bodies displayed a lamellated pattern after osmication and uneven staining of the lamellae was seen after osmium zinc iodide fixation. Glutaraldehyde fixation made the bodies appear electron-empty except for some electron-dense material mainly at their periphery. These observations indicate that the bodies are mainly composed of lipids. The bodies were discharged to the intercellular space in tthe upper part of the granular layer where they disintegrated. The appearance of the intercellular space in the horny layer varied considerably with the fixation procedure indicating that artefacts were produced during the processing of the specimens. Based on the observations after various fixation methods it is suggested that the intercellular space in vivo is completely filled with a substance which stained weakly osmiophilic. In this substance very osmiophilic structures of various shapes and sizes may be present.

Animals↗